The ISAR InflEx Trial (Inflammation and Exercise)
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-45
SponsorDepartment of Cardiology German Heart Center Munich TUM University Hospital
About this trial
A sedentary lifestyle and obesity are associated with chronic low-grade inflammation and an elevated risk of cardiovascular disease (CVD). This study aims to systematically characterize and compare the effects of three distinct exercise modalities - moderate-intensity, vigorous-intensity, and short-duration maximal exercise - each differing in duration and intensity, on systemic inflammation and immune function. The study investigates the potential of exercise as an effective anti-inflammatory intervention for the prevention of CVD.
Eligibility criteria
Qualifiers
BMI 25.0 - 30.0 kg/m²
age 18 - 45 years
informed consent
no regular physical activity (≤1x/week of structured exercise)
Disqualifiers
any acute or chronic illness
pregnancy and breastfeeding
active smoking
Regular use of medication
Trial design
Treatments tested in this trial
- moderate-intensity exercise
- vigorous-intensity exercise
- short bouts of maximal exercise
Treatment groups
33 Participants
are divided into 3 treatment groupsSponsors and collaborators
Department of Cardiology German Heart Center Munich TUM University Hospital
Lead sponsor
The German Heart Foundation
Collaborator
Klinikum rechts der Isar Technische Universität München
Collaborator
Source ClinicalTrials.gov