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Care",{"label":15,"type":10,"description":15,"interventionNames":16},"Tumor biopsy",[17],"Procedure: Tumor biopsy",{"label":19,"type":10,"description":20,"interventionNames":21},"Tumor resection","Maximal safe resection of the tumor",[22],"Procedure: Tumor resection",[24,29,32],{"type":25,"name":9,"description":11,"armGroupLabels":26,"otherNames":27},"BEHAVIORAL",[9],[28],"Best Supportive Care",{"type":30,"name":15,"description":15,"armGroupLabels":31,"otherNames":10},"PROCEDURE",[15],{"type":30,"name":19,"description":20,"armGroupLabels":33,"otherNames":10},[19],[35],{"name":36,"affiliation":5,"role":37},"Jasper Gerritsen, MD PhD","PRINCIPAL_INVESTIGATOR",[39,43],{"name":36,"role":40,"phone":41,"phoneExt":10,"email":42},"CONTACT","31107036130","j.gerritsen@erasmusmc.nl",{"name":44,"role":40,"phone":45,"phoneExt":10,"email":46},"Arnaud Vincent, MD PhD","31107034211","a.vincent@erasmusmc.nl",[48,65,78,91,107,118,131,143],{"facility":49,"status":50,"city":51,"state":52,"zip":53,"country":54,"countryCode":55,"cosmosGeoPoint":56,"geoPoint":61,"contacts":62},"University of California, San Francisco","RECRUITING","San Francisco","California","94143","United States","US",{"type":57,"coordinates":58},"Point",[59,60],-122.41942,37.77493,{"lat":60,"lon":59},[63],{"name":64,"role":40,"phone":10,"phoneExt":10,"email":10},"Mitchel Berger, MD PhD",{"facility":66,"status":50,"city":67,"state":68,"zip":69,"country":54,"countryCode":55,"cosmosGeoPoint":70,"geoPoint":74,"contacts":75},"Massachusetts General Hospital","Boston","Massachusetts","02114",{"type":57,"coordinates":71},[72,73],-71.05977,42.35843,{"lat":73,"lon":72},[76],{"name":77,"role":40,"phone":10,"phoneExt":10,"email":10},"Brian Nahed, 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Heidelberg","Heidelberg",{"type":57,"coordinates":111},[112,113],8.69079,49.40768,{"lat":113,"lon":112},[116],{"name":117,"role":40,"phone":10,"phoneExt":10,"email":10},"Christine Jungk, Dr. med.",{"facility":5,"status":50,"city":119,"state":120,"zip":121,"country":122,"countryCode":123,"cosmosGeoPoint":124,"geoPoint":128,"contacts":129},"Rotterdam","South Holland","3015 GD","Netherlands","NL",{"type":57,"coordinates":125},[126,127],4.47917,51.9225,{"lat":127,"lon":126},[130],{"name":36,"role":40,"phone":10,"phoneExt":10,"email":10},{"facility":132,"status":50,"city":133,"state":120,"zip":134,"country":122,"countryCode":123,"cosmosGeoPoint":135,"geoPoint":139,"contacts":140},"Haaglanden Medical Centre","The Hague","2512 VA",{"type":57,"coordinates":136},[137,138],4.29861,52.07667,{"lat":138,"lon":137},[141],{"name":142,"role":40,"phone":10,"phoneExt":10,"email":10},"Marike Broekman, MD PhD",{"facility":144,"status":93,"city":145,"state":10,"zip":146,"country":147,"countryCode":148,"cosmosGeoPoint":149,"geoPoint":153,"contacts":154},"Inselspital Universitätsspital Bern","Bern","3010","Switzerland","CH",{"type":57,"coordinates":150},[151,152],7.44744,46.94809,{"lat":152,"lon":151},[155],{"name":156,"role":40,"phone":10,"phoneExt":10,"email":10},"Philippe Schucht, MD PhD",{"type":158,"investigatorFullName":159,"investigatorTitle":160,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"SPONSOR_INVESTIGATOR","Jasper Gerritsen","Jasper K.W. Gerritsen MD PhD",[162,163,165,166,168,170,171],{"name":132,"class":6},{"name":164,"class":6},"Universitaire Ziekenhuizen KU Leuven",{"name":108,"class":6},{"name":167,"class":6},"Technical University of Munich",{"name":169,"class":6},"Insel Gruppe AG, University Hospital Bern",{"name":66,"class":6},{"name":49,"class":6},"100527359",false,"NCT06146738","The PALSUR-study: Palliative Care Versus Surgery in High-grade Glioma Patients (ENCRAM 2203)","PALSUR","Inclusion Criteria:\n\n1. Age ≥18 years and ≤90 years\n2. Tumor diagnosed as HGG (WHO grade III\u002FIV) on MRI as assessed by the neurosurgeon\n3. Written informed consent\n\nExclusion Criteria:\n\n1. Tumors of the cerebellum, brainstem or midline\n2. Inability to give written informed consent\n3. Secondary high-grade glioma due to malignant transformation from low-grade glioma\n4. Second primary malignancy within the past 5 years with the exception of adequately treated in situ carcinoma of any organ or basal cell carcinoma of the skin","ALL","18 Years","90 Years",{"count":182,"type":183},1015,"ESTIMATED","OBSERVATIONAL","There is no consensus on the optimal treatment of patients with high-grade glioma, especially when patients have limited functioning performance at presentation (KPS ≤70). Therefore, there are varied practice patterns around pursuing biopsy, resection, or palliation (best supportive care). This study aims to characterize the impact of palliative care versus biopsy versus resection on survival and quality of life in these patients. Also, it will aim to determine if there is a subset of patients that benefit the most from resection or biopsy, for which outcome, and how they could be identified preoperatively.\n\nThis study is an international, multicenter, prospective, 3-arm cohort study of observational nature. Consecutive HGG patients will be treated with palliative care, biopsy, or resection at a 1:3:3 ratio. Primary endpoints are: 1) overall survival, and 2) quality of life at 6 weeks, 3 months and 6 months after initial presentation based on the EQ-5D, EORTC QLQ C30 and EORTC BN 20 questionnaires. Total duration of the study is 5 years. Patient inclusion is 4 years, follow-up is 1 year.",[187,188,189,190],"Glioblastoma","Glioblastoma Multiforme","Glioblastoma, IDH-wildtype","Glioblastoma Multiforme, Adult",[192,193,194,195,196,197,187],"Palliative care","Best supportive care","Biopsy","Resection","Quality of life","Survival","2023-11-18",{"date":200,"type":201},"2023-11-27","ACTUAL",{"date":203,"type":201},"2023-01-01",{"date":205,"type":183},"2029-01-01",{"name":159,"class":6},8]