[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100601396":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":26,"centralContacts":31,"locations":42,"responsibleParty":60,"collaborators":36,"id":64,"slug":36,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":36,"eligibilityCriteria":69,"healthyVolunteers":65,"sex":70,"minAge":71,"maxAge":72,"enrollmentInfo":73,"targetDuration":36,"studyType":76,"phases":77,"briefSummary":79,"conditions":80,"keywords":36,"overallStatus":45,"whyStopped":36,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":91},{"fullName":5,"class":6},"Aswan University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Group A: letrozole and Misoprostol","ACTIVE_COMPARATOR","About 35 pregnant women will receive aromatase inhibitor (letrozole) 2.5 mg tablet three times daily for 3 days followed by two doses of 400 micrograms of misoprostol administered vaginally on the 4th day of enrolment (two 200-μg tablets spaced 4 hours apart).",[13],"Drug: Letrozole 2.5mg",{"label":15,"type":10,"description":16,"interventionNames":17},"Group B: Misoprostol","About 35 pregnant women will receive two doses of 400 µg of vaginal misoprostol (two 200-μg tablets spaced 4 hours apart).",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"DRUG","Letrozole 2.5mg","to determine the effect of Letrozole as a premedication before misoprostol treatment used to induce missed miscarriage.",[9,15],[25],"Misoprestol",[27],{"name":28,"affiliation":29,"role":30},"Hani Ahmed Farouk, Assist.Prof.","Obstetrics and Gynecology,Faculty of Medicine,Aswan University","STUDY_CHAIR",[32,38],{"name":33,"role":34,"phone":35,"phoneExt":36,"email":37},"Arwa Ashraf Saeed, MSC","CONTACT","+201013302339",null,"Arwa170439@aswu.edu.eg",{"name":39,"role":34,"phone":40,"phoneExt":36,"email":41},"Hani Ahmed Farouk, Assist.prof","+201112501460","hany.farouk@aswu.edu.eg",[43],{"facility":44,"status":45,"city":46,"state":36,"zip":36,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"Aswan University Hospital","RECRUITING","Aswān","Egypt","EG",{"type":50,"coordinates":51},"Point",[52,53],32.89942,24.09082,{"lat":53,"lon":52},[56],{"name":57,"role":34,"phone":58,"phoneExt":36,"email":59},"Amr Shahata Abd Elbadee, Assist.Prof","+201007221659","Love_like902@yahoo.com",{"type":61,"investigatorFullName":62,"investigatorTitle":63,"investigatorAffiliation":5,"oldNameTitle":36,"oldOrganization":36},"PRINCIPAL_INVESTIGATOR","Arwa Ashraf Saeed","Demonstrator at Obstetrics and Gynecology, Faculty of medicine","100601396",false,"NCT07109947","Use of Aromatase Inhibitor Before Misoprostol in Medical Termination of Miscarriage","Comparison Between the Use of Aromatase Inhibitor Before Misoprostol and Use of Misoprostol Alone in Medical Termination of Miscarriage","Inclusion Criteria:\n\n* Missed or anembryonic pregnancy.\n* Gestational age from 4 weeks to 26 weeks of pregnancy (confirmed by ultrasound scanning on first day of admittance).\n* Hemoglobin level more than 9g\u002Fl.\n* Closed cervix.\n* No product of conception in the cervical canal.\n\nExclusion Criteria:\n\n* Previous attempt to terminate the pregnancy.\n* Molar pregnancy\n* Abnormal uterine lesions such as fibroids or congenital mal formations.\n* Pregnancy despite of intrauterine contraceptive device.\n* Medical disorders as cardiac, renal or hemorrhagic diseases.\n* BMI more than 35 kg\u002Fm2.\n* Known hypersensitivity to any of the medication used.","FEMALE","18 Years","45 Years",{"count":74,"type":75},70,"ESTIMATED","INTERVENTIONAL",[78],"NA","Abortion is one of the most common complications of pregnancy. Missed abortion is a type of abortions, occurs in 15%-20% of clinically diagnosed pregnancies and is defined as the retention of pregnancy products in the uterus for several days or weeks after death of the fetus.",[81],"Miscarriage","2025-07-31",{"date":84,"type":85},"2025-08-07","ACTUAL",{"date":87,"type":85},"2025-07-10",{"date":89,"type":75},"2025-12-10",{"name":5,"class":6},1]