[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100560021":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":30,"centralContacts":37,"locations":43,"responsibleParty":70,"collaborators":30,"id":72,"slug":30,"hasResults":73,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":30,"eligibilityCriteria":77,"healthyVolunteers":78,"sex":79,"minAge":80,"maxAge":30,"enrollmentInfo":81,"targetDuration":30,"studyType":84,"phases":85,"briefSummary":87,"conditions":88,"keywords":94,"overallStatus":46,"whyStopped":30,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":107},{"fullName":5,"class":6},"Integrative Skin Science and Research","INDUSTRY",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Almond Oil","EXPERIMENTAL","Almond Oil. 1-2 Drops of randomized topical product will be applied on entire face nightly. Duration: 16 weeks",[13],"Other: Topical Product: Almond Oil",{"label":15,"type":10,"description":16,"interventionNames":17},"Almond oil augmented with 0.5% Vitamin E","Almond oil augmented with 0.5% Vitamin E. 1-2 Drops of randomized topical product will be applied on entire face nightly. Duration: 16 weeks",[18],"Other: Topical Product: Almond oil augmented with 0.5% Vitamin E",{"label":20,"type":10,"description":21,"interventionNames":22},"0.025% Tretinoin oil augmented with castor oil","0.025% Tretinoin oil augmented with castor oil. 1-2 Drops of randomized topical product will be applied on entire face nightly. Duration: 16 weeks",[23],"Other: Topical Product: 0.025% Tretinoin oil augmented with castor oil",[25,31,34],{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"OTHER","Topical Product: Almond Oil","1-2 Drops of randomized topical product will be applied on entire face nightly.",[9],null,{"type":26,"name":32,"description":28,"armGroupLabels":33,"otherNames":30},"Topical Product: Almond oil augmented with 0.5% Vitamin E",[15],{"type":26,"name":35,"description":28,"armGroupLabels":36,"otherNames":30},"Topical Product: 0.025% Tretinoin oil augmented with castor oil",[20],[38],{"name":39,"role":40,"phone":41,"phoneExt":30,"email":42},"Nasima Afzal","CONTACT","915-750-2463","nasima@integrativeskinresearch.com",[44],{"facility":45,"status":46,"city":47,"state":48,"zip":49,"country":50,"countryCode":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":58},"Integrative Research Institute","RECRUITING","Sacramento","California","95819","United States","US",{"type":53,"coordinates":54},"Point",[55,56],-121.4944,38.58157,{"lat":56,"lon":55},[59,60,64,67],{"name":39,"role":40,"phone":41,"phoneExt":30,"email":42},{"name":61,"role":40,"phone":62,"phoneExt":30,"email":63},"Sarah Adnan","9157502463","sarah@integrativeskinresearch.com",{"name":65,"role":66,"phone":30,"phoneExt":30,"email":30},"Raja Sivamani, MD","PRINCIPAL_INVESTIGATOR",{"name":68,"role":69,"phone":30,"phoneExt":30,"email":30},"Rubaina Dang, ND","SUB_INVESTIGATOR",{"type":71,"investigatorFullName":30,"investigatorTitle":30,"investigatorAffiliation":30,"oldNameTitle":30,"oldOrganization":30},"SPONSOR","100560021",false,"NCT06571721","The Effects of Topical Almond Oil and Tretinoin on Facial Wrinkles","Prospective, Double-Blinded, Randomized Study of Topical Almond Oil and Tretinoin on Facial Wrinkles","Inclusion Criteria:\n\n* Post-menopausal women of Fitzpatrick skin types 1, 2, and 3\n* Individuals with facial fine lines and wrinkles\n\nExclusion Criteria:\n\n* Individuals who are pregnant or breastfeeding\n* Prisoners\n* Adults unable to consent\n* Those with a nut allergy or tocopherol allergy\n* Current smokers, those that have smoked within the past year, and former smokers with greater than a 10-pack- year history of smoking\n* Those with an autoimmune photosensitive condition or a known genetic condition with a deficiency in collagen production (such as Ehlers-Danlos syndromes)\n* Those who have undergone any cosmetic procedures to the face in the 3 months prior to enrollment in the opinion of the investigator. People that have undergone deeper chemical peels (TCA based peels) within 1 year prior to enrollment\n* Individuals who are unwilling to discontinue vitamin E containing supplements and food sources such as all nuts, sunflower seeds or sunflower oil during the washout and intervention\n* Individual who are unwilling to discontinue topical cosmetic products during the duration of the study or unwilling to undergo a 2-week washout of topicals that are known to modulate collagen and pigment:\n* Retinoids such as tretinoin, adapalene, retinol, except as provided by the study.\n* Antioxidant ingredients such as vitamin C or vitamin E.\n* Pigment reducing agents such as hydroquinone, azelaic acid, kojic acid, or a retinoid except for the retinol that is provided in this study.\n* Topicals that contain a nut oil or nut extract as part of their ingredient list.",true,"FEMALE","18 Years",{"count":82,"type":83},90,"ESTIMATED","INTERVENTIONAL",[86],"NA","Investigate the topical use of almond oil, almond oil augmented with 0.5% vitamin E, 0.025% tretinoin oil augmented with castor oil on the appearance of facial fine lines and wrinkles, pigmentation, hydration, trans-epidermal water loss, and sebum excretion rate.",[89,90,91,92,93],"Collagen Degeneration","Wrinkle","Pigmentation","Elastic Skin","Sebum Deficiency",[95,96,97,91],"Facial Wrinkles","Skin biophysical properties","Photoaging","2024-08-26",{"date":100,"type":101},"2024-08-28","ACTUAL",{"date":103,"type":101},"2024-07-22",{"date":105,"type":83},"2025-07-22",{"name":5,"class":6},1]