[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100563366":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":29,"locations":35,"responsibleParty":55,"collaborators":58,"id":64,"slug":18,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":18,"eligibilityCriteria":69,"healthyVolunteers":65,"sex":70,"minAge":71,"maxAge":72,"enrollmentInfo":73,"targetDuration":18,"studyType":76,"phases":77,"briefSummary":79,"conditions":80,"keywords":82,"overallStatus":38,"whyStopped":18,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":97},{"fullName":5,"class":6},"University of Washington","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Vaginal washing cessation (intervention)","EXPERIMENTAL","The intervention will consist of 3 small-group educational sessions focused on vaginal washing cessation.",[13],"Behavioral: Vaginal washing cessation",{"label":15,"type":16,"description":17,"interventionNames":18},"Control","NO_INTERVENTION","Women in the control arm will return for weekly visits (to answer study questionnaires), but will not attend group educational sessions.",null,[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":18},"BEHAVIORAL","Vaginal washing cessation","Participants will attend weekly small group (\\~10 women per group) sessions that are structured using the transtheoretical model of behavioral change to promote vaginal washing cessation.",[9],[26],{"name":27,"affiliation":5,"role":28},"Michelle Sabo, Md, PhD","PRINCIPAL_INVESTIGATOR",[30],{"name":31,"role":32,"phone":33,"phoneExt":18,"email":34},"Michelle Sabo, MD, PhD","CONTACT","206-685-4456","sabo@uw.edu",[36],{"facility":37,"status":38,"city":39,"state":18,"zip":18,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"Pwani Research Center","RECRUITING","Mombasa","Kenya","KE",{"type":43,"coordinates":44},"Point",[45,46],39.66359,-4.05466,{"lat":46,"lon":45},[49,52],{"name":50,"role":32,"phone":51,"phoneExt":18,"email":34},"Michelle C Sabo, MDPHD","4408217962",{"name":53,"role":32,"phone":18,"phoneExt":18,"email":54},"Fatma Mwidadi","fmwidadi@uw.edu",{"type":28,"investigatorFullName":56,"investigatorTitle":57,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"Michelle Sabo","Assistant Professor: School of Medicine, Allergy and Infectious Diseases",[59,62],{"name":60,"class":61},"National Institutes of Health (NIH)","NIH",{"name":63,"class":61},"Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)","100563366",false,"NCT06615232","The Impact of Vaginal Washing on Cervical Inflammation","The Impact of Vaginal Washing on Cervical Inflammation: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Reports vaginal washing beyond the introitus in the past week\n* Female, aged 18-50\n* Presence of a cervix\n* Informed consent obtained and form signed\n* HIV-seronegative\n* Non-pregnant (urine β-hCG negative)\n* Willing to abstain from sex for 14 days after biopsy\n* Post-menarche and pre-menopause\n\nExclusion Criteria:\n\n* \\\u003C3 months postpartum or current breastfeeding\n* Current menstruation (can enroll after menses)\n* History of bleeding disorder\n* Visible cervical abnormality requiring evaluation\n* Medical contraindication to study protocol\n* Visible cervicovaginal ulcers or lesions\n* Positive test for gonorrhea, chlamydia, trichomonas, or wet preparation and examination findings indicating vulvovaginal candidiasis","FEMALE","18 Years","50 Years",{"count":74,"type":75},122,"ESTIMATED","INTERVENTIONAL",[78],"NA","Vaginal washing is a common practice that many women perceive as hygienic. However, vaginal washing has been linked to adverse reproductive health outcomes including increased HIV acquisition risk. The mechanism linking vaginal washing to HIV risk remains unknown, but may be related to increased inflammation caused by intravaginal washing practices. The primary objective of this study is to test the hypothesis that a vaginal washing cessation intervention will reduce concentrations of soluble inflammatory mediators in cervicovaginal fluid and total immune cells in mucosal tissue, reduce cervical epithelial disruption, and increase concentrations of protective vaginal Lactobacillus spp. compared to control.",[81],"Reproductive Behavior",[83,84,85,86,87],"sex work","hiv","vaginal washing","cervicovaginal inflammation","mucosal barrier disruption","2026-04-28",{"date":90,"type":91},"2026-05-05","ACTUAL",{"date":93,"type":91},"2025-05-16",{"date":95,"type":75},"2029-06",{"name":5,"class":6},1]