[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100629039":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":30,"centralContacts":34,"locations":43,"responsibleParty":62,"collaborators":65,"id":69,"slug":25,"hasResults":70,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":25,"eligibilityCriteria":74,"healthyVolunteers":75,"sex":76,"minAge":77,"maxAge":78,"enrollmentInfo":79,"targetDuration":25,"studyType":82,"phases":83,"briefSummary":85,"conditions":86,"keywords":90,"overallStatus":46,"whyStopped":25,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":104},{"fullName":5,"class":6},"University of Reading","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Pyridoxal-5'-Phosphate supplement","EXPERIMENTAL","100mg Vitamin B6 as pyridoxal-5-phosphate, daily with food",[13],"Drug: Pyridoxal-5'-Phosphate supplement",{"label":15,"type":16,"description":17,"interventionNames":18},"Microcrystalline Cellulose Placebo","PLACEBO_COMPARATOR","Placebo capsule, daily with food",[19],"Drug: Placebo Supplementation",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","100mg PLP in the form of a tablet, taken once a day for 1 week",[9],null,{"type":22,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Placebo Supplementation","Placebo supplement in the form of a capsule.",[15],[31],{"name":32,"affiliation":5,"role":33},"David T Field","PRINCIPAL_INVESTIGATOR",[35,40],{"name":36,"role":37,"phone":38,"phoneExt":25,"email":39},"Alex Cameron","CONTACT","0118 378 6803","a.cameron@pgr.reading.ac.uk",{"name":32,"role":37,"phone":41,"phoneExt":25,"email":42},"+44 1183785004","d.t.field@reading.ac.uk",[44],{"facility":45,"status":46,"city":47,"state":48,"zip":49,"country":50,"countryCode":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":58},"Harry Pitt Building","RECRUITING","Reading","England","RG6 6ES","United Kingdom","UK",{"type":53,"coordinates":54},"Point",[55,56],-0.97113,51.45625,{"lat":56,"lon":55},[59],{"name":60,"role":37,"phone":61,"phoneExt":25,"email":39},"Alexander Cameron","07710555979",{"type":33,"investigatorFullName":63,"investigatorTitle":64,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"David Field","Associate professor",[66],{"name":67,"class":68},"eBeauty Ltd Innopure, Regus House, Cardiff Gate Business Park, Malthouse Avenue, Cardiff, CF23 8RU","UNKNOWN","100629039",false,"NCT07469462","The Effects of High-dose Vitamin B6 on Depression and Anxiety Symptoms","An EEG Study to Investigate the Effect of High-dose Vitamin B6 Supplementation on Neural Activity in Relation to Depression and Anxiety Symptoms.","Inclusion Criteria:\n\n* Over 18 years of age and under 41\n* Mild to moderate anxiety and\u002For depression\n* Normal or corrected to normal vision\n\nExclusion Criteria:\n\n* not taking daily dietary supplement containing \\>2 mg Vitamin B6\n* not taking medication that is a GABA agaonist (our team will check this with you)\n* not be pregnant\n* no medical history of epilepsy\n* no medical history of peripheral neuropathy\n* not taking the antibiotic Seromycin (prescribed for tuberclosis or urinary tract infection)\n* no history of brain injury or recent concussion",true,"ALL","18 Years","41 Years",{"count":80,"type":81},44,"ESTIMATED","INTERVENTIONAL",[84],"NA","This clinical trial investigates the effects of Vitamin B6 supplementation on neural inhibition using electroencephalography (EEG), in relation to depression and anxiety symptoms in participants from the general population with a relatively high level of symptoms at baseline. Researchers will compare a placebo group to high-dose Vitamin B6 to test the hypothesis that Vitamin B6 moves the excitation\u002Finhibition balance towards inhibition.",[87,88,89],"Neural Inhibition","Anxiety","Depression",[91,92,93,94,89,88],"Vitamin B6","Excitation-Inhibition Balance","GABA","Electroencephalograpgy","2026-04-27",{"date":97,"type":98},"2026-04-28","ACTUAL",{"date":100,"type":81},"2026-05-01",{"date":102,"type":81},"2026-11",{"name":5,"class":6},1]