[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Ankara University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":642},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,53,0,25,[9,41,79,105,134,164,189,218,244,265,289,308,332,354,369,395,421,443,467,496,522,542,565,589,615],{"id":10,"slug":4,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":36,"leadSponsor":38,"locationsCount":4},"100644821",false,"NCT07673588","Instagram and Podcast Intervention for Breast Cancer Awareness and Screening","The Effect of an Instagram- and Podcast-Based Intervention on Women's Breast Cancer Awareness, Health Beliefs, and Screening Behaviors: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Women aged 20-39 years\n* Able to read and write Turkish\n* Turkish citizens\n* Have an active Instagram account and access it at least once daily\n* No previous diagnosis of cancer\n* Willing to participate and provide informed consent\n\nExclusion Criteria:\n\n* No access to a smartphone with the Instagram application\n* Visual, hearing, or cognitive impairment that may prevent participation in the intervention\n\nWithdrawal Criteria:\n\n* Failure to complete the assigned podcast sessions during the intervention period\n* Participant request to withdraw from the study at any time",true,"FEMALE","20 Years","39 Years",{"count":21,"type":22},180,"ESTIMATED","INTERVENTIONAL",[25],"NA","Breast cancer is the most common cancer among women worldwide. This randomized controlled trial aims to evaluate the effect of an Instagram- and podcast-based intervention on women's breast cancer awareness, health beliefs, and breast cancer screening behaviors among women aged 20-39 years.",[28,29],"Breast Cancer","Breast Cancer Screening","NOT_YET_RECRUITING","2026-07-01",{"date":33,"type":34},"2026-07-02","ACTUAL",{"date":31,"type":22},{"date":37,"type":22},"2026-12-01",{"name":39,"class":40},"Ankara University","OTHER",{"id":42,"slug":4,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":46,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":48,"minAge":49,"maxAge":4,"enrollmentInfo":50,"targetDuration":4,"studyType":23,"phases":52,"briefSummary":53,"conditions":54,"keywords":60,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":78},"100644334","NCT07662642","Timing of Recruitment Maneuver in Robotic Prostate Surgery","Comparison of the Effects of Recruitment Maneuver Timing on Postoperative Pulmonary Complications in Patients Undergoing Robotic Prostate Surgery","ROBPROREC1","Inclusion Criteria:\n\n* Patients scheduled for elective robotic prostate surgery\n* Age 18 years or older\n* Body mass index between 18 and 35 kg\u002Fm²\n* No cognitive impairment\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Age younger than 18 years\n* Emergency surgery\n* Preoperative oxygen requirement\n* Cognitive impairment\n* Refusal to participate in the study","MALE","18 Years",{"count":51,"type":22},86,[25],"Robotic prostate surgery is commonly performed under general anesthesia with carbon dioxide pneumoperitoneum and steep Trendelenburg positioning. These conditions may reduce lung volumes, impair respiratory mechanics, and increase the risk of atelectasis and postoperative pulmonary complications. Recruitment maneuvers combined with individualized positive end-expiratory pressure may improve intraoperative oxygenation and lung compliance; however, the optimal timing of recruitment maneuver application in robotic prostate surgery remains unclear.\n\nThis prospective randomized study aims to compare the effects of recruitment maneuver timing on postoperative pulmonary complications in adult patients undergoing elective robotic prostate surgery. Participants will be randomized into two groups. In the Supine Recruitment Group, the recruitment maneuver will be performed before carbon dioxide insufflation while the patient is in the supine position, followed by individualized PEEP determination. In the Trendelenburg Recruitment Group, the recruitment maneuver will be performed after pneumoperitoneum and Trendelenburg positioning, followed by individualized PEEP determination. Patients will be evaluated for postoperative pulmonary complications up to postoperative 72 hours or until discharge, whichever occurs first.",[55,56,57,58,59],"Robotic Surgery","Urologic Surgical Procedures","Postoperative Pulmonary Complications (PPCs)","Pulmonary Atelectasis","Postoperative Complications",[61,62,63,64,65,66,67,68],"Robotic prostate surgery","Recruitment maneuver","Pneumoperitoneum","Trendelenburg position","Positive end-expiratory pressure","Atelectasis","Postoperative pulmonary complications","General anesthesia","RECRUITING","2026-06-16",{"date":72,"type":34},"2026-06-23",{"date":74,"type":34},"2026-05-09",{"date":76,"type":22},"2026-07-20",{"name":39,"class":40},1,{"id":80,"slug":4,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":84,"eligibilityCriteria":85,"healthyVolunteers":11,"sex":48,"minAge":49,"maxAge":4,"enrollmentInfo":86,"targetDuration":4,"studyType":23,"phases":88,"briefSummary":90,"conditions":91,"keywords":93,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":101,"leadSponsor":103,"locationsCount":104},"100626915","NCT07441837","Terbium 161 PSMA in Lutetium-177 PSMA Naive Patients","Phase 2 Study of Terbium 161 PSMA in Lutetium-177 PSMA Naive mCRPC Patients","TeLuNa","Inclusion Criteria:\n\n* Men aged 18 years or older with mCRPC (histologically or cytologically confirmed adenocarcinoma of the prostate)\n* Progressive disease as defined by the Prostate Cancer Clinical Trials Working Group 3 (PCWG3) under previous treatment with taxane chemotherapy (unless medically unsuitable) and at least one second-generation androgen receptor pathway inhibitor (ARPI)\n* Adequate bone marrow, hepatic, and renal function\n* Eastern Cooperative Oncology Group performance status of 0-2;\n* A life expectancy of at least 6 months.\n* On Ga-68 PSMA PET\u002FCT, a maximum standardised uptake value (SUVmax) of at least 20 in at least one metastasis and SUVmax of at least 10 in measurable soft tissue metastases.\n* Patient has provided written informed consent\n* PSA progression: minimum of 2 rising PSA values from baseline measurement with interval of ≥1 wk between each measurement\n* Soft-tissue progression: per RECIST 1.1\n* Bone progression: ≥2 new lesions on bone scan\n* At least 3 wk interval since completion of surgery or radiotherapy before registration\n\nExclusion Criteria:\n\n* Patients with discordant metastases defined as positive on 2-\\[¹⁸F\\]fluoro-2-deoxy-D-glucose (FDG) PET-CT with minimal uptake on Ga-68-PSMA PET-CT\n* Previous treatment with another radioisotope\n* Other malignancies within the previous 2 years before registration other than basal cell or squamous cell carcinomas of skin or other cancers that are unlikely to recur within 24 months\n* Concurrent illnesses that could jeopardise the ability of the patient to undergo the trial procedures.\n* Patient has symptomatic brain metastases or leptomeningeal metastases\n* Patient has symptomatic or impending cord compression unless appropriately treated beforehand and clinically stable for \\>4 wk",{"count":87,"type":22},60,[89],"PHASE2","In this study it is aimed to analyze the efficacy and safety of Tb-161 PSMA I\\&T in the 7.4 GBq activity in a large patient group of Lu-177 PSMA naïve mCRPC patients. 3 cycles of Tb-161 PSMA will be administered with 6 weeks periods. After each cycle a triple bed quantitative single photon emission CT (SPECT)-CT scan from vertex to thigh will be acquired 24 h after every treatment of Tb-161 PSMA. In the first cycle additional time points SPECT-CT acquisitions will be obtained for dosimetric calculations. Details of dosimetry acquisitions will be provided by dosimetry partner. Routine safety blood tests including full blood counts, liver function test, electrolytes, serum PSA, and assessment for adverse events were performed every 3 weeks during study treatment. Once the patient completed three cycles of Tb-161 PSMA, they will continue to undergo clinical review, assessment for adverse events, routine safety bloods, and PSA every 6 weeks for 48 weeks. OR to treatment will be assessed by Ga-68 PSMA PET\u002FCT using RECIP 1.0 criteria.",[92],"Prostate Cancer",[94,95,96],"Prostate cancer","terbium-166","radionuclide treatment","2026-06-08",{"date":99,"type":34},"2026-06-10",{"date":31,"type":22},{"date":102,"type":22},"2028-09-01",{"name":39,"class":40},4,{"id":106,"slug":4,"hasResults":11,"nctId":107,"briefTitle":108,"officialTitle":109,"acronym":4,"eligibilityCriteria":110,"healthyVolunteers":11,"sex":111,"minAge":112,"maxAge":113,"enrollmentInfo":114,"targetDuration":4,"studyType":23,"phases":116,"briefSummary":117,"conditions":118,"keywords":120,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":126,"lastUpdatePostDateStruct":127,"startDateStruct":129,"completionDateStruct":131,"leadSponsor":133,"locationsCount":78},"100634196","NCT07536542","Effects of Dual-Task Training on Upper Extremity Function in Parkinson's Disease","Effects of Dual-Task Training on Upper Extremity Function and Muscle Thickness in Parkinson's Disease","Inclusion Criteria:\n\n* Diagnosis of idiopathic Parkinson's disease confirmed by a neurologist\n* Modified Hoehn and Yahr stage 2 to 3\n* No medication or dosage change within the last 6 months\n* Cognitive capacity sufficient to understand and follow instructions, defined as Montreal Cognitive Assessment score ≥21\n* Voluntary participation with written informed consent\n\nExclusion Criteria:\n\n* Atypical or secondary parkinsonism\n* Advanced orthopedic condition affecting the upper extremity\n* Surgery, trauma, or immobilization involving the upper extremity within the last 6 months\n* Wound or dermatological condition preventing upper extremity ultrasonographic evaluation\n* Severe visual or hearing loss\n* Severe depression, psychosis, or communication difficulty\n* Any additional health problem preventing regular participation in the study","ALL","40 Years","65 Years",{"count":115,"type":22},38,[25],"The goal of this clinical trial is to investigate the effects of dual-task training on upper extremity function and muscle thickness in individuals with Parkinson's disease. The main questions it aims to answer are:\n\nDoes dual-task training improve upper extremity function in individuals with Parkinson's disease? Does dual-task training lead to changes in upper extremity muscle thickness measured by ultrasonography?\n\nResearchers will compare a dual-task training group with a control group receiving routine care to determine whether 8 weeks of dual-task training results in greater improvements in upper extremity outco\n\nParticipants will:\n\ncomplete baseline and post-intervention assessments of upper extremity function, muscle thickness, grip strength, and pinch strength be assigned to either a control group or a dual-task training group receive dual-task training 3 days per week for 8 weeks if assigned to the intervention group",[119],"Parkinson Disease (PD)",[121,122,123,124,125],"Parkinson Disease","Dual-Task Training","Upper Extremity Function","Muscle Thickness","Ultrasonography","2026-05-31",{"date":128,"type":34},"2026-06-02",{"date":130,"type":34},"2026-04-24",{"date":132,"type":22},"2026-08-01",{"name":39,"class":40},{"id":135,"slug":4,"hasResults":11,"nctId":136,"briefTitle":137,"officialTitle":137,"acronym":4,"eligibilityCriteria":138,"healthyVolunteers":11,"sex":111,"minAge":49,"maxAge":4,"enrollmentInfo":139,"targetDuration":4,"studyType":23,"phases":141,"briefSummary":142,"conditions":143,"keywords":149,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":156,"lastUpdatePostDateStruct":157,"startDateStruct":159,"completionDateStruct":161,"leadSponsor":163,"locationsCount":104},"100637389","NCT07619209","The Effect of Progressive Muscle Relaxation and Deep Breathing Exercises Applied to Palliative Care Cancer Patients on Dyspnea, Fatigue, and Self-Care Behaviors","Inclusion Criteria:\n\n* Being 18 years of age or older\n\nBeing literate (able to read and write)\n\nHaving no significant hearing or visual impairment that prevents communication or cooperation\n\nReceiving treatment in the palliative care unit\n\nHaving a confirmed medical diagnosis of cancer\n\nHaving a Glasgow Coma Scale (GCS) score of 10 or higher\n\nBeing able to communicate via telephone and SMS for post-discharge follow-up\n\nHaving a Common Terminology Criteria for Adverse Events (CTCAE) Dyspnea Classification of Grade 3 or below\n\nHaving an ECOG Performance Status Scale score of 3 or below\n\nHaving a Hemoglobin (Hb) value of 8 gm\u002FdL or higher\n\nVolunteering to participate in the study and providing informed consent\n\nExclusion Criteria:\n\n* Currently practicing or having recently practiced Progressive Muscle Relaxation (PMR) or deep breathing exercises actively\n\nHaving a primary respiratory system disease diagnosis (such as COPD, asthma, or pneumonia)\n\nHaving a medical diagnosis of dementia, agitation, or delirium\n\nReceiving Continuous Positive Airway Pressure (CPAP) or Bilevel Positive Airway Pressure (BiPAP) support\n\nBeing on active antipsychotic or sedative medical treatment\n\nHaving a Common Terminology Criteria for Adverse Events (CTCAE) Dyspnea Classification of Grade 4 or higher",{"count":140,"type":22},90,[25],"The purpose of this study is to evaluate the effects of Progressive Muscle Relaxation (PMR) exercises and deep breathing exercises on dyspnea, fatigue, and self-care behaviors among cancer patients receiving palliative care. Advanced-stage cancer patients frequently experience debilitating symptoms such as shortness of breath (dyspnea) and severe fatigue, which significantly impair their functional capacity and daily self-care activities. Participants in this study will be assigned to either a progressive muscle relaxation intervention group or a structured deep breathing exercise group. The study aims to determine whether these non-pharmacological relaxation techniques can effectively reduce the severity of dyspnea and fatigue, thereby improving the patients' overall self-care behaviors and physical comfort in a palliative care setting.",[144,145,146,147,148],"Cancer","Fatigue","Palliative Care","Progressive Muscle Relaxation","Patient",[146,150,147,151,152,153,154,155],"Cancer Patients","Deep Breathing Exercises","Dyspnea Management","Cancer-Related Fatigue","Self-Care Behaviors","Randomized Controlled Trial","2026-05-30",{"date":158,"type":34},"2026-06-03",{"date":160,"type":34},"2026-01-01",{"date":162,"type":22},"2026-12",{"name":39,"class":40},{"id":165,"slug":4,"hasResults":11,"nctId":166,"briefTitle":167,"officialTitle":168,"acronym":4,"eligibilityCriteria":169,"healthyVolunteers":16,"sex":111,"minAge":4,"maxAge":170,"enrollmentInfo":171,"targetDuration":4,"studyType":23,"phases":173,"briefSummary":174,"conditions":175,"keywords":177,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":181,"lastUpdatePostDateStruct":182,"startDateStruct":184,"completionDateStruct":186,"leadSponsor":188,"locationsCount":4},"100638820","NCT07603843","Use of Cognitive Aid Methods in the Management of Status Epilepticus","İmpact of Cognitive Aid Methods on Clinical Decision-making in the Management of Status Epilepticus in the Emergency Department: A Simulation-based Study","Inclusion Criteria:\n\n* Being a sixth-year Emergency Medicine intern\n* Willingness to participate in the study\n\nExclusion Criteria:\n\n* Previous participation in simulation studies involving cognitive aids,\n* Prior involvement in the development of the cognitive aids used in this study","80 Years",{"count":172,"type":22},76,[25],"This study aims to evaluate whether cognitive aids improve the management performance of sixth-year Emergency Medicine interns during simulated status epilepticus scenarios. It will also examine whether the format of the cognitive aid (paper-based or digital) influences technical and non-technical performance during crisis management.\n\nThe main questions it aims to answer are:\n\nDo cognitive aids improve adherence to evidence-based status epilepticus management during simulation? Do cognitive aids reduce time to initiation of critical treatments? Is there a difference between paper-based and digital cognitive aids in terms of performance, cognitive workload, and stress levels?\n\nResearchers will compare paper-based cognitive aids, digital cognitive aids, and standard management without cognitive aids in standardized simulation scenarios.\n\nParticipants will:\n\nAttend a standardized didactic session on status epilepticus management Participate in a high-fidelity simulation scenario approximately one month after the educational session Use either a paper-based cognitive aid, a digital cognitive aid, or no cognitive aid during the simulation scenario Complete post-simulation assessments evaluating stress levels, cognitive workload, and participant satisfaction Participate in structured debriefing sessions following the simulation exercise\n\nStudy Groups Intervention Group A\n\nA cognitive aid (status epilepticus management checklist\u002Falgorithm in paper format) will be provided during the simulated scenario.\n\nIntervention Group B\n\nA cognitive aid (status epilepticus management checklist\u002Falgorithm in digital format) will be provided during the simulated scenario.\n\nControl Group\n\nNo cognitive aid will be provided. Participants will manage the patient using only their existing knowledge and clinical reasoning skills.\n\nStudy Procedure\n\n1. Pre-Simulation Preparation All participants will receive a standardized didactic lecture on status epilepticus management delivered by a faculty member from the Department of Emergency Medicine.\n\n   A validated cognitive aid for status epilepticus management (checklist\u002Falgorithm\u002Fflowchart) will be developed in accordance with current evidence-based guidelines.\n\n   One month after the didactic session, all participants will participate in a simulation scenario focused on status epilepticus management.\n2. Simulation Scenarios Participants will manage standardized status epilepticus scenarios requiring timely and appropriate interventions, including: benzodiazepine administration, escalation to second-line therapy, glucose assessment and correction, airway management when indicated.\n\nScenario-specific performance assessment checklists will be developed to evaluate technical skills.\n\nNon-technical skills will be assessed using the Ottawa Global Rating Scale.\n\nOutcomes Primary Outcomes Technical performance in status epilepticus management Non-technical performance during crisis management Time to initiation of first-line treatment (e.g., benzodiazepine administration) Time to initiation of second-line treatment Secondary Outcomes Adherence to evidence-based guidelines (appropriate medication selection, dosage, and timing) Completion of essential management steps (e.g., glucose control, airway management) Team communication and coordination (assessed using the Ottawa Global Rating Scale) Participant stress levels measured using the State-Trait Anxiety Inventory (STAI)\n\nPost-Simulation Assessment Structured debriefing sessions will be conducted following the simulation scenarios.\n\nParticipants will complete assessments evaluating: cognitive workload (using the NASA Task Load Index), satisfaction with the cognitive aid (intervention groups only).\n\nEthical Considerations Written informed consent will be obtained from all participants. The anonymity and confidentiality of simulation recordings will be ensured. Participants will be informed that study participation will not affect their Emergency Medicine internship evaluation in any way.",[176],"Last Year Medical Student",[178,179,180],"cognitive aids","status epilepticus","simulation","2026-05-27",{"date":183,"type":34},"2026-05-29",{"date":185,"type":22},"2026-05-25",{"date":187,"type":22},"2026-07-10",{"name":39,"class":40},{"id":190,"slug":4,"hasResults":11,"nctId":191,"briefTitle":192,"officialTitle":193,"acronym":4,"eligibilityCriteria":194,"healthyVolunteers":11,"sex":111,"minAge":49,"maxAge":4,"enrollmentInfo":195,"targetDuration":4,"studyType":23,"phases":197,"briefSummary":198,"conditions":199,"keywords":204,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":210,"lastUpdatePostDateStruct":211,"startDateStruct":213,"completionDateStruct":215,"leadSponsor":217,"locationsCount":78},"100633576","NCT07528482","Effects of Reflexology and Cold Application Before Chest Tube Removal in CABG Patients","Determining the Effects of Reflexology and Cold Application Before Chest Tube Removal on Pain, Anxiety, and Physiological Parameters in Patients Undergoing Coronary Artery Bypass Grafting: A Randomized Controlled Study","Inclusion Criteria:\n\n* Being 18 years of age or older\n* Not having undergone previous open heart surgery\n* Not having received analgesics within 4 hours prior to the procedure\n* Having a VAS pain score of 3 or higher\n* Voluntary participation in the study\n\nExclusion Criteria:\n\n* Being under 18 years of age\n* Using inotropic drugs\n* Having a history of chronic pain\n* Having a history of alcohol or drug use\n* Having a psychiatric illness\n* Having skin lesions, burns, or wounds on the feet that would prevent massage application",{"count":196,"type":22},108,[25],"This study aims to evaluate the effects of combined reflexology and cold application on pain, anxiety, and physiological parameters in patients undergoing chest tube removal (CTR) after coronary artery bypass grafting (CABG) surgery. Chest tube removal is an invasive procedure that often causes significant pain and anxiety, which can negatively impact the recovery process. In this randomized controlled trial, patients will be assigned to a combined intervention group (reflexology and cold application) or a control group. The study seeks to provide evidence-based recommendations for non-pharmacological nursing interventions to improve patient comfort and reduce complications during the post-operative period.",[200,201,202,203],"Pain, Acute Post-Operative","Anxiety","Chest Tube Removal","Coronary Artery Bypass",[205,206,207,208,209],"Reflexology","Cold Application","Chest Tube Removal Pain","Non-pharmacological Interventions","Nursing Care","2026-04-10",{"date":212,"type":34},"2026-04-14",{"date":214,"type":34},"2025-12-15",{"date":216,"type":22},"2026-05-04",{"name":39,"class":40},{"id":219,"slug":4,"hasResults":11,"nctId":220,"briefTitle":221,"officialTitle":222,"acronym":4,"eligibilityCriteria":223,"healthyVolunteers":11,"sex":111,"minAge":49,"maxAge":4,"enrollmentInfo":224,"targetDuration":4,"studyType":23,"phases":226,"briefSummary":227,"conditions":228,"keywords":233,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":236,"lastUpdatePostDateStruct":237,"startDateStruct":239,"completionDateStruct":241,"leadSponsor":243,"locationsCount":78},"100632764","NCT07517926","Chewing Gum and Cold Gargle on Post-Bronchoscopy Symptoms","The Effect of Chewing Gum and Gargling With Cold Water on Post-Bronchoscopy Sore Throat, Dysphagia, and Patient Satisfaction: A Randomized Controlled Study","Inclusion Criteria:\n\n* • Being 18 years of age or older\n\n  * Having a scheduled diagnostic bronchoscopy\n  * Having normal speech and swallowing functions\n  * Being conscious and able to communicate\n  * Volunteering to participate in the study\n\nExclusion Criteria:\n\n* • Complications during bronchoscopy\n\n  * Gastroesophageal reflux\n  * Use of non-steroidal anti-inflammatory drugs\n  * Receiving steroid treatment within 1 week prior to the procedure\n  * Active infection or disease in the mouth or throat area\n  * History of allergy or intolerance to the procedure\n  * Previous anatomical or functional impediment to chewing gum or gargling",{"count":225,"type":22},100,[25],"This study aims to evaluate the effects of chewing gum and gargling with cold water on common post-bronchoscopy symptoms, such as sore throat and difficulty swallowing (dysphagia). Bronchoscopy is a procedure that can cause temporary throat discomfort. In this randomized controlled trial, patients will be divided into groups to receive either chewing gum, cold water gargle, or standard care. The researchers will then measure and compare patient satisfaction levels and the severity of throat symptoms to determine if these simple interventions can improve patient comfort after the procedure.",[229,230,231,232],"Sore Throat","Dysphagia","Patient Satisfaction","Bronchoscopy",[232,229,230,234,235,209],"Chewing Gum","Cold Water Gargle","2026-04-07",{"date":238,"type":34},"2026-04-13",{"date":240,"type":34},"2025-11-10",{"date":242,"type":22},"2026-05-11",{"name":39,"class":40},{"id":245,"slug":4,"hasResults":11,"nctId":246,"briefTitle":247,"officialTitle":248,"acronym":4,"eligibilityCriteria":249,"healthyVolunteers":11,"sex":17,"minAge":49,"maxAge":250,"enrollmentInfo":251,"targetDuration":4,"studyType":23,"phases":253,"briefSummary":254,"conditions":255,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":257,"lastUpdatePostDateStruct":258,"startDateStruct":260,"completionDateStruct":262,"leadSponsor":264,"locationsCount":4},"100632934","NCT07520136","Evaluation of the Effect of a Structured Yoga Exercise in Young Women With Primary Dysmenorrhea","Evaluation of the Effect of a Structured Yoga Exercise Program on Pain, Menstrual Symptoms, and Quality of Life in Young Women With Primary Dysmenorrhea","Inclusion Criteria:\n\n* Healthy young women with primary dysmenorrhea\n* Aged between 18-25 years\n* Having a regular menstrual cycle (30-35 days)\n* Menstrual bleeding duration of 3-10 days\n\nExclusion Criteria:\n\n* Having secondary dysmenorrhea\n* Participation in regular physical activity or other exercise programs\n* Use of medication\n* Diagnosed with polycystic ovary syndrome\n* Having bleeding disorders\n* Positive pregnancy test\n* Being in the breastfeeding period\n* Primary dysmenorrhea attributed to medical disorders or other causes\n* Participants who miss three consecutive sessions or four alternating sessions during the study will be excluded from the research","25 Years",{"count":252,"type":22},30,[25],"Abstract\n\nPrimary dysmenorrhea is a common gynecological condition affecting women of reproductive age and negatively impacting quality of life. It is characterized by cramping pain in the lower abdomen that may radiate to the lower back and thighs, leading to decreased daily functioning, academic performance, and psychological well-being. In addition to pharmacological treatments, complementary approaches are increasingly used in the management of dysmenorrhea. Yoga, a mind-body exercise that combines physical movement with mental focus, has been suggested as an effective method for reducing stress and pain associated with dysmenorrhea.\n\nThe aim of this study is to evaluate the level of awareness about dysmenorrhea in young women with primary dysmenorrhea and to investigate the effects of a yoga program on pain, quality of life, and menstrual attitudes following an educational session provided to all participants. Pain severity, quality of life, and menstrual attitudes will be assessed using validated questionnaires and scales, including the Visual Analog Scale (VAS), awareness questionnaire, functional and emotional dysmenorrhea scale, Menstrual Attitude Scale, and quality of life questionnaire.\n\nThis study aims to determine whether yoga exercises reduce dysmenorrhea symptoms and improve quality of life in young women with primary dysmenorrhea. Additionally, the study is expected to increase awareness about dysmenorrhea and provide evidence for the effectiveness of yoga as a non-pharmacological intervention.",[256],"Primary Dysmenorrhea","2026-04-02",{"date":259,"type":34},"2026-04-09",{"date":261,"type":22},"2026-04",{"date":263,"type":22},"2026-11",{"name":39,"class":40},{"id":266,"slug":4,"hasResults":11,"nctId":267,"briefTitle":268,"officialTitle":269,"acronym":4,"eligibilityCriteria":270,"healthyVolunteers":11,"sex":111,"minAge":271,"maxAge":272,"enrollmentInfo":273,"targetDuration":4,"studyType":23,"phases":275,"briefSummary":276,"conditions":277,"keywords":279,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":257,"lastUpdatePostDateStruct":284,"startDateStruct":285,"completionDateStruct":287,"leadSponsor":288,"locationsCount":4},"100632406","NCT07513272","EFFECT OF BALLS ON PAIN AND ANXIETY DURING VENIPUNCTURE IN CHILDREN","THE EFFECT OF TWO DIFFERENT BALLS USED DURING VENIPUNCTURE IN CHILDREN ON PAIN AND ANXIETY LEVELS: A RANDOMIZED CONTROLLED STUDY","Inclusion Criteria:\n\nChildren aged 7-12 years. At least one prior experience of blood draw within the past year. Able to communicate in Turkish. Written informed consent obtained from both child and parents. No physical, auditory, intellectual, or neurological disabilities. No dermatological conditions affecting hand integrity. No analgesic, antipyretic, or anti-inflammatory drug use within the last 12 hours.\n\nNo acute pain reported before the procedure. No chronic illness causing regular invasive procedures or chronic pain.\n\nExclusion Criteria:\n\nInability to complete the first blood draw. Holding another object during the procedure. Withdrawal from the study at any point. Not meeting any of the inclusion criteria listed above.","7 Years","12 Years",{"count":274,"type":22},144,[25],"The goal of this clinical trial is to evaluate whether using two different types of balls can reduce pain and anxiety during venipuncture in school-aged children (7-12 years) in a pediatric emergency setting. The main questions it aims to answer are:\n\nDoes squeezing a soft ball or a textured (ridged) ball during venipuncture reduce perceived pain compared to a control group? Does squeezing a soft ball or a textured (ridged) ball during venipuncture reduce situational anxiety compared to a control group?\n\nResearchers will compare the soft ball, textured ball, and control groups to see if the type of ball affects children's pain and anxiety levels.\n\nParticipants will:\n\nComplete a demographic and clinical information form. Use Wong-Baker Faces Pain Rating Scale (WBS) and Child Anxiety Scale-State (ÇAS-D) to report pain and anxiety before, during, and after venipuncture.\n\nSqueeze either a soft or textured ball during venipuncture (for experimental groups) while control group children receive standard care without distraction.",[278],"Venipuncture-related Pain and Anxiety",[280,281,282,283],"pain","child","venipuncture","anxiety",{"date":236,"type":34},{"date":286,"type":22},"2026-05-01",{"date":37,"type":22},{"name":39,"class":40},{"id":290,"slug":4,"hasResults":11,"nctId":291,"briefTitle":292,"officialTitle":293,"acronym":294,"eligibilityCriteria":295,"healthyVolunteers":16,"sex":111,"minAge":49,"maxAge":4,"enrollmentInfo":296,"targetDuration":4,"studyType":23,"phases":297,"briefSummary":298,"conditions":299,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":301,"lastUpdatePostDateStruct":302,"startDateStruct":303,"completionDateStruct":305,"leadSponsor":307,"locationsCount":4},"100632007","NCT07508085","Low-Dose, High-Frequency CPR Training in Pediatric Emergency Nurses","Effect of Low-Dose, High-Frequency Cardiopulmonary Resuscitation Training on Knowledge and Skill Levels in Pediatric Emergency Nurses: A Randomized Controlled Trial","LDHF CPR Peds","Inclusion Criteria:\n\nNurses actively working in the pediatric emergency department of Ankara Etlik City Hospital Nurses who are scheduled to be on duty during the data collection period Nurses who agree to participate in the study Nurses who provide written informed consent\n\nExclusion Criteria:\n\nNurses who have received structured low-dose, high-frequency CPR training within the last 6 months Nurses who are unable to attend training or assessment sessions due to planned leave, illness, or other unforeseen circumstances Nurses who do not participate in any stage of the training program or fail to complete the data collection process",{"count":87,"type":22},[25],"Life-threatening conditions such as respiratory failure, shock, and cardiac arrest require rapid recognition and timely intervention in pediatric emergency settings. Pediatric emergency nurses play a critical role in initiating and supporting cardiopulmonary resuscitation (CPR). However, the low frequency of CPR events may limit skill practice and lead to a decline in knowledge and performance over time.\n\nLow-dose, high-frequency (LDHF) training, which involves brief and repeated practice sessions, has been proposed as an effective approach to improve skill retention.\n\nThis study aims to evaluate the effect of LDHF CPR training on the knowledge and skill levels of pediatric emergency nurses and to compare its effectiveness with the massed training (MT) model.",[300],"Low-Dose High-Frequency CPR Training","2026-03-27",{"date":257,"type":34},{"date":304,"type":22},"2026-04-01",{"date":306,"type":22},"2026-09-01",{"name":39,"class":40},{"id":309,"slug":4,"hasResults":11,"nctId":310,"briefTitle":311,"officialTitle":311,"acronym":4,"eligibilityCriteria":312,"healthyVolunteers":11,"sex":111,"minAge":49,"maxAge":113,"enrollmentInfo":313,"targetDuration":4,"studyType":23,"phases":314,"briefSummary":315,"conditions":316,"keywords":321,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":325,"lastUpdatePostDateStruct":326,"startDateStruct":327,"completionDateStruct":328,"leadSponsor":330,"locationsCount":331},"100623442","NCT07396688","Comparative Evaluation of the Effects of Calcium Hydroxide and BIO-C Temp Medicaments on Postoperative Pain in Patients Undergoing Endodontic Treatment: a Clinical Study","Inclusion Criteria:\n\n* • Patients with single-rooted teeth requiring endodontic retreatment.\n\n  * Individuals in good general health, classified as ASA Physical Status I.\n  * Teeth presenting normal anatomical structure and root morphology.\n\nExclusion Criteria:\n\n* • Patients who have used antibiotics or analgesic medications within the last month.\n\n  * Pregnant individuals and patients with systemic diseases (such as chronic illnesses, diabetes mellitus, hypertension).\n  * Teeth with root fractures or perforations.\n  * Teeth with complex root canal anatomy, multirooted teeth, or severely curved roots.\n  * Patients presenting with high baseline pain levels, particularly those with a history of treatment-resistant pain.",{"count":87,"type":22},[25],"This clinical study is designed to evaluate postoperative pain experienced by patients undergoing multi-visit endodontic retreatment and to investigate whether the choice of intracanal medicament influences pain levels between treatment sessions. Postoperative pain is a common concern following root canal procedures and may negatively affect patient comfort, treatment satisfaction, and overall perception of dental care.\n\nCalcium hydroxide has long been used as a conventional intracanal medicament in endodontic therapy due to its antimicrobial properties. In recent years, bioceramic-based materials such as Bio-C Temp have been introduced as alternative intracanal medicaments, with proposed advantages related to biocompatibility and interaction with dental tissues. However, limited clinical evidence is available regarding their effect on postoperative pain when compared with conventional materials.\n\nIn this study, patients requiring multi-visit endodontic retreatment will receive either calcium hydroxide or Bio-C Temp as an intracanal medicament between treatment sessions. Pain intensity will be evaluated at specific time points following treatment using standardized pain assessment scales. In addition to pain intensity, the use of analgesic medication will also be recorded.\n\nThe primary objective of this study is to compare interappointment postoperative pain levels associated with calcium hydroxide and Bio-C Temp. Secondary objectives include evaluating analgesic consumption. By comparing a conventional intracanal medicament with a newer bioceramic-based alternative, this study aims to contribute to a better understanding of how intracanal medicament selection may influence postoperative pain and patient experience during endodontic retreatment.\n\nThe findings of this study may help clinicians make more informed decisions regarding intracanal medicament selection and improve pain management strategies in endodontic practice.",[317,318,319,320],"Postoperative Pain","Medicaments Substances in Therapeutic Use","Calcium Hydroxide","Root Canal Retreatment",[322,317,323,324,319],"Visual Analog Scale","Bioceramic Intracanal Medicament","Endodontic Retreatment","2026-03-25",{"date":301,"type":34},{"date":325,"type":22},{"date":329,"type":22},"2026-04-15",{"name":39,"class":40},2,{"id":333,"slug":4,"hasResults":11,"nctId":334,"briefTitle":335,"officialTitle":336,"acronym":4,"eligibilityCriteria":337,"healthyVolunteers":16,"sex":111,"minAge":112,"maxAge":338,"enrollmentInfo":339,"targetDuration":341,"studyType":342,"phases":4,"briefSummary":343,"conditions":344,"keywords":4,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":346,"lastUpdatePostDateStruct":347,"startDateStruct":349,"completionDateStruct":351,"leadSponsor":353,"locationsCount":78},"100601192","NCT07107295","Thoracolumbar Fascia Thickness in Chronic Stroke Patients","Investigation of Thoracolumbar Fascia Thickness and Its Relationship With Balance, Trunk Control, Trunk Flexibility, and Functional Independence in Chronic Stroke Patients","Inclusion Criteria:\n\n* Being between 40 and 70 years old.\n* Being diagnosed with a stroke by a neurologist.\n* Scoring above 21 on the Montreal Cognitive Assessment Scale.\n* Scoring between 0 and 3 on the Modified Rankin Scale.\n* Being at least 6 months past the stroke\n\nExclusion Criteria:\n\n* Inability to communicate verbally\n* Individuals with severe visual impairment, neurological disorders in addition to stroke, and\u002For congestive heart failure\n* Patients in whom exercise is not recommended.","70 Years",{"count":340,"type":22},70,"1 Day","OBSERVATIONAL","The main objective of this study was to examine the thoracolumbar fascia thickness in chronic stroke patients using objective methods and to reveal the relationship of this flexibility with balance, trunk control, trunk flexibility, functional independence and other relevant clinical parameters. Demographic information will be recorded and evaluated. Thoracolumbar fascia thickness will be assessed for individuals in both groups using ultrasonography, trunk flexibility using the Sit-and-Reach test, trunk function using the Trunk Impairment Scale, balance using the Functional Reach Test and the Timed Up and Go test, and functional independence using the Functional Independence Scale.",[345],"Stroke","2026-03-22",{"date":348,"type":34},"2026-03-24",{"date":350,"type":34},"2025-08-01",{"date":352,"type":22},"2026-05",{"name":39,"class":40},{"id":355,"slug":4,"hasResults":11,"nctId":356,"briefTitle":357,"officialTitle":358,"acronym":4,"eligibilityCriteria":359,"healthyVolunteers":16,"sex":111,"minAge":360,"maxAge":170,"enrollmentInfo":361,"targetDuration":4,"studyType":342,"phases":4,"briefSummary":362,"conditions":363,"keywords":4,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":346,"lastUpdatePostDateStruct":364,"startDateStruct":365,"completionDateStruct":367,"leadSponsor":368,"locationsCount":78},"100593772","NCT07010783","Respiratory Functions in Parkinson's Disease","Investigation of Respiratory Functions, Inspiratory Muscle Strength, Physical Fitness and Aerobic Capacity in Patients With Parkinson's Disease","Inclusion Criteria:\n\n* Age 50 to 80\n* Mini Mental State Examination score of 24 to 30\n* Diagnosed with Parkinson's Disease by a neurologist\n\nExclusion Criteria:\n\n* Sözlü iletişim kuramama\n* Yürüme yardımcısı kullanıma\n* Ciddi görme bozukluğu, ek nörolojik bozuklukları ve\u002Fveya konjestif kalp yetmezliği olan yaşlılar\n* Egzersiz yapılması tavsiye edilmeyen yaşlı yetişkinler.","50 Years",{"count":225,"type":22},"The aim is to examine respiratory functions, inspiratory muscle strength, respiratory function, physical fitness and aerobic capacity in Parkinson's disease patients. Individuals between the ages of 50-80 who have been diagnosed with Parkinson's disease by a neurologist and healthy individuals with similar demographic characteristics will be included in the study as a control group. In addition, patients will be divided into three groups as above and below 2.5 and healthy controls according to the Modified Hoehn and Yahr Scale. Demographic information of the individuals will be recorded and clinical evaluations will be made. The staging of Parkinson's patients will be done with the Modified Hoehn and Yahr Scale, and the severity of the disease will be done with the Unified Parkinson's Disease Rating Scale. The inspiratory muscle strength of the individuals will be evaluated with the PowerBreath K5, respiratory functions with the Pulmonary Function Test device, and physical fitness and aerobic capacity with the Senior Fitness Test.",[121],{"date":348,"type":34},{"date":366,"type":34},"2025-07-01",{"date":352,"type":22},{"name":39,"class":40},{"id":370,"slug":4,"hasResults":11,"nctId":371,"briefTitle":372,"officialTitle":373,"acronym":4,"eligibilityCriteria":374,"healthyVolunteers":16,"sex":111,"minAge":49,"maxAge":113,"enrollmentInfo":375,"targetDuration":4,"studyType":23,"phases":377,"briefSummary":378,"conditions":379,"keywords":382,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":389,"lastUpdatePostDateStruct":390,"startDateStruct":391,"completionDateStruct":392,"leadSponsor":394,"locationsCount":78},"100630806","NCT07492459","Effects of Motivational Interviewing Training on Nursing Students' Counselling Skills, Self-Efficacy, and Reluctance","The Effect of Motivational Interviewing-Based Communication Training on Nursing Students' Counseling Skills, Self-Efficacy, and Reluctance in Communication","Inclusion Criteria:\n\n* Being a second-year nursing student\n* Volunteering to participate in the research\n* Not having communication problems that would prevent answering data collection forms\n\nExclusion Criteria:\n\n* Having communication problems that would prevent answering data collection forms\n* Being a 1st, 3rd or 4th year nursing student",{"count":376,"type":22},72,[25],"This research is designed to determine the effect of motivational interview-based communication training on nursing students' counselling skills, communication self-efficacy, and communication reluctance levels. The project will be conducted using a randomised controlled experimental design. The sample will consist of 72 second-year nursing students studying at the Department of Nursing, Ankara University Faculty of Nursing. Participants will be randomly assigned to experimental (n=36) and control (n=36) groups. The experimental group will receive motivational interview-based communication training, while the control group will receive training on basic communication and interpersonal interaction skills in nursing. The training will consist of five sessions; theoretical sessions will be 60 minutes each, and the standard patient interview practice to be applied to the experimental group will last three days. The standard patient interview practices will be conducted in the Communication Skills Laboratory of Ankara University Faculty of Nursing. The research data will be collected using a Demographic Information Form, the Counselling Skills Scale for Nurses, the Effective Communication Self-Efficacy Inventory, and the Communication Reluctance Scale, through pre-test, post-test, and follow-up measurements. Additionally, the project plans to train individuals to assume the role of a standard patient in the communication skills laboratory, creating a standard patient pool that can be used in future training and research. The project expects that motivational interview-based communication training will strengthen nursing students' counselling skills and communication self-efficacy, and reduce communication reluctance. The results are intended to provide a scientific contribution to the planning and development of communication training in nursing education programs.",[380,381],"Professional Competence","Health Communication",[383,384,385,386,387,388],"motivational interviewing","nursing students","communication skills","counseling skills","communication self-efficacy","communication reluctance","2026-03-19",{"date":325,"type":34},{"date":352,"type":22},{"date":393,"type":22},"2026-10",{"name":39,"class":40},{"id":396,"slug":4,"hasResults":11,"nctId":397,"briefTitle":398,"officialTitle":399,"acronym":4,"eligibilityCriteria":400,"healthyVolunteers":16,"sex":111,"minAge":401,"maxAge":402,"enrollmentInfo":403,"targetDuration":4,"studyType":23,"phases":404,"briefSummary":405,"conditions":406,"keywords":408,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":413,"lastUpdatePostDateStruct":414,"startDateStruct":416,"completionDateStruct":418,"leadSponsor":420,"locationsCount":78},"100625338","NCT07421336","Effects of Laughter Yoga in Older Adults","EFFECTS OF LAUGHTER YOGA ON PSYCHOLOGİCAL WELL-BEING AND DEPRESSIVE SYMPTOMS IN OLDER ADULTS","Inclusion Criteria:\n\n* Not having a diagnosis of neurocognitive disorders such as Alzheimer's or dementia.\n* Not having a diagnosis of mental disorder\n* Being 65 years and older\n* Literacy\n* Not having communication problems that would prevent answering the data collection form.\n* Volunteering to participate in the research\n\nExclusion Criteria:\n\n* Having a diagnosis of neurocognitive disorders such as Alzheimer's or dementia.\n* Having a diagnosis of mental disorder\n* Being under 60 years of age\n* Illiteracy\n* Having communication problems that prevent one from answering the data collection form.\n* Not volunteering to participate in the research.","60 Years","90 Years",{"count":340,"type":22},[25],"The purpose of this study is to observe the effects of laughter yoga on psychological well-being and depressive symptoms in older adults.",[407],"Laughter Yoga",[409,410,411,412],"laughter yoga","older adults","psychlogical well-being","depressive symptoms","2026-03-02",{"date":415,"type":34},"2026-03-04",{"date":417,"type":34},"2025-12-03",{"date":419,"type":22},"2026-06-30",{"name":39,"class":40},{"id":422,"slug":4,"hasResults":11,"nctId":423,"briefTitle":424,"officialTitle":425,"acronym":4,"eligibilityCriteria":426,"healthyVolunteers":11,"sex":111,"minAge":49,"maxAge":4,"enrollmentInfo":427,"targetDuration":4,"studyType":23,"phases":429,"briefSummary":431,"conditions":432,"keywords":434,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":436,"lastUpdatePostDateStruct":437,"startDateStruct":439,"completionDateStruct":440,"leadSponsor":442,"locationsCount":4},"100589824","NCT06959433","Lu-177 PSMA Treatment in Cell Renal Carcinoma","Safety and Efficacy of Lu-177 PSMA Treatment in Metastatic Clear Cell Renal Carcinoma","Inclusion Criteria:\n\n* Age \\>18\n* Progression after at least 2 lines of systemic therapy or existence of a contraindication to systemic therapies\n* At least 3 years of life expectancy\n* ECOG performance status ≤ 2\n* Ability to sign informed consent\n\nExclusion Criteria:\n\n* Age\\\u003C18\n* Not having received any systemic therapies\n* History of a secondary malignancy\n* ECOG performance status \\> 2\n* Any contraindication for radionuclide therapy (pregnancy, lactation, organ disfunction, metastatic lesions with a risk of compression\n* Previous history of any radionuclide therapies\n* Inability to sign informed consent",{"count":428,"type":22},20,[430],"PHASE3","Summary Renal Cell Carcinoma (RCC) consists of 2% of all malignencies. RCCs are generally divided to histopathological subtypes as clear cell and non-clear cell variants. Clear cell variant responsible for the 75-80% of all RCCs. It is reported that 20-30% of RCCs are metastatic at the diagnosis and 5 years survival is approximately is 10-20% in this group of patients. Moreover, 60% of patients who are not metastatic at the diagnosis, develop metastates within 2-3 years. 2nd and 3th line effective treatment option in metastatic RCCs patients has been a subject of interest.\n\nPSMA (protatate specific membrane antigen) with the other name glutamate carboxypeptidase, is a transmembrane protein and overexpresses in prostate adenocarcinomas and neoangiogenesis spots of endothelium of other several tumor types. It infronts as a target for theranostic consept for mainly prostate cancer in nuclear medicine. As a radionuclide treatment option, Lu-177 PSMA treatment is proved as safe and effective treatment option in castration resistant prostata cancer patients. After its widely use in prostate cancer, it is reported that PSMA molecule can be used for imaging of RCC patients and PSMA uptake is higher than 18F-FDG. For this reason, Lu-177 PSMA treatment can be a systemic treatment option in RCC patients who have progress afer 1st cycle treatment. In this study we aimed to safety and efficacy of Lu-177 PSMA treatment in metastatic RCC patients as systemic radionuclide treatment option.",[433],"Metastatic Renal Cancer",[435],"Renal Cell Carcinoma, Radionuclide treatment, efficacy, safety.","2026-02-26",{"date":438,"type":34},"2026-02-27",{"date":286,"type":22},{"date":441,"type":22},"2028-08-01",{"name":39,"class":40},{"id":444,"slug":4,"hasResults":11,"nctId":445,"briefTitle":446,"officialTitle":446,"acronym":447,"eligibilityCriteria":448,"healthyVolunteers":11,"sex":111,"minAge":49,"maxAge":4,"enrollmentInfo":449,"targetDuration":4,"studyType":23,"phases":451,"briefSummary":452,"conditions":453,"keywords":456,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":460,"lastUpdatePostDateStruct":461,"startDateStruct":462,"completionDateStruct":464,"leadSponsor":466,"locationsCount":331},"100626501","NCT07436455","F-18 Tetrafluoroborate PET\u002FCT in Differentiated Thyroid Cancer","NISDETECT","Inclusion Criteria:\n\n* Having undergone surgery for differentiated thyroid cancer and received radioactive iodine therapy\n* Being evaluated for lesion detection due to elevated serum Tg and\u002For ATg levels during post-treatment follow-up\n* Negative or equivocal I-131 whole-body scan findings\n* Karnofsky Performance Status ≥ 50 (or equivalent Eastern Cooperative Oncology Group \\[ECOG\\]\u002FWorld Health Organization \\[WHO\\] performance status)\n* Giving written informed consent\n\nExclusion Criteria:\n\n* Age under 18 years\n* Pregnancy or breastfeeding\n* Failure to provide written informed consent",{"count":450,"type":22},50,[25],"In patients who have undergone surgery for differentiated thyroid cancer and who demonstrate elevated serum Tg and\u002For ATg levels during follow-up after radioactive iodine therapy, lesion detection is performed using neck ultrasonography, thorax CT, and F-18 FDG PET\u002FCT. Diagnostic whole-body scanning with low-dose I-131 is not routinely recommended in follow-up due to its low sensitivity and specificity.\n\nF-18 TFB is a highly specific imaging agent for differentiated thyroid cancer, entering thyroid follicular epithelial cells via the sodium-iodide symporter (NIS), which is expressed on the cell surface and functions through a mechanism similar to that of I-131. As a PET radiotracer, F-18 TFB has been shown to be superior to I-131 in previous studies.\n\nThe primary aim of this study is to comparatively evaluate the role of F-18 TFB PET\u002FCT versus the standard imaging modality F-18 Fluorodeoxyglucose (FDG) PET\u002FCT in lesion detection in patients with differentiated thyroid cancer who demonstrate elevated serum Tg and\u002For ATg levels during follow-up after radioactive iodine therapy.\n\nThe secondary aims are to investigate the factors predicting F-18 TFB PET\u002FCT positivity and to assess the relationship between the semi-quantitative and quantitative parameters derived from F-18 TFB PET\u002FCT and serum thyroglobulin (Tg) and anti-thyroglobulin (ATg) levels.",[454,455],"Thyroid Cancer","Differentiated Thyroid Cancer",[457,458,459],"F-18-tetrafluoroborate","PET\u002FCT","NIS","2026-02-21",{"date":438,"type":34},{"date":463,"type":34},"2025-11-01",{"date":465,"type":22},"2026-10-01",{"name":39,"class":40},{"id":468,"slug":4,"hasResults":11,"nctId":469,"briefTitle":470,"officialTitle":471,"acronym":472,"eligibilityCriteria":473,"healthyVolunteers":11,"sex":111,"minAge":49,"maxAge":4,"enrollmentInfo":474,"targetDuration":341,"studyType":342,"phases":4,"briefSummary":476,"conditions":477,"keywords":481,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":489,"lastUpdatePostDateStruct":490,"startDateStruct":492,"completionDateStruct":494,"leadSponsor":495,"locationsCount":78},"100624762","NCT07413848","qNOX Response to Nociceptive Motor Events During Procedural Sedation","Performance of the CONOX Monitor Without Neuromuscular Blockade: qCON and qNOX Responses to Nociceptive Motor Events During Procedural Sedation","MO-NOX","Inclusion Criteria:\n\n* Age 18 years or older\n* Scheduled for elective diagnostic or therapeutic urological procedures (cystoscopy, ureteroscopy, prostate biopsy, intradetrusor botulinum toxin injection) under monitored anesthesia care\n* Able to provide written informed consent\n\nExclusion Criteria:\n\n* Known central neurological disease (epilepsy, Alzheimer's disease, Parkinson's disease, stroke) or history of brain surgery\n* Body Mass Index (BMI) ≥35 kg\u002Fm²\n* Known allergy to anesthetic agents used in the study (propofol, fentanyl, lidocaine)",{"count":475,"type":22},120,"The goal of this observational study is to evaluate whether the CONOX monitor can detect pain during sedation in patients undergoing urological procedures. The main questions it aims to answer are:\n\nDoes the qNOX index respond to pain-related motor responses during urological procedural sedation? Does the qNOX index show greater responsiveness to painful episodes compared to blood pressure and heart rate? Participants undergoing urological procedures (such as cystoscopy) under sedation as part of their regular medical care will have continuous brain activity monitoring with the CONOX device. All monitoring displays (CONOX monitor, vital signs monitor, and target-controlled infusion pump) will be video-recorded throughout the procedure to capture synchronized data including qCON, qNOX, EMG, heart rate, blood pressure, oxygen saturation, and drug concentrations. Researchers will analyze the relationship between these indices and spontaneous movements triggered by painful stimulation to evaluate the monitor's performance compared to traditional vital signs.",[478,479,480],"Monitoring Noxious Events Using EEG-Derived Pain Indices","Procedural Sedation and Analgesia","Monitored Anesthesia Care",[482,483,484,485,486,487,488],"EEG Monitoring","CONOX Monitor","qNOX Index","qCON Index","Target Controlled Infusion","Procedural Sedation","Propofol","2026-02-15",{"date":491,"type":34},"2026-02-18",{"date":493,"type":34},"2026-01-14",{"date":156,"type":22},{"name":39,"class":40},{"id":497,"slug":4,"hasResults":11,"nctId":498,"briefTitle":499,"officialTitle":500,"acronym":4,"eligibilityCriteria":501,"healthyVolunteers":11,"sex":111,"minAge":49,"maxAge":113,"enrollmentInfo":502,"targetDuration":504,"studyType":342,"phases":4,"briefSummary":505,"conditions":506,"keywords":509,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":514,"lastUpdatePostDateStruct":515,"startDateStruct":517,"completionDateStruct":519,"leadSponsor":521,"locationsCount":78},"100533001","NCT06220136","Comparison of the Performances of the cTOFR and the mTOFR During Reversal of Deep Neuromuscular Blockade With Sugammadex","Comparison of the Performances of the Train-of-Four Ratio and the Modified Train-of-Four Ratio During Reversal of Deep Neuromuscular Blockade With Sugammadex","Inclusion Criteria:\n\n* Age: 18 - 65 (not including 65)\n* BMI: 18.5-24.9\n\nExclusion Criteria:\n\n* Liver and kidney disease\n* Non-consenting\n* Emergency surgeries\n* Muscle disease\n* Allergy to rocuronium and sugammadex\n* Patients predicted to have difficult mask ventilation or difficult intubation\n* Pregnant and breastfeeding women",{"count":503,"type":22},199,"6 Months","It is known that deep neuromuscular block improves surgical conditions, especially during laparoscopic abdominal surgery. Based on this, in the Perioperative Neuromuscular Blockade Management guide published by the ESAIC association in 2022, it is recommended to deepen the level of neuromuscular blockade in cases where surgical conditions need to be improved. Sugammadex should be used to quickly and reliably reverse deep neuromuscular blockade. TOFScan, a 3-dimensional acceleromyograph for neuromuscular monitoring, has become widely used in recent years. With this monitor, it has been shown that in addition to the classical train-of-four ratio (cTOFR), the modified train-of-four ratio (mTOFR) can be used during the spontaneous recovery of nondepolarizing neuromuscular blockade. In a study conducted by Schmartz et al. in 2021, it was shown that mTOFR, which is the ratio of T4 to the reference stimulus, was compiled later than cTOFR. Therefore, it is suggested that the mTOFR value is a better determinant for safe extubation.",[507,508],"Neuromuscular Blockade","Anesthesia, General",[510,511,512,513],"neuromuscular blockade","neuromuscular junction monitoring","TOFscan","modified TOF ratio","2026-02-11",{"date":516,"type":34},"2026-02-12",{"date":518,"type":34},"2024-06-01",{"date":520,"type":22},"2026-06-01",{"name":39,"class":40},{"id":523,"slug":4,"hasResults":11,"nctId":524,"briefTitle":525,"officialTitle":525,"acronym":526,"eligibilityCriteria":527,"healthyVolunteers":11,"sex":111,"minAge":49,"maxAge":4,"enrollmentInfo":528,"targetDuration":4,"studyType":342,"phases":4,"briefSummary":530,"conditions":531,"keywords":533,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":536,"lastUpdatePostDateStruct":537,"startDateStruct":539,"completionDateStruct":540,"leadSponsor":541,"locationsCount":428},"100619486","NCT07345247","RAdiation SEgmentectomy With REsin Microspheres (RASEREM) Study","RASEREM","Inclusion Criteria:\n\n* Patients aged ≥18 years\n* Underwent RE as a RS intent (have single or \\\u003C3 tumors in same or neighboring 2 segments) for the treatment of HCC or metastatic tumor to liver.\n* Presence of extrahepatic disease\n* Tumor size less than 8 cm\n* Child Pugh Score \\\u003CB9\n\nExclusion Criteria:\n\n* Presence of macrovascular invasion,\n* Presence of extrahepatic disease,\n* Cholangiocarcinoma or mixed HCC-cholangiocarcinoma\n* Not willing to attend follow-up visits.",{"count":529,"type":22},150,"Radiation segmentectomy (RS) refers to selective infusion of Y-90 microspheres to the tumor bearing hepatic segment of hepatic artery. Majority of the data on RS is based on the Glass microspheres experience. Due to different properties of Resin and Glass microspheres description of dose limits to the segment for effectiveness of treatments with Resin microspheres are needed.\n\nBased on this background in this study it is aimed to evaluate the safety and efficacy of RS with resin microspheres in HCC patients. Secondly, it is planned to describe the dose limits for complete radiological response.",[532],"Liver Cancer, Adult",[534,535],"Liver Cancer","Radioembolization","2026-01-20",{"date":538,"type":34},"2026-01-22",{"date":350,"type":34},{"date":441,"type":22},{"name":39,"class":40},{"id":543,"slug":4,"hasResults":11,"nctId":544,"briefTitle":545,"officialTitle":546,"acronym":547,"eligibilityCriteria":548,"healthyVolunteers":11,"sex":111,"minAge":49,"maxAge":4,"enrollmentInfo":549,"targetDuration":4,"studyType":342,"phases":4,"briefSummary":551,"conditions":552,"keywords":555,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":559,"lastUpdatePostDateStruct":560,"startDateStruct":561,"completionDateStruct":563,"leadSponsor":564,"locationsCount":4},"100620143","NCT07353788","Mechanical Power in One-lung Ventilation","Postoperative Complications and Outcomes Related to Mechanical Power in One-lung Ventilation- A Multicentre Observational Study","POWEROL","Inclusion Criteria:\n\n1. Patients aged 18 years or older,\n2. ASA physical status I-IV\n3. All thoracic surgeries\n4. One lung ventilation period \\>1 hour\n5. Patients capable of giving written informed consent\n\nExclusion Criteria:\n\n1-Patients undergoing cardiac surgery",{"count":550,"type":22},300,"Thoracic surgery usually necessitates one-lung ventilation (OLV) to provide surgical access while maintaining adequate gas exchange. However, OLV is associated with an increased risk of PPCs , a major cause of morbidity and mortality. Mechanical power, a composite parameter incorporating tidal volume, respiratory rate, driving pressure, and flow resistance, has been proposed as a key factor influencing ventilator-induced lung injury (VILI) and postoperative outcome. Understanding the association between mechanical power during OLV and PPCs could provide insights for optimizing intraoperative ventilatory strategies and reducing the burden of PPCs. As OLV inherently alters normal lung mechanics by decreasing functional residual capacity and introducing inequalities in ventilation-perfusion ratio, the complexity of managing mechanical power becomes even more pronounced. Under these altered conditions, the risk of PPC-including atelectasis, pneumonia, and respiratory failure-can be significantly elevated. Factors such as ventilatory settings, lung protection strategies, and the duration of OLV play pivotal roles in influencing mechanical power delivery and thereby impacting lung function recovery post-surgery. Current literature indicates a correlation between inappropriate mechanical ventilation strategies during OLV and increased incidence of PPCs. However, there remains a gap in understanding how precisely mechanical power, as a quantifiable measure, influences patient outcomes following OLV. Therefore, this study aims to investigate the relationship between mechanical power during OLV and the subsequent risk of PPC. By elucidating these dynamics, the findings may inform clinical practices surrounding OLV management, ultimately improving patient safety and outcomes in thoracic surgery.",[553,554],"Thoracic Anesthesia","Thoracotomy Surgery",[556,557,558],"one lung ventilation","mechanical power","postoperative pulmonary complications","2026-01-19",{"date":536,"type":34},{"date":562,"type":22},"2026-02-01",{"date":37,"type":22},{"name":39,"class":40},{"id":566,"slug":4,"hasResults":11,"nctId":567,"briefTitle":568,"officialTitle":569,"acronym":570,"eligibilityCriteria":571,"healthyVolunteers":11,"sex":48,"minAge":360,"maxAge":170,"enrollmentInfo":572,"targetDuration":4,"studyType":23,"phases":574,"briefSummary":575,"conditions":576,"keywords":578,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":493,"lastUpdatePostDateStruct":584,"startDateStruct":585,"completionDateStruct":586,"leadSponsor":588,"locationsCount":78},"100619852","NCT07350005","Comparison of Holmium, Thulium:YAG, and Thulium Fiber Lasers in Prostate Enucleation","A Prospective Randomized Study Comparing the Efficiency and Safety of Holmium:YAG, Thulium:YAG, and Thulium Fiber Lasers in Anatomical Prostate Enucleation","TRI-LASER","Inclusion Criteria:\n\n* Patients diagnosed with benign prostatic hyperplasia (BPH) and scheduled for anatomical prostate enucleation\n* Presence of a prostate and clinical indication for surgical treatment\n* Age between 50 and 80 years\n\nExclusion Criteria:\n\n* History or suspicion of prostate cancer\n* Previous prostate surgery\n* Presence of neurogenic bladder or significant lower urinary tract dysfunction unrelated to BPH\n* Active urinary tract infection at the time of surgery\n* Severe comorbid conditions contraindicating surgery or anesthesia",{"count":573,"type":22},159,[25],"Benign prostatic hyperplasia (BPH) is a common condition in aging men and may require surgical treatment when medical therapy is ineffective. Anatomical prostate enucleation using different laser technologies is a well-established surgical approach for the treatment of BPH.\n\nThe purpose of this prospective randomized study is to compare the efficiency and safety of three commonly used laser systems-Holmium:YAG, Thulium:YAG, and Thulium Fiber Laser (TFL)-during anatomical prostate enucleation.\n\nThe primary objective of the study is to evaluate laser efficiency by measuring grams of enucleated prostate tissue per joule (g\u002FJ) using intraoperative laser device data. Secondary outcomes include changes in International Prostate Symptom Score (IPSS) and the occurrence of postoperative urinary incontinence.\n\nAll laser systems used in this study are part of routine clinical practice, and no additional diagnostic procedures or treatments will be performed for study purposes",[577],"BPH (Benign Prostatic Hyperplasia)",[579,580,581,582,583],"bph","prostate","holmium","thulium","TFL",{"date":536,"type":34},{"date":352,"type":22},{"date":587,"type":22},"2028-01",{"name":39,"class":40},{"id":590,"slug":4,"hasResults":11,"nctId":591,"briefTitle":592,"officialTitle":593,"acronym":594,"eligibilityCriteria":595,"healthyVolunteers":11,"sex":111,"minAge":49,"maxAge":4,"enrollmentInfo":596,"targetDuration":4,"studyType":23,"phases":598,"briefSummary":599,"conditions":600,"keywords":602,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":608,"lastUpdatePostDateStruct":609,"startDateStruct":611,"completionDateStruct":612,"leadSponsor":614,"locationsCount":78},"100618138","NCT07327723","Effects of Repetitive Peripheral Magnetic Stimulation(rPMS) on CTS(Carpal Tunnel Syndrome)","The Effects of Repetitive Peripheral Magnetic Stimulation on Clinical and Electrophysiological Parameters in Patients With Carpal Tunnel Syndrome: A Double-Blind, Randomized, Sham-Controlled Trial","rPMS CTS","Inclusion Criteria\n\n* Voluntary participation with signed informed consent\n* Presence of symptoms consistent with carpal tunnel syndrome (CTS) (pain and\u002For paresthesia in the median nerve distribution), clinical signs (i.e., positive Tinel's and\u002For Phalen's test results), and electrodiagnostic findings (demonstrating mild to moderate CTS based on sensory or motor conduction studies of the median nerve)\n\nExclusion Criteria:\n\n* Electrodiagnostic evidence of severe CTS\n* Abnormal ulnar nerve conduction findings\n* History of surgery for CTS\n* History of physical therapy or injection for CTS within the past 6 months\n* History of wrist fracture\n* Presence of other conditions causing similar symptoms, such as polyneuropathy, cervical radiculopathy, ulnar neuropathy, brachial plexopathy, or thoracic outlet syndrome\n* Central nervous system disorders (e.g., stroke, multiple sclerosis, Parkinson's disease)\n* Pregnancy\n* Presence of risk factors for CTS such as rheumatologic diseases, chronic kidney disease, diabetes mellitus, or hypothyroidism\n* Malignancy\n* Contraindications to rPMS (e.g., pacemaker, cochlear implant)",{"count":597,"type":22},40,[25],"Carpal tunnel syndrome (CTS) is the most common entrapment neuropathy, resulting from compression of the median nerve at the wrist. It is particularly common in middle-aged women. In the early stages, these patients frequently experience pain and numbness in the hand, especially in the first three fingers, and paresthesias, which often worsen at night. As the disease progresses, muscle weakness and atrophy of the thenar muscles can occur, severely impacting patients' daily activities and functionality. Clinical evaluation and patient complaints are crucial for diagnosis. Electrophysiological assessment tools such as nerve conduction studies and electromyography (EMG) are highly sensitive and considered the gold standard for confirming the diagnosis, assessing nerve damage, and determining the severity of this damage. In addition to electrophysiological assessment, ultrasonographic evaluation offers an important opportunity to observe structural changes in the median nerve associated with CTS.\n\nIn cases of mild to moderate CTS, nonsurgical treatments are the primary options for reducing symptoms; splinting, tendon-nerve gliding exercises, and physical therapy modalities are commonly preferred. Repetitive peripheral magnetic stimulation (rPMS) is a non-invasive method that can be applied to various tissues, such as spinal nerves, peripheral nerves, or muscles, and is used to reduce pain and improve motor function. While its potential benefits for many neurological diseases and musculoskeletal problems have been demonstrated in recent years, there are limited studies on the effectiveness of rPMS in patients with CTS. The primary objective of this study is to evaluate the effectiveness of rPMS on pain in individuals diagnosed with mild to moderate CTS. Secondarily, the effects of rPMS on symptom severity, functional status, nerve conduction parameters, and median nerve ultrasonographic findings will be analyzed. The findings of our study suggest that objective evaluation of rPMS treatment will contribute to supporting the clinical practice of this treatment option in patients with CTS with more comprehensive data.",[601],"Carpal Tunnel Syndrome (CTS)",[603,604,605,606,607],"Carpal Tunnel Syndrome","Repetitive Peripheral Magnetic Stimulation","electrodiagnosis","ultrasound","functional status","2025-12-25",{"date":610,"type":34},"2026-01-08",{"date":160,"type":22},{"date":613,"type":22},"2027-01-15",{"name":39,"class":40},{"id":616,"slug":4,"hasResults":11,"nctId":617,"briefTitle":618,"officialTitle":619,"acronym":4,"eligibilityCriteria":620,"healthyVolunteers":11,"sex":111,"minAge":621,"maxAge":622,"enrollmentInfo":623,"targetDuration":4,"studyType":23,"phases":625,"briefSummary":626,"conditions":627,"keywords":630,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":635,"lastUpdatePostDateStruct":636,"startDateStruct":637,"completionDateStruct":639,"leadSponsor":641,"locationsCount":78},"100607375","NCT07187739","Effect of Mediterranean Diet on Nutrition in Parkinson's Disease Patients With Bilateral Subthalamic Deep Brain Stimulation","Investigation of the Effect of the Mediterranean Diet on Nutritional Status in Parkinson's Patients Undergoing Bilateral Subthalamic Nucleus Deep Brain Stimulation","Inclusion Criteria:\n\n* Being between 45-64 years of age\n* Signing informed consent\n* Undergoing STN DBS surgery\n* Continuing antiparkinsonian therapy\n* Those with a Mini Mental Test result of ≥24 points\n\nExclusion Criteria:\n\n* Having any psychiatric illness\n* Those with a Mini Mental Test result of \\\u003C24 points\n* Those with a disease requiring a special diet other than Parkinson's Disease","45 Years","64 Years",{"count":624,"type":22},24,[25],"The goal of this clinical trial is to evaluate whether Mediterranean diet can help manage body weight and improve body composition in adult Parkinson's disease patients who have undergone bilateral subthalamic nucleus deep brain stimulation (STN DBS).\n\nThe main questions it aims to answer are:\n\nDoes adherence to the Mediterranean diet for three months post-surgery help control body weight gain in STN DBS patients?\n\nDoes the Mediterranean diet positively affect body composition and other clinical parameters such as nutritional status, appetite, quality of life, and physical activity?\n\nResearchers will compare an intervention group following the Mediterranean diet with a control group continuing their usual diet to see if dietary guidance leads to improvements in weight management, body composition, and other nutritional status parameters.\n\nParticipants will:\n\nBe randomized into intervention and control groups.\n\nReceive Mediterranean dietary recommendations (intervention group) or continue usual diet (control group).\n\nUndergo evaluations at baseline (pre-operative), and at the 1st, 2nd, and 3rd months post-operatively using the following tools:\n\nVisual Appetite Scale\n\nHoehn and Yahr Questionnaire\n\nParkinson's Disease Quality of Life Questionnaire-8\n\nMovement Disorder Society-Unified Parkinson's Disease Rating Scale - Part 2\n\nMediterranean Diet Adherence Scale\n\nFood Consumption Record\n\nHave their anthropometric measurements and body composition (e.g., weight, waist and neck circumference, upper arm circumference, handgrip strength) assessed.",[121,628,629],"Deep Brain Stimulation","Deep Brain Stimulation Surgery",[631,632,633,634,121],"Mediterranean Diet","Body Weight","Body Composition","Dietary Assesment","2025-11-26",{"date":417,"type":34},{"date":638,"type":34},"2025-09-25",{"date":640,"type":22},"2026-03",{"name":39,"class":40},""]