Coronary Heart Disease (CHD) is an ischemic heart disease caused by coronary atherosclerosis, and it is the leading cause of death from cardiovascular diseases worldwide. Weight loss in obese patients can significantly improve metabolic indicators such as dyslipidemia and insulin resistance; therefore, weight loss may become a target for improving the prognosis of obese patients with coronary heart disease. This study is a multicenter, randomized controlled clinical trial aimed at evaluating the effect of software-based healthy weight loss guidance (personalized diet + exercise intervention) in obese patients with coronary heart disease. It is expected that 136 patients will be enrolled in hospitals including Guangdong Provincial People's Hospital, with a total study duration of 1 year.
Age range: 18-65 years old .
History of coronary heart disease confirmed by coronary angiography or coronary CTA, showing ≥50% stenosis in at least one major coronary artery (left main coronary artery, left anterior descending artery, left circumflex artery, right coronary artery); or a definite history of myocardial infarction, or prior coronary revascularization (PCI or CABG).
BMI: Body Mass Index (BMI) ≥ 28 kg/m²
Weight loss willingness: Has the intention to lose weight
Unstable angina pectoris or acute myocardial infarction occurring within the previous month;
Comorbid endocrine or neurological diseases, cancer, or a history of bariatric surgery that affect body weight; or long-term use of medications that impact body weight;
Comorbid diseases that affect exercise capacity, such as severe cardiopulmonary diseases or osteoarthritic conditions;
Comorbid diseases that affect diet, such as severe mental disorders, bulimia or anorexia nervosa, or cognitive dysfunction;
Guangdong Provincial People's Hospital
Lead sponsor
Yuebei People's Hospital
Collaborator
Guangzhou Red Cross Hospital
Collaborator
Zhongshan Hospital Of Traditional Chinese Medicine
Collaborator
Shenzhen Nanshan Institute of Chronic Disease Control
Collaborator
Dongguan Binhaiwan Central Hospital
Collaborator
The Eighth People's Hospital of Nanning
Collaborator
People's Hospital of Xinjiang Uygur Autonomous Region
Collaborator
Nanyang Central Hospital
Collaborator
The First People's Hospital of Yunnan
Collaborator
The First People's Hospital of Nanning
Collaborator