Transcatheter vs. Surgical Treatment of Degenerative Mitral Regurgitation
ConditionDegenerative Mitral Valve Disease
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age60+
SponsorCedars-Sinai Medical Center
About this trial
The goal of this observational study is to compare the outcomes of transcatheter edge-to-edge repair (TEER) versus surgical mitral valve repair for degenerative mitral regurgitation (DMR) over the long term. The study aims to:
1. Evaluate the effectiveness and safety of TEER versus surgery in patients with DMR over long term. 2. Investigate the predictors of left ventricular dysfunction and clinical outcomes using advanced imaging techniques, such as cardiac MRI 3. Assess patient-reported recovery and quality of life outcomes using validated tools.
The study focuses on improving care strategies for patients with DMR, particularly those at higher surgical risk, by identifying optimal treatment approaches and predictors of recovery.
Eligibility criteria
Qualifiers
Patients older than 60 years who have DMR will be included in the study
Disqualifiers
Patients with prior history of mitral intervention or surgery will be excluded.
Patient records flagged "break the glass" or "research opt out" will be excluded.
Persons with allergy to animal dander or animal-instigated asthma will be excluded.
Trial design
Treatments tested in this trial
- Not listed
Trial groups
60 Participants
are grouped into 2 trial groupsSponsors and collaborators
Cedars-Sinai Medical Center
Lead sponsor
National Heart, Lung, and Blood Institute (NHLBI)
Collaborator
Source ClinicalTrials.gov