[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100577715":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":28,"centralContacts":33,"locations":42,"responsibleParty":185,"collaborators":11,"id":187,"slug":11,"hasResults":188,"nctId":189,"briefTitle":190,"officialTitle":191,"acronym":192,"eligibilityCriteria":193,"healthyVolunteers":188,"sex":194,"minAge":195,"maxAge":11,"enrollmentInfo":196,"targetDuration":11,"studyType":199,"phases":200,"briefSummary":202,"conditions":203,"keywords":11,"overallStatus":77,"whyStopped":11,"lastUpdateSubmitDate":205,"lastUpdatePostDateStruct":206,"startDateStruct":209,"completionDateStruct":211,"leadSponsor":213,"locationsCount":214},{"fullName":5,"class":6},"Insel Gruppe AG, University Hospital Bern","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Total pancreatectomy (TP)","EXPERIMENTAL",null,[13],"Procedure: Total pancreatectomy (TP)",{"label":15,"type":16,"description":11,"interventionNames":17},"Pancreaticoduodenectomy (PD)","ACTIVE_COMPARATOR",[18],"Procedure: Partial pancreaticoduodenectomy (PD)",[20,24],{"type":21,"name":9,"description":22,"armGroupLabels":23,"otherNames":11},"PROCEDURE","The investigators perform TP in patients who undergo surgical resection of a malignant tumor in the pancreatic head.",[9],{"type":21,"name":25,"description":26,"armGroupLabels":27,"otherNames":11},"Partial pancreaticoduodenectomy (PD)","The investigators perform partial PD with anastomosis of the pancreas in patients who undergo surgical resection of a malignant tumor in the pancreatic head. This is the current standard procedure.",[15],[29],{"name":30,"affiliation":31,"role":32},"Anna S Wenning, MD, PhD","Department of Visceral Surgery and Medicine Inselspital, Bern University Hospital","PRINCIPAL_INVESTIGATOR",[34,38],{"name":30,"role":35,"phone":36,"phoneExt":11,"email":37},"CONTACT","+41 (0)31 632 71 41","annasilvia.wenning@insel.ch",{"name":39,"role":35,"phone":40,"phoneExt":11,"email":41},"Nadine Uebersax","+41 (0)31 684 33 69","nadine.uebersax@unibe.ch",[43,61,75,92,106,120,132,146,160,174],{"facility":44,"status":45,"city":46,"state":11,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"Department of General, Visceral and Transplantation Surgery, University Hospital Münster","NOT_YET_RECRUITING","Münster","48149","Germany","DE",{"type":51,"coordinates":52},"Point",[53,54],7.62571,51.96236,{"lat":54,"lon":53},[57],{"name":58,"role":35,"phone":59,"phoneExt":11,"email":60},"Prof. Dr. med. Andreas Pascher","+49 251 83 56304","sekretariatavtc@ukmuenster.de",{"facility":62,"status":45,"city":63,"state":11,"zip":64,"country":48,"countryCode":49,"cosmosGeoPoint":65,"geoPoint":69,"contacts":70},"Department of General and Visceral Surgery, University Hospital Ulm","Ulm","89081",{"type":51,"coordinates":66},[67,68],9.99155,48.39841,{"lat":68,"lon":67},[71],{"name":72,"role":35,"phone":73,"phoneExt":11,"email":74},"Prof. Dr. med. Emrullah Birgin","+49 731 500 53 501","emrullah.birgin@uniklinik-ulm.de",{"facility":76,"status":77,"city":78,"state":11,"zip":79,"country":80,"countryCode":81,"cosmosGeoPoint":82,"geoPoint":86,"contacts":87},"Department of General and Visceral Surgery, Kantonsspital Aarau","RECRUITING","Aarau","5001","Switzerland","CH",{"type":51,"coordinates":83},[84,85],8.04422,47.39254,{"lat":85,"lon":84},[88],{"name":89,"role":35,"phone":90,"phoneExt":11,"email":91},"PD Dr. med. Philipp Kron","+41 62 838 55 80","philipp.kron@ksa.ch",{"facility":93,"status":77,"city":94,"state":11,"zip":95,"country":80,"countryCode":81,"cosmosGeoPoint":96,"geoPoint":100,"contacts":101},"Department of Surgery, Kantonsspital Baden","Baden","5404",{"type":51,"coordinates":97},[98,99],8.30592,47.47333,{"lat":99,"lon":98},[102],{"name":103,"role":35,"phone":104,"phoneExt":11,"email":105},"Prof. Dr. med. Antonio Nocito","+41 56 486 30 02","antonio.nocito@ksb.ch",{"facility":107,"status":77,"city":108,"state":11,"zip":109,"country":80,"countryCode":81,"cosmosGeoPoint":110,"geoPoint":114,"contacts":115},"Department of Visceral Surgery, University Hospital Basel","Basel","4031",{"type":51,"coordinates":111},[112,113],7.57327,47.55839,{"lat":113,"lon":112},[116],{"name":117,"role":35,"phone":118,"phoneExt":11,"email":119},"Prof. Dr. med Adrian Billeter","+41 61 777 73 21","adrian.billeter@clarunis.ch",{"facility":121,"status":77,"city":122,"state":11,"zip":123,"country":80,"countryCode":81,"cosmosGeoPoint":124,"geoPoint":128,"contacts":129},"Inselspital, Bern University Hospital","Bern","3010",{"type":51,"coordinates":125},[126,127],7.44744,46.94809,{"lat":127,"lon":126},[130,131],{"name":30,"role":35,"phone":11,"phoneExt":11,"email":11},{"name":30,"role":32,"phone":11,"phoneExt":11,"email":11},{"facility":133,"status":77,"city":134,"state":11,"zip":135,"country":80,"countryCode":81,"cosmosGeoPoint":136,"geoPoint":140,"contacts":141},"Department of Visceral Surgery, University Hospital Geneva","Geneva","1205",{"type":51,"coordinates":137},[138,139],6.14569,46.20222,{"lat":139,"lon":138},[142],{"name":143,"role":35,"phone":144,"phoneExt":11,"email":145},"Prof. Dr. med. Christian Toso","+41 22 372 77 02","christian.toso@hug.ch",{"facility":147,"status":77,"city":148,"state":11,"zip":149,"country":80,"countryCode":81,"cosmosGeoPoint":150,"geoPoint":154,"contacts":155},"Department of General, Visceral, Endocrine and Transplantation Surgery, Kantonsspital St. Gallen","Sankt Gallen","9000",{"type":51,"coordinates":151},[152,153],9.37477,47.42391,{"lat":153,"lon":152},[156],{"name":157,"role":35,"phone":158,"phoneExt":11,"email":159},"PD Dr. med. Ignazio Tarantino","+41 71 494 13 12","ignazio.tarantino@h-och.ch",{"facility":161,"status":77,"city":162,"state":11,"zip":163,"country":80,"countryCode":81,"cosmosGeoPoint":164,"geoPoint":168,"contacts":169},"Department of Surgery, Stadtspital Triemli Zürich","Zurich","8063",{"type":51,"coordinates":165},[166,167],8.55,47.36667,{"lat":167,"lon":166},[170],{"name":171,"role":35,"phone":172,"phoneExt":11,"email":173},"Dr. med. Stefan Gutknecht","+41 44 416 43 61","stefan.gutknecht@stadtspital.ch",{"facility":175,"status":77,"city":162,"state":11,"zip":176,"country":80,"countryCode":81,"cosmosGeoPoint":177,"geoPoint":179,"contacts":180},"Department of Surgery and Transplantation, University Hospital Zürich","8091",{"type":51,"coordinates":178},[166,167],{"lat":167,"lon":166},[181],{"name":182,"role":35,"phone":183,"phoneExt":11,"email":184},"Prof. Dr. med. José Oberholzer","+41 44 255 33 00","jose.oberholzer@usz.ch",{"type":186,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100577715",false,"NCT06801899","ToPanc Trial: Survival After Total Versus Partial Pancreaticoduodenectomy for Adenocarcinoma of the Pancreatic Head, Distal Cholangiocarcinoma, and Ampullary Cancer","ToPanc Trial: Survival After Total Versus Partial Pancreaticoduodenectomy for Adenocarcinoma of the Pancreatic Head, Distal Cholangiocarcinoma, and Ampullary Cancer: a Multi-centric Randomized Controlled Trial","ToPanc","Inclusion Criteria:\n\n* Adult patients (age ≥ 18 years) scheduled to undergo PD for highly suspected or histologically proven, resectable pancreatic ductal adenocarcinoma (PDAC), distal cholangiocarcinoma (DCC), and\u002For ampullary cancer (pancreaticobiliary type)\n* Suspected pancreas anastomosis at high-risk for development of a postoperative pancreatic fistula (POPF) (grade \"D\" according to Schuh et al. (29): Estimation by CT scan, MRI, and\u002For Endoscopic Ultrasound\n* Written informed consent\n\nExclusion Criteria:\n\n* Duodenal carcinoma, ampullary cancer (intestinal type), neuroendocrine tumors, benign tumors, chronic pancreatitis\n* Medical conditions that do not allow appreciation of the nature, scope, and possible consequences of the trial as judged by the investigator\n* Pregnancy. A beta-Human Chorionic Gonadotropin (bHCG) pregnancy test must to be performed for women of child-bearing potential (defined as premenopausal women who have not undergone surgical sterilization)\n* Inability to follow the study procedures, e.g., due to psychological disorders, dementia, etc.","ALL","18 Years",{"count":197,"type":198},170,"ESTIMATED","INTERVENTIONAL",[201],"NA","The goal of this clinical trial is to learn if total removal of the pancreas is a preferable alternative to partial removal in patients with cancer of the pancreatic head who are at high risk of pancreatic leakage. The main question it aims to answer is:\n\nDoes total pancreas removal improve survival without reducing quality of life compared to partial removal?\n\nThe only study specific procedures are the collection of 2 blood samples (7.5ml for each time point, preoperatively and during the hospitalisation) and the completion of the questionnaires.",[204],"Pancreatic Cancer","2026-06-18",{"date":207,"type":208},"2026-06-23","ACTUAL",{"date":210,"type":208},"2026-06-01",{"date":212,"type":198},"2030-10",{"name":5,"class":6},10]