Weaning From Mechanical Ventilation in Patients With Acute Brain Injury
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorSoutheast University, China
About this trial
Acute brain injury (ABI) patients frequently necessate intubation and invasive mechanical ventilation (IMV). While some ABI patients are capable of breathing spontaneously, which is one of the main criteria of extubation and weaning. However, the rate of extubation failure was significantly higher in ABI patients compared with non-neurological critical care patients. In patients who have failed one or several trials of extubation, tracheostomy is recommend according to the latest ESICM consensus. Tracheostomy can enhance comfort, improve pulmonary hygiene and decrease sedation requirement, which could facilitate the liberation from ventilator.
Numerous studies have explored the causes of weaning failure and provide various predictive models in guiding extubation and tracheostomy. Yet, due to limitations of such as small sample size or a lack of external validation, there is paucity of practical weaning algorithm tailored for ABI patients. The liberation from IMV in ABI patients still remains challenging with poor level of evidence in current guidelines or expert consensus.
We aim to describe the weaning outcomes in ABI patients, and further investigate the potential predictors of weaning success in ABI patients.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
acute brain injury
age >=18 years
invasive mechanical ventilation for at least 24 hours
Disqualifiers
tracheostomized before ICU admission
pregnant or lactation
with cervical spinal cord injury
decision to receive palliative care within 24 hours of ICU admission
Trial population
All patients admitted to the ICU due to acute brain injury and treated with invasive mechanical ventilation
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Not listed
Trial groups
No trial groups listed
Trial outcomes
Primary outcomes
1
weaning success
successfully weaned from invasive ventilation according to WIND classification
Time frame
up to 7-day period (ICU stay)Secondary outcomes
1
extubation
Extubation without the need for reintubation or death within a 7-day period, or upon ICU discharge, whichever occurs first
Time frame
up to 7-day period (ICU stay)Other outcomes
1
tracheostomy
tracheostomy during ICU stay
Time frame
up to 7-day period (ICU stay)Sponsors and contacts
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Source ClinicalTrials.gov