The Impact of Biological Mechanisms of Aging on Response Variability to Resistance Training in Older Adults
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age65+
SponsorMayo Clinic
About this trial
To critically examine biological, clinical, and behavioral modulators of progressive resistance training-associated exercise response heterogeneity in physical function and whole-body metabolism in older adults.
Eligibility criteria
Qualifiers
aged greater than or equal to 65 years
sedentary (Community Healthy Activities Model Program for Seniors physical activity questionnaire to identify and exclude persons engaged in regular (125 min/week or more) moderate intensity physical activity
at risk for mobility disability score of less than or equal to 10 (but greater than 3) on the SPPB
willing to be randomized into HE or PRT
Disqualifiers
unwillingness to provide informed consent
participation in lifestyle or pharmacologic intervention trial or structured program of exercise training in the past 6 months
an SPPB score of less than or equal to 3
osteoarthritis or condition with joint pain limiting daily life activities
Trial design
Treatments tested in this trial
- Progressive Resistance Training
- Health Education
Treatment groups
300 Participants
are divided into 2 treatment groupsSponsors and collaborators
Mayo Clinic
Lead sponsor
National Institute on Aging (NIA)
Collaborator
Tufts University Jean Mayer USDA Human Nutrition Research Center on Aging
Collaborator
Source ClinicalTrials.gov