[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Andre Russowsky Brunoni\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":38},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":10,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":27,"lastUpdatePostDateStruct":28,"startDateStruct":31,"completionDateStruct":33,"leadSponsor":35,"locationsCount":5},"100641092",false,"NCT07657234","tDCS for Late-Life Depression","High-Dose Spaced Bilateral tDCS for Late-Life Depression: Open-Label Pilot Study","Inclusion Criteria:\n\nParticipants must meet all of the following criteria:\n\n1. age 60 years or older;\n2. diagnosis of unipolar major depressive disorder according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), confirmed by the Mini International Neuropsychiatric Interview (MINI);\n3. score of 17 or higher on the 17-item Hamilton Depression Rating Scale (HDRS-17) at screening;\n4. stable antidepressant regimen for at least four weeks prior to enrollment, if applicable;\n5. capacity to provide informed consent;\n6. Clinical Dementia Rating scale of 0 or 0.5.\n\nExclusion Criteria:\n\nParticipants meeting any of the following criteria will be excluded:\n\n1. contraindications to tDCS including metallic cranial implants, skin conditions at electrode sites (eczema, open wounds, burns, lesions), or history of adverse reaction to tDCS;\n2. contraindications to magnetic resonance imaging (MRI) including pacemaker, cochlear implants, ferromagnetic implants, or claustrophobia;\n3. history of seizures or epilepsy;\n4. bipolar disorder, psychotic disorders, or severe personality disorder;\n5. dementia or MoCA score below 17;\n6. substance use disorder within the past six months;\n7. neuromodulation treatment including electroconvulsive therapy (ECT), transcranial magnetic stimulation (TMS), tDCS, or vagus nerve stimulation (VNS) within the past six months;\n8. active suicidal ideation with plan or intent requiring a higher level of care;\n9. concurrent use of medications that substantially lower seizure threshold;\n10. pregnancy.","ALL","60 Years",{"count":18,"type":19},20,"ESTIMATED","INTERVENTIONAL",[22],"NA","The purpose of this research study is to determine the effectiveness of Transcranial direct current stimulation (tDCS) therapy in the treatment of participants with Late-life depression (LLD).\n\nThe study will evaluate feasibility, safety, and tolerability of high-dose (6mA) bilateral tDCS delivered as three daily sessions, 3 times a week, for 3 weeks in older adults (60 y\u002Fo and older) with late-life depression.",[25],"Late Life Depression (LLD)","NOT_YET_RECRUITING","2026-06-12",{"date":29,"type":30},"2026-06-18","ACTUAL",{"date":32,"type":19},"2026-08",{"date":34,"type":19},"2027-09",{"name":36,"class":37},"Andre Russowsky Brunoni","OTHER",""]