The Impact of Chronic E-Cigarette Usage on Microvascular Health
ConditionE-Cig Use
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-29
SponsorVirginia Commonwealth University
About this trial
The study is focused on investigating the mechanisms involved in microvascular health in subjects that use e-cigarettes frequently. To explore microvascular health, different techniques and compounds. For one of the tests, iontophoresis, the drug's use will be stored and handled as described by the approved IND and non-IDS plan.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Between 18 and 29 years of age
Used e-cigarettes with nicotine (≥3 times/week for ≥6 months)
Disqualifiers
17 years old and younger or 30 years old or older.
Former combustible tobacco user/ former smoker
Use of cigarettes for 15 days or more in the past 60 days
Use of other tobacco products (cigars, hookah, smokeless), marijuana and/or illicit or prescription drugs weekly or more frequently in the past 60 days
Trial population
Chronic e-cigs users and never users that are between 18 and 29 years of age.
Trial design
Design model
Cohort
Time perspective
Cross-sectional
Treatments tested in this trial
E-cig use
Other interventionBased on e-cigarette usage, participants will be divided into those who used e-cigarettes and those who did not use e-cigarettes
Treatment groups
44 Participants
are divided into 2 treatment groupsGroup A: Chronic e-cigs users1 intervention
Group B: Never Users1 intervention
Trial outcomes
Primary outcomes
1
Endothelial dependent dilation
Endothelial-dependent dilation will be assessed using laser doppler speckle contrast in both groups through the intervention
Time frame
Participation is one week2
Neurogenic response
Neurogenic response will be assessed using axon reflex in both groups through the intervention
Time frame
Participation is one weekSponsors and contacts
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Source ClinicalTrials.gov