Therapy Adjustment and IndividuaLized Response With Biomarker Observation in ReaL-world Heart Failure
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorMaastricht University Medical Center
About this trial
The goal of TAILOR-HF is to integrate clinical data, laboratory parameters, treatment patterns, and circulating biomarkers to identify factors that predict individual response to pharmacological treatment in patients with heart failure.
TAILOR-HF is an observational study with protocol-mandated assessments scheduled at baseline and at 1, 3, and 6 months after enrolment. Additional follow-up data will be collected through telephone visits every 6 months until the last participant has completed the protocol-mandated 6-month visit.
Eligibility criteria
Qualifiers
Provide written and dated informed consent for participation prior to trial admission,
Age ≥18 years, female or male
A clinical diagnosis of new onset or worsening of heart failure with a left-ventricular ejection fraction of <50%
On treatment with oral or i.v. furosemide ≥40 mg/day or equivalent (bumetanide 1mg, torasemide 10mg)
Disqualifiers
Scheduled or on renal replacement therapy,
Clearly documented intolerance to two or more of the following groups of drugs: BB, ARNI, SGLT2i or MRAs.
Diagnosis of peripartum cardiomyopathy, chemotherapy induced cardiomyopathy, current viral myocarditis, right heart failure in absence of left-sided structural disease, pericardial constriction, genetic hypertrophic cardiomyopathy, or infiltrative cardiomyopathy including amyloidosis.
The presence of a mechanical assist device,
Trial design
Treatments tested in this trial
- Not listed
Trial groups
600 Participants
are grouped into 1 trial groupLocations
Sponsors and collaborators
Maastricht University Medical Center
Lead sponsor
UMCG, University Hospital (Groningen, The Netherlands)
Collaborator
Leiden University Medical Center
Collaborator
Erasmus Medical Center
Collaborator
Uniklinik RTWH Aachen
Collaborator
Charite University, Berlin, Germany
Collaborator
Ospedale San Donato
Collaborator
Fidenza Hospital
Collaborator
Desio Hospital
Collaborator
Gorizia Hospital
Collaborator
UZ Antwerpen
Collaborator
Medizinischen Universität Wien
Collaborator
University College Dublin
Collaborator
University of Ulster
Collaborator
University of Glasgow
Collaborator
Source ClinicalTrials.gov