[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Amjad Alwaal, MD, MSc, FRCSC, FACS\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":46},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":10,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":5},"100631530",false,"NCT07501884","REDUCER Trial (TXA in Urethroplasty)","Reduction of Perioperative Blood Loss in Urethral Reconstruction Using Tranexamic Acid (REDUCER Trial): A Multicenter Pragmatic Randomized Study","REDUCER","Inclusion Criteria:\n\n* Adult patients (≥18 years old)\n* Undergoing urethroplasty for urethral stricture disease\n* Ability to provide informed consent\n\nExclusion Criteria:\n\n* Known contraindication to tranexamic acid (TXA)\n* History of thromboembolic disease (e.g., deep vein thrombosis, pulmonary embolism, stroke)\n* Known bleeding disorder or coagulopathy\n* Current use of anticoagulation that cannot be safely held perioperatively\n* Severe renal impairment\n* Allergy or hypersensitivity to tranexamic acid\n* History of seizures\n* Inability to provide informed consent","MALE","18 Years",{"count":19,"type":20},40,"ESTIMATED","INTERVENTIONAL",[23],"PHASE4","This study will test whether tranexamic acid (TXA), a medication used to reduce bleeding, can decrease blood loss in patients having urethroplasty. Participants will be randomly assigned to receive either a single intravenous dose of TXA at the start of anesthesia or standard care without TXA. Researchers will compare hemoglobin change after surgery as well as estimated blood loss and complications.",[26,27],"Urethral Stricture","Urethral Diseases",[29,30,31,32,33],"Tranexamic Acid","Urethroplasty","Blood Loss","Hemoglobin","Reconstructive Urology","NOT_YET_RECRUITING","2026-03-25",{"date":37,"type":38},"2026-03-30","ACTUAL",{"date":40,"type":20},"2026-05-01",{"date":42,"type":20},"2027-03-30",{"name":44,"class":45},"Amjad Alwaal, MD, MSc, FRCSC, FACS","OTHER",""]