[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Aquilo Sports, LLC\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":39},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":10,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":5},"100642091",false,"NCT07653243","Home-Based Lower-Extremity Heat Therapy for Walking Function in Peripheral Artery Disease","A Randomized, Sham-Controlled Trial of Home-Based Lower-Extremity Heat Therapy in Adults With Peripheral Artery Disease","Inclusion Criteria:\n\n* Men and women older than 50 years of age\n* Resting ankle-brachial index (ABI) of \\\u003C0.9 but \\>0.4 in at least one leg\n\nExclusion Criteria:\n\n* Critical limb ischemia (ischemic rest pain or ischemia-related, non-healing wounds or tissue loss\n* Prior amputation\n* Exercise-limiting comorbidity\n* Recent (\\\u003C3 months) lower-extremity revascularization or orthopedic surgery\n* Use of walking aid other than a cane\n* Active treatment for cancer\n* Chronic kidney disease (eGFR \\\u003C30 by MDRD or Mayo or Cockcroft-Gault formula)\n* Class 2 or 3 obesity (BMI ≥ 35 kg\u002Fm2)\n* Unable to fit into water-circulating trousers","ALL","50 Years",{"count":18,"type":19},40,"ESTIMATED","INTERVENTIONAL",[22],"NA","Lower-extremity peripheral artery disease is associated with impaired walking ability, reduced lower-extremity function, and decreased quality of life. This randomized, sham-controlled clinical trial will evaluate the effects of 12 weeks of home-based lower-extremity heat therapy on walking function and mobility in adults with peripheral artery disease.\n\nA total of 40 participants will be randomized to active lower-extremity heat therapy or sham therapy. Participants assigned to active therapy will complete daily 90-minute home treatment sessions using heated lower-extremity garments. Participants assigned to sham therapy will complete the same treatment schedule using a lower-temperature sham condition.\n\nThe primary outcome is the change in six-minute walk distance from baseline to 12 weeks. Secondary outcomes include changes in leg strength and fatigability, Short Physical Performance Battery score, blood pressure, and patient-reported quality of life.",[25,26],"PAD","PAD - Peripheral Arterial Disease","NOT_YET_RECRUITING","2026-06-12",{"date":30,"type":31},"2026-06-17","ACTUAL",{"date":33,"type":19},"2027-01-01",{"date":35,"type":19},"2029-06-30",{"name":37,"class":38},"Aquilo Sports, LLC","INDUSTRY",""]