[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100313324":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":13,"centralContacts":18,"locations":25,"responsibleParty":42,"collaborators":10,"id":44,"slug":10,"hasResults":45,"nctId":46,"briefTitle":47,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":45,"sex":50,"minAge":51,"maxAge":10,"enrollmentInfo":52,"targetDuration":10,"studyType":55,"phases":10,"briefSummary":56,"conditions":57,"keywords":60,"overallStatus":28,"whyStopped":10,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":72},{"fullName":5,"class":6},"Fondation Ophtalmologique Adolphe de Rothschild","NETWORK",[8,11],{"label":9,"type":10,"description":10,"interventionNames":10},"Severe eye dryness",null,{"label":12,"type":10,"description":10,"interventionNames":10},"absence of eye dryness",[14],{"name":15,"affiliation":16,"role":17},"Eric GABISON","Fondation Ophtalmologique A. de Rothschild","PRINCIPAL_INVESTIGATOR",[19],{"name":20,"role":21,"phone":22,"phoneExt":23,"email":24},"Amélie YAVCHITZ","CONTACT","01.48.03.64.33","+33","ayavchitz@for.paris",[26],{"facility":27,"status":28,"city":29,"state":10,"zip":30,"country":31,"countryCode":32,"cosmosGeoPoint":33,"geoPoint":38,"contacts":39},"Fondation Ophtalmologique A de Rothschild","RECRUITING","Paris","75019","France","FR",{"type":34,"coordinates":35},"Point",[36,37],2.3488,48.85341,{"lat":37,"lon":36},[40],{"name":15,"role":21,"phone":10,"phoneExt":10,"email":41},"egabison@for.paris",{"type":43,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100313324",false,"NCT03358979","Three-dimensional Analysis of EMMPRIN on Conjunctival Epithelial Cells Surface in Severe Dry Eye Syndrome (ALTESSE)","ALTESSE","Patients:\n\nInclusion criteria\n\n* 18 years and over\n* Severe eye dryness (grade 3 or 4) as defined by the International Dry Eye Work Shop (2007): Frequent symptoms, Impregnation of fluorescein at the conjunctival level, marked fluorescein staining at the corneal level, Tear Break Up Time ≤ 5 seconds (fluorescein test) Schirmer's test score without anesthesia ≤ 5mm at 5 minutes\n* Patients without eye treatment or patients undergoing long-term stable eye treatment for whom a new treatment is being introduced\n\nExclusion criteria - Known pregnancy or breastfeeding\n\nControl subjects:\n\nInclusion criteria\n\n\\- 18 years and over\n\nExclusion criteria\n\n* Wearer of contact lenses\n* Topical ocular treatment\n* Known pregnancy or breastfeeding","ALL","18 Years",{"count":53,"type":54},100,"ESTIMATED","OBSERVATIONAL","Modifications of cell surface markers (including EMMPRIN) were observed in conjunctival epithelial cells during dry eye syndrome ; this study aims to describe the modifications of the repartition of these cell surface markers before and after initiation of a treatment.",[58,59],"Conjunctival Diseases","Dry Eye Syndromes",[58,59,61,62],"Antigens","CD147","2025-12-02",{"date":65,"type":66},"2025-12-08","ACTUAL",{"date":68,"type":66},"2017-12-14",{"date":70,"type":54},"2027-03",{"name":5,"class":6},1]