Time to Clearance of Chlamydia Trachomatis and Neisseria Gonorrhoeae RNA After Treatment: a Prospective Cohort Study

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorUniversity Hospital, Strasbourg, France

About this trial

The aim of this study is to evaluate the negativation time of chlamydial and gonococcal PCRs after treatment for urogenital, oropharyngeal and anal infections.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

- Patients attending the Trait d'Union department at the Nouvel Hôpital Civil for PrEP consultations, AES or HIV infection.

Over 18 years of age

Male or female

Who have had an uncomplicated CT and/or NG infection treated with currently recommended therapies (Ceftriaxone 500mg DU for NG infections, Doxycycline 200mg per day for 1 week for rectal CT infections and Azithromycin 1g DU or Doxycycline 7 days for other CT infections).

Disqualifiers

- Complicated CT and/or NG infections: epididymitis, prostatitis, upper genital infection, extra-genital involvement (keratoconjunctivitis, arthritis, skin involvement, Fiessinger-Leroy-reiter syndrome, Fitz-Hugh-Curtis syndrome).

Interfering treatments and associated diseases: Severe immunosuppression (HIV infection with CD4 less than 200/mm3, chemotherapy in the last 6 months, active haemopathy, congenital immune deficiency, immunosuppressive treatment including corticosteroid therapy for more than 4 weeks or organ transplant.

Impossibility of giving the subject informed information (subject in an emergency situation, difficulties in understanding the subject, etc.).

Subject under court protection

Trial design

Design model

Single group

Treatments tested in this trial

  • Chlamydia trachomatis (CT) and/or Neisseria gonorrhoeae (NG) NAAT(s)

    Diagnostic test

    Test every week after the start of treatment, until NAAT negativation and up to a maximum of 4 weeks

Treatment groups

No treatment groups listed

Trial outcomes

Primary outcomes

1

Estimate the rate of negativation of NAATs performed at the various sites of CT infection

Time frame
4 weeks after initiation of treatment

Secondary outcomes

Other outcomes

Sponsors and contacts

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