The Therapeutic Effects of Dextrose Injection for Myofascial Pain Syndrome

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age20+
SponsorNational Cheng-Kung University Hospital

About this trial

Patients with an myofascial trigger point (MTrP) in their upper trapezius will be divided into three groups: Group A receiving MTrP injection with normal saline (control group), Group B with hypo-osmolar dextrose (5% dextrose), and Group C with hyper-osmolar dextrose (15% dextrose). Clinical outcomes and morphological changes will be measured before the injection, one hour after, one week after, two weeks after, and one month after the injection to delineate the therapeutic effects of dextrose injection for an MTrP.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

1). Patients should be 20 years of age or older;

2). They are able to communicate freely;

(a). a localized tender spot in a palpable taut band of muscle fibers,

(b). recognized pain (as the usual clinical complaint) when the tender spot is compressed,

Disqualifiers

(1). acute or serious medical problems;

(2). cognitive impairment or psychiatric disorder;

(3). coagulopathy or any other bleeding disorder;

(4). taking medication of anticoagulation or antithrombolytics;

Trial design

Design model

Parallel

Treatments tested in this trial

  • normal saline

    Other intervention

    Inject 2 ml normal saline into a myofascial trigger point and evaluate the clinical effects before and after the injection.

  • Dextrose 5% in water

    Drug

    Inject 2 ml 5% dextrose into a myofascial trigger point and evaluate the clinical effects before and after the injection.

  • Dextrose 15% in water

    Drug

    Inject 2 ml 15% dextrose into a myofascial trigger point and evaluate the clinical effects before and after the injection.

Treatment groups

30 Participants
are divided into 3 treatment groups
Group A: Normal salinePlacebo comparator 1 intervention
Group B: hypo-osmolar dextrose solutionExperimental treatment 1 intervention
Group C: hyper-osmolar dextrose solutionExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

visual analog scale (VAS)

To measure the pain intensity of a myofascial trigger point. The minimum value is 0, and the maximum value is 10, and higher scores mean worse outcome (more painful).

Time frame
Change from Baseline visual analog scale at one hour after intervention.
2

visual analog scale (VAS)

To measure the pain intensity of a myofascial trigger point. The minimum value is 0, and the maximum value is 10, and higher scores mean worse outcome (more painful).

Time frame
Change from Baseline visual analog scale at one week after intervention.
3

visual analog scale (VAS)

To measure the pain intensity of a myofascial trigger point. The minimum value is 0, and the maximum value is 10, and higher scores mean worse outcome (more painful).

Time frame
Change from Baseline visual analog scale at two weeks after intervention.
4

visual analog scale (VAS)

To measure the pain intensity of a myofascial trigger point. The minimum value is 0, and the maximum value is 10, and higher scores mean worse outcome (more painful).

Time frame
Change from Baseline visual analog scale at one month after intervention.

Secondary outcomes

1

pressure pain threshold (PPT)

To measure the change of pressure pain threshold of a myofascial trigger point. The minimum value is 0 Kg/cm2, the maximum value is 5 Kg/cm2, and higher scores mean better outcome (less painful).

Time frame
Change from Baseline pressure pain threshold at one hour after intervention.
2

pressure pain threshold (PPT)

To measure the change of pressure pain threshold of a myofascial trigger point. The minimum value is 0 Kg/cm2, the maximum value is 5 Kg/cm2, and higher scores mean better outcome (less painful).

Time frame
Change from Baseline pressure pain threshold at one week after intervention.
3

pressure pain threshold (PPT)

To measure the change of pressure pain threshold of a myofascial trigger point. The minimum value is 0 Kg/cm2, the maximum value is 5 Kg/cm2, and higher scores mean better outcome (less painful).

Time frame
Change from Baseline pressure pain threshold at two weeks after intervention.
4

pressure pain threshold (PPT)

To measure the change of pressure pain threshold of a myofascial trigger point. The minimum value is 0 Kg/cm2, the maximum value is 5 Kg/cm2, and higher scores mean better outcome (less painful).

Time frame
Change from Baseline pressure pain threshold at one month after intervention.

Other outcomes

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