About this trial
This study is testing two different ways of treating atrial fibrillation (AF) in people who also have heart failure with mildly reduced or preserved heart function. Patients will randomly be assigned to either rhythm control using catheter ablation or rate control using medicines. The pilot phase will determine if a larger study can be successfully carried out to see which approach better improves survival, reduces hospitalizations, and enhances quality of life.
Eligibility criteria
Qualifiers
Age ≥18 years
Diagnosis of atrial fibrillation (documented on Holter, rhythm strip, or ECG)
New York Heart Association (NYHA) class II-III heart failure
Left ventricular ejection fraction (LVEF) >40%
Disqualifiers
Permanent atrial fibrillation diagnosis
Prior catheter ablation for atrial fibrillation
NYHA class IV heart failure
Rheumatic heart disease
Trial design
Treatments tested in this trial
- Catheter Ablation for Atrial Fibrillation
- Rate Control Medications (beta-blockers, calcium channel blockers, digoxin)
Treatment groups
Sponsors and collaborators
Nova Scotia Health Authority
Lead sponsor
Heart and Stroke Foundation of Canada
Collaborator