[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100553901":3},{"organization":4,"armGroups":7,"interventions":21,"overallOfficials":27,"centralContacts":32,"locations":38,"responsibleParty":55,"collaborators":17,"id":57,"slug":17,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":17,"eligibilityCriteria":62,"healthyVolunteers":63,"sex":64,"minAge":65,"maxAge":66,"enrollmentInfo":67,"targetDuration":17,"studyType":70,"phases":71,"briefSummary":73,"conditions":74,"keywords":81,"overallStatus":41,"whyStopped":17,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"First Affiliated Hospital of Zhejiang University","OTHER",[8,13,18],{"label":9,"type":6,"description":10,"interventionNames":11},"Healthy participants","Overall good health, with a BMI between 17 and 26; aged between 18 and 80 years; no complaints of cognitive impairment, normal neurological examination; signed informed consent form.",[12],"Behavioral: Sleep manipulation",{"label":14,"type":15,"description":16,"interventionNames":17},"Patients with mild cognitive impairment (MCI)","NO_INTERVENTION","Meets Petersen et al.'s diagnostic criteria for MCI: presence of subjective memory complaints; objective episodic memory impairment (scores on clinical memory tests falling 1-1.5 standard deviations below age- and education-adjusted norms); overall cognitive function is essentially normal, with a score of MMSE ≥ 24 indicating normal cognitive function according to the dementia screening standards specified by the Beijing Collaborative Group; CDR-global score = 0.5; daily living abilities are largely intact (capable of using public transportation, shopping, and managing finances). Does not meet the criteria for dementia according to the International Classification of Diseases, 10th edition (research version), or the National Institute of Neurological and Communicative Disorders and Stroke-Alzheimer's Disease and Related Disorders Association (NINCDS-ADRDA) criteria for probable Alzheimer's disease. Signed informed consent form.",null,{"label":19,"type":15,"description":20,"interventionNames":17},"Patients with Alzheimer's disease (AD)","Meets the NINCDS-ADRDA criteria for probable Alzheimer's disease; CDR-global score = 1; overall cognitive decline: MMSE score of 20-24; impaired daily living abilities: Activities of Daily Living (ADL) scale score \\> 26. Signed informed consent form.",[22],{"type":23,"name":24,"description":25,"armGroupLabels":26,"otherNames":17},"BEHAVIORAL","Sleep manipulation","This study will collect the MMSE results as a supplement to the MoCA. The sleep status of subjects will be screened using the Morningness-Eveningness Questionnaire (MEQ), Pittsburgh Sleep Quality Index (PSQI), and Epworth Sleepiness Scale (ESS).\n\nSubjects must maintain regular sleep and diet before sample collection. Peripheral blood samples will be taken the day before, the day of, and the day after acute sleep deprivation, whether experimentally induced (controlled) or naturally occurring (passive), along with assessment scales including anxiety and depression assessments.\n\nFor chronic sleep deprivation (≥7 days), blood samples will be collected before and after the deprivation period, with anxiety, depression, and cognitive assessments.\n\nExperimentally induced sleep deprivation takes place under controlled laboratory conditions, whereas passive sleep deprivation arises from external factors such as aging or shift work.",[9],[28],{"name":29,"affiliation":30,"role":31},"Benyan Luo","Zhejiang University","PRINCIPAL_INVESTIGATOR",[33],{"name":34,"role":35,"phone":36,"phoneExt":17,"email":37},"Benyan Luo, Prof","CONTACT","0571-87236537","luobenyan@zju.edu.cn",[39],{"facility":40,"status":41,"city":42,"state":43,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"The First Affiliated Hospital of Zhejiang University","RECRUITING","Hangzhou","Zhejiang","310000","China","CN",{"type":48,"coordinates":49},"Point",[50,51],120.16142,30.29365,{"lat":51,"lon":50},[54],{"name":34,"role":35,"phone":36,"phoneExt":17,"email":17},{"type":56,"investigatorFullName":17,"investigatorTitle":17,"investigatorAffiliation":17,"oldNameTitle":17,"oldOrganization":17},"SPONSOR","100553901",false,"NCT06492109","The Peripheral Blood Multi-Omics Study on Sleep Loss","The Peripheral Blood Multi-Omics Study on the Association of Sleep Loss With Aging and Alzheimer's Disease","Inclusion Criteria:\n\n1. Signed informed consent form；\n2. Meet the inclusion criteria for each arms.\n\nExclusion Criteria:\n\n1. Failure to provide informed consent;\n2. Inability to follow study procedures due to issues such as language barriers or cognitive impairment;\n3. Regular use of medications that may alter the relationship between sleep and outcome variables (e.g., opioid medications, benzodiazepines, and Z drugs \\[non-benzodiazepine hypnotics\\]);\n4. History of alcohol abuse, substance abuse, consciousness disorders, cerebrovascular disease, head injury, epilepsy, encephalitis, or other neurological disorders;\n5. Diagnosis of schizophrenia, severe depression, anxiety disorders, or other severe psychiatric conditions;\n6. Presence of severe arrhythmias, myocardial infarction within the last 6 months, severe pulmonary dysfunction, renal or hepatic insufficiency, severe anemia, severe gastrointestinal diseases, tumors, or other severe medical conditions.",true,"ALL","18 Years","80 Years",{"count":68,"type":69},60,"ESTIMATED","INTERVENTIONAL",[72],"NA","Sleep plays a role in cognitive processes such as memory processing, attention processing, and overall cognitive function. In recent years, the bidirectional relationship between sleep loss and aging, as well as related neurodegenerative diseases, has garnered widespread attention. Sleep disorders are a typical clinical manifestation of neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease and are closely related to the progression of these diseases. However, current research has yet to fully elucidate the physiological responses to sleep loss across different ages and cognitive levels, as well as the association and molecular basis between sleep loss, aging, and neurodegenerative diseases. This study aims to comprehensively characterize the transcriptional and metabolic changes in peripheral blood under sleep loss in populations of different ages and cognitive levels using multi-omics approaches and to preliminarily explore the role of sleep loss in aging and AD.",[75,76,77,78,79,80],"Sleep Deprivation","Aging","Alzheimer Disease","Healthy Lifestyle","Cognitive Decline","Shift-work Disorder",[82,83,84,85,86],"sleep loss","multi-omics","Metabolome","aging","alzheimer's disease","2025-07-30",{"date":89,"type":90},"2025-07-31","ACTUAL",{"date":92,"type":90},"2024-06-20",{"date":94,"type":69},"2025-12-31",{"name":5,"class":6},1]