[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100580602":3},{"organization":4,"armGroups":7,"interventions":17,"overallOfficials":11,"centralContacts":25,"locations":11,"responsibleParty":31,"collaborators":11,"id":35,"slug":11,"hasResults":36,"nctId":37,"briefTitle":38,"officialTitle":39,"acronym":40,"eligibilityCriteria":41,"healthyVolunteers":36,"sex":42,"minAge":43,"maxAge":44,"enrollmentInfo":45,"targetDuration":11,"studyType":48,"phases":49,"briefSummary":51,"conditions":52,"keywords":11,"overallStatus":54,"whyStopped":11,"lastUpdateSubmitDate":55,"lastUpdatePostDateStruct":56,"startDateStruct":59,"completionDateStruct":61,"leadSponsor":63,"locationsCount":11},{"fullName":5,"class":6},"Cairo University","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":11},"painful cases with disc displacement with reduction","ACTIVE_COMPARATOR",null,{"label":13,"type":14,"description":11,"interventionNames":15},"painful cases of disc displacement with reduction","EXPERIMENTAL",[16],"Other: hypertonic saline 5% sodium chloride",[18,22],{"type":6,"name":19,"description":20,"armGroupLabels":21,"otherNames":11},"hypertonic saline 5% sodium chloride","Hypertonic saline acts as an analgesic by alleviating nociceptive pain from inflamed tissues, which may include bone, connective tissue , synovium , or a combination of these Hypertonic saline results in safe and remarkable outcomes on knee pain, stiffness and function compared with intra-articular dextrose injection",[13],{"type":6,"name":23,"description":24,"armGroupLabels":11,"otherNames":11},"hypertonic dextrose 20%","A recent study showed the sensorineural analgesic effect of 5% dextrose prolotherapy in the treatment of chronic low back pain ,Therefore, the mechanism of action for dextrose prolotherapy is hypothesized to work through reducing peripheral sensitization and targeting structural dysfunction",[26],{"name":27,"role":28,"phone":29,"phoneExt":11,"email":30},"aya allah gamal salah, bachelors degree","CONTACT","+20 1005557843","ayaallah.gamal@dentistry.cu.edu.eg",{"type":32,"investigatorFullName":33,"investigatorTitle":34,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"PRINCIPAL_INVESTIGATOR","Aya Allah Gamal Salah","Aya Allah Gamal","100580602",false,"NCT06839430","Therapeutic Effect of Using Injectable Hypertonic Saline 5% Versus Injectable Dextrose 20% on Pain in Painful Cases of Disc Displacement With Reduction","Therapeutic Effect of Using Injectable Hypertonic Saline 5% Versus Injectable Dextrose 20% on Pain in Painful Cases of Disc Displacement With Reduction ( A Randomized Clinical Trial)","RCT","Inclusion Criteria:\n\n* presence of one or more of the following observations in one or both temporomandibular joints:\n\n  1. pain.\n  2. audible clicking.\n  3. mandibular deviation on opening.\n  4. Failure of conservative treatment\n\nExclusion Criteria:\n\n* The clinical or radiographic signs of disc displacement without reduction, osteoarthritis, or articular bony changes.\n\n  * Previous TMJ surgery, arthrocentesis, , or the presence of any systemic disease that would affect the TMJ anatomy or mechanical function.\n  * A history of allergic reactions to any components of the injectable solution.\n  * Infection of the affected joint and pre-auricular area.\n  * Previous surgery of the affected joint","ALL","15 Years","75 Years",{"count":46,"type":47},20,"ESTIMATED","INTERVENTIONAL",[50],"NA","This study is aiming to assess effect of hypertonic saline 5% in comparison to dextrose 20% on pain ,inter-insical opening and movements of jaw in painful cases of disc displacement with reduction",[53],"TMJ Disc Displacement With Reduction","NOT_YET_RECRUITING","2025-03-06",{"date":57,"type":58},"2025-03-07","ACTUAL",{"date":60,"type":47},"2025-08-20",{"date":62,"type":47},"2026-09-20",{"name":5,"class":6}]