[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100624988":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":21,"centralContacts":28,"locations":38,"responsibleParty":65,"collaborators":67,"id":71,"slug":20,"hasResults":72,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":20,"eligibilityCriteria":76,"healthyVolunteers":77,"sex":78,"minAge":79,"maxAge":80,"enrollmentInfo":81,"targetDuration":20,"studyType":84,"phases":85,"briefSummary":87,"conditions":88,"keywords":20,"overallStatus":90,"whyStopped":20,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":100},{"fullName":5,"class":6},"University of Pennsylvania","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"NR Arm","EXPERIMENTAL","All participants will receive NR 1000mg capsules to take by mouth daily for approximately 30 days.",[13],"Dietary Supplement: Oral NR Supplementation",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"DIETARY_SUPPLEMENT","Oral NR Supplementation","Oral Nicotinamide Riboside (NR)",[9],null,[22,25],{"name":23,"affiliation":5,"role":24},"Ravinder Reddy, Ph.D.","PRINCIPAL_INVESTIGATOR",{"name":26,"affiliation":5,"role":27},"Joseph A. Baur, Ph.D.","STUDY_DIRECTOR",[29,34],{"name":30,"role":31,"phone":32,"phoneExt":20,"email":33},"Damodar Reddy","CONTACT","215-898-9357","cdamodar@pennmedicine.upenn.edu",{"name":35,"role":31,"phone":36,"phoneExt":20,"email":37},"Jordan Maddox, BA","215-898-3694","jordan.maddox@pennmedicine.upenn.edu",[39,60],{"facility":40,"status":20,"city":41,"state":42,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"Penn Medicine","Philadelphia","Pennsylvania","19104-6006","United States","US",{"type":47,"coordinates":48},"Point",[49,50],-75.16362,39.95238,{"lat":50,"lon":49},[53,57,58],{"name":54,"role":31,"phone":55,"phoneExt":20,"email":56},"Mark Elliott, Ph.D","215-898-8648","melliott@upenn.edu",{"name":30,"role":31,"phone":32,"phoneExt":20,"email":33},{"name":26,"role":59,"phone":20,"phoneExt":20,"email":20},"SUB_INVESTIGATOR",{"facility":5,"status":20,"city":41,"state":42,"zip":61,"country":44,"countryCode":45,"cosmosGeoPoint":62,"geoPoint":64,"contacts":20},"19104",{"type":47,"coordinates":63},[49,50],{"lat":50,"lon":49},{"type":66,"investigatorFullName":20,"investigatorTitle":20,"investigatorAffiliation":20,"oldNameTitle":20,"oldOrganization":20},"SPONSOR",[68],{"name":69,"class":70},"National Institute on Aging (NIA)","NIH","100624988",false,"NCT07416786","Validation of NAD+ Measurements for Human Clinical Studies","Validation of NAD+ Measurements for Human Clinical Studies: Multi-method Inter-laboratory Standardization","* Male or female age18-35 years or 70 years or older, healthy\n* if female reproductive potential, use of highly effective contraception (at least 1 month prior to screening and during study participation).\n* No known sensitivity to NR\n* No use of niacin, blood thinners or chemotherapy agents\n* HbA1c below 8.5% and not diabetec requiring insulin.\n* Not using\u002Ftaking corticosteroids\n* No laboratory abnormalities indicating significant anemia, bleeding risk, kidney disease, or liver disease\n* No contraindication to MRI\n* Not Pregnant, lactating, or planning to become pregnant during participation\n* Not taking multivitamins or any over-the-counter supplements except calcium and vitamin D (any other supplements - discontinued 2 weeks prior to study participation).\n* not taking\u002F undergoing another investigational drug or other intervention within the past 30 days.",true,"ALL","18 Years","110 Years",{"count":82,"type":83},48,"ESTIMATED","INTERVENTIONAL",[86],"NA","The purpose of this study is to determine nicotinamide adenine dinucleotide (NAD) levels in healthy adult subjects before and after supplementing with over-the counter nicotinamide riboside (NR) using magnetic resonance spectroscopy (MRS).",[89],"Healthy Adults","NOT_YET_RECRUITING","2026-06-02",{"date":93,"type":94},"2026-06-03","ACTUAL",{"date":96,"type":83},"2026-07-01",{"date":98,"type":83},"2028-07-31",{"name":5,"class":6},2]