[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100577582":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":11,"centralContacts":27,"locations":33,"responsibleParty":82,"collaborators":11,"id":86,"slug":11,"hasResults":87,"nctId":88,"briefTitle":89,"officialTitle":89,"acronym":90,"eligibilityCriteria":91,"healthyVolunteers":87,"sex":92,"minAge":93,"maxAge":94,"enrollmentInfo":95,"targetDuration":11,"studyType":98,"phases":99,"briefSummary":101,"conditions":102,"keywords":106,"overallStatus":36,"whyStopped":11,"lastUpdateSubmitDate":108,"lastUpdatePostDateStruct":109,"startDateStruct":112,"completionDateStruct":114,"leadSponsor":116,"locationsCount":117},{"fullName":5,"class":6},"Lo.Li.Pharma s.r.l","INDUSTRY",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Treated Group HP+phD","EXPERIMENTAL",null,[13],"Dietary Supplement: myo-Inositol plus DIoscorea Villosa",{"label":15,"type":16,"description":17,"interventionNames":11},"Controls","NO_INTERVENTION","Not treated patients",[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"DIETARY_SUPPLEMENT","myo-Inositol plus DIoscorea Villosa","myo-Inositol + alpha-lactalbumin + folic acid once daily, Dioscorea Villosa + alpha-lactalbumin + Vitamin D twice daily",[9],[25,26],"myo-Inositol","Dioscorea Villosa",[28],{"name":29,"role":30,"phone":31,"phoneExt":11,"email":32},"Vittorio Unfer","CONTACT","(+39)06\u002F22442074","vunfer@gmail.com",[34,52,66],{"facility":35,"status":36,"city":37,"state":38,"zip":39,"country":38,"countryCode":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":47},"Zhordania and Khomasuridze Institute of Reproductology","RECRUITING","Tbilisi","Georgia","0112","GE",{"type":42,"coordinates":43},"Point",[44,45],44.83412,41.69143,{"lat":45,"lon":44},[48],{"name":49,"role":30,"phone":50,"phoneExt":11,"email":51},"Lali Pkhaladze","+995 599 58 41 09","lpkhaladze@yahoo.com",{"facility":53,"status":36,"city":54,"state":55,"zip":56,"country":55,"countryCode":57,"cosmosGeoPoint":58,"geoPoint":62,"contacts":63},"Agunco","Rome","Italy","00155","IT",{"type":42,"coordinates":59},[60,61],12.51133,41.89193,{"lat":61,"lon":60},[64],{"name":29,"role":30,"phone":65,"phoneExt":11,"email":32},"06 4050 0651",{"facility":67,"status":36,"city":68,"state":69,"zip":11,"country":70,"countryCode":71,"cosmosGeoPoint":72,"geoPoint":76,"contacts":77},"Department of Obstetrics and Gynecology with Reproductive Medicine, F.I. Inozemtsev Academy of Medical Education","Saint Petersburg","Russian Federation","Russia","RU",{"type":42,"coordinates":73},[74,75],30.31413,59.93863,{"lat":75,"lon":74},[78],{"name":79,"role":30,"phone":80,"phoneExt":11,"email":81},"Olga Pustotina","8 (916) 926 76 52","pustotina@gmail.com",{"type":83,"investigatorFullName":29,"investigatorTitle":84,"investigatorAffiliation":85,"oldNameTitle":11,"oldOrganization":11},"PRINCIPAL_INVESTIGATOR","Professor","AGUNCO Obstetrics and Gynecology Centre","100577582",false,"NCT06800170","Treatment of Menstrual Cycle Alterations in Adolescents","HP-phD_Adolesc","Inclusion Criteria:\n\n* adolescent women aged 14-19 years old, with at least 3 years passed after menarche, and oligomenorrhea or amenorrhea\n\nExclusion Criteria:\n\n* Primary amenorrhea.\n* Hyperandrogenism due to other factors (i.e. adrenal hyperplasia or Cushing syndrome).\n* Hyperprolactinemia or overt hypothyroidism (TSH ≥4).\n* Other hormonal alterations.\n* Ongoing hormonal therapies, including OCPs, six months before enrollment.\n* Ongoing pharmacological therapies.\n* Ongoing use of myo-Inositol supplement or other source of myo-Inositol, or Dioscorea villosa, six months before enrollment.","FEMALE","14 Years","19 Years",{"count":96,"type":97},20,"ESTIMATED","INTERVENTIONAL",[100],"NA","the aim of the present study is intended to evaluate how treatment with Myo-Inositol and Dioscorea Villosa can help improve menstrual cycle irregularities in adolescents, both with and without PCOS.",[103,104,105],"Amenorrhea","Oligomenorrhea","PCOS (Polycystic Ovary Syndrome)",[25,26,107],"adolescents","2026-01-05",{"date":110,"type":111},"2026-01-06","ACTUAL",{"date":113,"type":111},"2025-06-01",{"date":115,"type":97},"2026-12",{"name":5,"class":6},3]