About this trial
This approach utilizes accelerometry to measure NEA and electronic diaries for real-time psychological assessments, overcoming limitations of traditional methods such as retrospective bias and low ecological validity. Brief episodes of physical activity in daily life, which are distinctly different from structured exercise sessions, are generally linked to improved affective well-being. Notably, feelings of energy are particularly associated with incidental, unstructured, and non-exercise activities. Clinically, psychomotor retardation and diminished mood are key diagnostic features of MDD, with evidence suggesting that lower motor activity differentiates MDD patients from controls and that increased activity correlates with treatment response. In this context, the MASE project aims to design personalized BA interventions that focus on increasing NEA and, in turn, enhancing subjective energy levels to reduce depressive symptoms and prevent relapse.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Sufficient knowledge of the German language
Written informed consent.
Score > 15 on the Montgomery Asberg Depression rating scale (MADRS) for MDD group.
Remission within the past year and exhibit a MADRS score < 10 for at least one month for rMDD group
Disqualifiers
Pregnancy at baseline
Claustrophobia
Pacemaker
Artificial heart valves
Trial design
Parallel
Treatments tested in this trial
Non-exercise activity
BehavioralThe 5-week intervention to assess the effects of non-exercise activity on the activity-subjective energy association incorporates two high-intensity Ambulatory Assessment (AA) weeks at the beginning and end, with a tapered 3-week Ecological Momentary Intervention (EMI) phase in between. Momentary targeted micro interventions (JITAIs) with a Within-Person-Encouragement Design (WPED) are used to tailor the activity to the individual situation and phenotype of each participant.
Treatment groups
Trial outcomes
Primary outcomes
Change of real-life physical activity-subjective energy association
Subjective energy following target contexts will be assessed using the subscale Energetic Arousal from the MDMQ (VAS; scale from 0 to 100, with higher scores indicating higher energy levels).
Secondary outcomes
Change / stability in depressive symptoms in acute / remitted MDD patients
Depression severity will be evaluated using the MADRS on a 7-point Likert-scale (with higher scores indicating more depressive symptoms)
Sponsors and contacts
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University of Bern
Lead sponsor
University of Salzburg
Collaborator
University of Wuerzburg
Collaborator
University of Mannheim
Collaborator
University of Ostrava
Collaborator
University of Deusto
Collaborator