[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100545635":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":15,"centralContacts":20,"locations":10,"responsibleParty":29,"collaborators":10,"id":33,"slug":10,"hasResults":34,"nctId":35,"briefTitle":36,"officialTitle":36,"acronym":10,"eligibilityCriteria":37,"healthyVolunteers":38,"sex":39,"minAge":40,"maxAge":41,"enrollmentInfo":42,"targetDuration":10,"studyType":45,"phases":10,"briefSummary":46,"conditions":47,"keywords":52,"overallStatus":59,"whyStopped":10,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":10},{"fullName":5,"class":6},"University Hospital Sestre Milosrdnice","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"Patients undergoing open rhinoplasty approach",null,"Patients undergoing open rhinoplasty approach, of which most of will be augmented by using autologous cartilage grafts.",{"label":13,"type":10,"description":14,"interventionNames":10},"Patients undergoing closed approach rhinoplasty.","Patients undergoing closed approach rhinoplasty of which only few will be augmented by using autologous cartilage grafts.",[16],{"name":17,"affiliation":18,"role":19},"Marko Velimir Grgić, MD, PhD","UHC Sestre milosrdnice","STUDY_CHAIR",[21,26],{"name":22,"role":23,"phone":24,"phoneExt":10,"email":25},"Mateo Čukman, MD","CONTACT","+385992642621","mateo.cukman@hotmail.com",{"name":17,"role":23,"phone":27,"phoneExt":10,"email":28},"+385993787059","marko_grgic@yahoo.com",{"type":30,"investigatorFullName":31,"investigatorTitle":32,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Mateo Čukman","medical doctor, resident","100545635",false,"NCT06384469","The Impact of Rhinoplasty Approach and Used Autologous Cartilage Grafts on the Nasal Skin-soft Tissue Envelope Metabolism","Inclusion Criteria:\n\n* Adult patients undergoing primary functional rhinoplasty who comply with the study\n* Adult patients undergoing primary functional rhinoplasty who have singed the informed consent, previously approved by the ethics commitee.\n\nExclusion Criteria: -\n\n* patients with previous surgical procedures to the nose\n* patients with greater previous injury or burns to the nasal skin\n* patients with autoimmune skin conditions\n* patients with significant cardiovascular diseases\n* patients unwilling to comply with the study\n* patients who do not want to sign the informed consent, previously approved by the ethics commitee.",true,"ALL","18 Years","80 Years",{"count":43,"type":44},100,"ESTIMATED","OBSERVATIONAL","This is a prospective observation cohort investigation. Patients, that is participants, undergoing primary functional rhinoplasty will be evaluated in terms of measuring capillary blood lactic acid concentration in the nasal skin-soft tissue envelope immediately after the procedure and 7 days after the procedure.\n\nThe aim of our study is to test whether or not different rhinoplasty approaches and volume of the used autologous cartilage grafts impact the nasal skin-soft tissue metabolism.",[48,49,50,51],"Rhinoplasty","Nasal Skin-soft Tissue Envelope Metabolism","Lactic Acid","Autologous Cartilage Grafting",[53,54,55,56,57,58],"Open rhinoplasty approach","Closed rhinoplasty approach","Lactic acid","Skin-soft tissue envelope","Metabolism","Autologous cartilage grafting","NOT_YET_RECRUITING","2024-04-25",{"date":62,"type":63},"2024-04-29","ACTUAL",{"date":65,"type":44},"2025-01-02",{"date":67,"type":44},"2026-09-01",{"name":5,"class":6}]