[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100601127":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":21,"centralContacts":25,"locations":32,"responsibleParty":45,"collaborators":49,"id":53,"slug":30,"hasResults":54,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":58,"eligibilityCriteria":59,"healthyVolunteers":60,"sex":61,"minAge":62,"maxAge":63,"enrollmentInfo":64,"targetDuration":30,"studyType":67,"phases":68,"briefSummary":70,"conditions":71,"keywords":73,"overallStatus":77,"whyStopped":30,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":87},{"fullName":5,"class":6},"University of Kentucky","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Acute Resistance Exercise","EXPERIMENTAL","Participants will perform four exercises: squat, knee extension, leg press, and lat pulldown at 80% of 1-RM (repetition maximum) determined during a previous visit.",[13],"Behavioral: Acute Resistance Exercise",[15],{"type":16,"name":9,"description":17,"armGroupLabels":18,"otherNames":19},"BEHAVIORAL","Participants will perform three sets of eight repetitions, with a 90-120 second rest between sets, with a fourth set performed to failure. All resistance exercise will be performed on pneumatic resistance devices (Keiser Sports Health Equipment, Fresno, CA).",[9],[20],"Strength Training",[22],{"name":23,"affiliation":5,"role":24},"Yuan Wen, MD, PhD","PRINCIPAL_INVESTIGATOR",[26],{"name":27,"role":28,"phone":29,"phoneExt":30,"email":31},"Yuan Wen, MD\u002FPhD","CONTACT","18592187185",null,"ywen2@uky.edu",[33],{"facility":5,"status":30,"city":34,"state":35,"zip":36,"country":37,"countryCode":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":30},"Lexington","Kentucky","40506","United States","US",{"type":40,"coordinates":41},"Point",[42,43],-84.47772,37.98869,{"lat":43,"lon":42},{"type":46,"investigatorFullName":47,"investigatorTitle":48,"investigatorAffiliation":5,"oldNameTitle":30,"oldOrganization":30},"SPONSOR_INVESTIGATOR","Yuan Wen","Assistant Professor",[50],{"name":51,"class":52},"National Institute of General Medical Sciences (NIGMS)","NIH","100601127",false,"NCT07106450","Training Induced Muscle-Adipose EV Communication","Muscle-derived Extracellular Vesicles and Their Interactions With Adipocytes in Human Metabolic Dysfunction","TIMER2","Inclusion Criteria:\n\n* Age 30-55 years\n* Sedentary lifestyle (exercise \\\u003C1 day\u002Fweek for at least 3 months prior to enrollment)\n* Able to provide informed consent\n* For Control Group: BMI \\\u003C 27 kg\u002Fm², normal glucose tolerance, no more than 1 feature of metabolic syndrome\n* For Prediabetic Group: BMI \\> 30 kg\u002Fm², at least 3 features of metabolic syndrome including prediabetes (defined as fasting plasma glucose 100-125 mg\u002FdL OR 2-hour post-load glucose on 75g OGTT 140-199 mg\u002FdL OR HbA1C 5.7-6.4%)\n\nExclusion Criteria:\n\n* Pregnancy (confirmed by pregnancy test in women of childbearing potential)\n* Type 2 diabetes mellitus\n* Cardiovascular contraindications to resistance exercise\n* Medical conditions that would interfere with muscle or adipose tissue biopsy procedures\n* Use of medications that significantly affect glucose metabolism or exercise response\n* Active participation in structured exercise programs (\\>1 day\u002Fweek) within 3 months of enrollment\n* Inability to safely participate in resistance exercise protocol",true,"ALL","30 Years","55 Years",{"count":65,"type":66},40,"ESTIMATED","INTERVENTIONAL",[69],"NA","This study examines how muscle cells communicate with fat cells through tiny packages called extracellular vesicles (EV) during exercise. These vesicles carry important molecules that may affect how the body processes sugar and fat. The research team observed significant variability in the adipose response to exercise, and used this variability to gain further insight into the mechanism through which mature microRNA-1 (miR-1) changes in adipose tissue. The investigators selected six subjects with the highest increase in miR-1 abundance in adipose tissue after exercise and compared them with the six subjects that had the most dramatic decrease in miR-1 abundance after exercise. The research team observed that participants intrinsically vary in their ability to endocytose EV into adipose tissue. It is unclear whether this variance in receptivity is a cause or consequence of the significant difference in EV-delivery of miR-1 to adipose tissue.",[72],"Prediabetes",[74,75,76],"muscle","extracellular vesicles","adipose","NOT_YET_RECRUITING","2026-06-08",{"date":80,"type":81},"2026-06-10","ACTUAL",{"date":83,"type":66},"2026-07",{"date":85,"type":66},"2028-09-30",{"name":47,"class":6},1]