[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Azienda Sanitaria dell'Alto Adige\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":76},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,49],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":10,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":4},"100629163",false,"NCT07471100","Neuromodulation-Induced Cortical Prehabilitation in High Grade Glioma Near the Motor Pathway: Cortical Plasticity Assessed by Navigated Transcranial Magnetic Stimulation (nTMS)","Neuromodulation-Induced-Cortical-Prehabilitation In High Grade Glioma Close To The Motor Pathway: Analysis Of The Cortical Brain Plasticity Through Navigated Transacranial Magnetic Stimulation","Inclusion Criteria:\n\n1. Age 18-80\n2. Suspect of High Grade Glioma in MRI\n3. Any case of cortical\u002Fsubcortical HGG radiologically close to Motor Pathway and, thus, where intraoperative monitoring assistance is usually required\n4. Preservation of motor function (at least ≥ 3 according to Medical Research Council classification)\n5. Signed informed Consent\n\nExclusion Criteria:\n\n1. Refusal to Study participation\n2. Multifocal\u002FBilateral Disease","ALL","18 Years","80 Years",{"count":19,"type":20},63,"ESTIMATED","INTERVENTIONAL",[23],"NA","The goal of this clinical trial is to learn whether Neuromodulation-Induced-Cortical-Prehabilitation (NICP)-using physical therapy (constraint-induced movement training, CIM) alone or combined with repetitive transcranial magnetic stimulation (rTMS)-can promote motor-cortex neuroplasticity before surgery in adults with high-grade gliomas near the motor pathway. It will also learn about the feasibility and safety of these prehabilitation strategies around the time of surgery. The main questions it aims to answer are:\n\n1. Does CIM (with or without rTMS) produce measurable motor-cortex plasticity from baseline to pre-surgery as assessed by neuronavigated TMS (nTMS)?\n2. Does adding rTMS to CIM lead to greater neuroplastic changes than CIM alone?\n3. What clinical, radiological, and neurophysiological outcomes are observed after surgery in participants who receive prehabilitation compared with controls?\n\nResearchers will compare standard care (control) vs CIM-based physical therapy vs CIM plus rTMS to see if these approaches induce preoperative neuroplastic changes that may support better surgical outcomes. Participants will:\n\n1. Be randomized to one of three groups: control, CIM physical therapy, or CIM + rTMS• Undergo nTMS motor mapping and excitability testing at baseline (T0) and the day before surgery (T1)\n2. Undergo planned tumor surgery (according to standard methods of care) and complete postoperative clinical, imaging, and neurophysiological follow-up assessments.",[26,27,28],"Brain Tumor Adult","Glioma","Glioma, High Grade",[30,31,32,33,34,35,36],"prehabilitation","neuromodulation","brain plasticity","cortical plasticity","rTMS","nTMS","physical therapy","NOT_YET_RECRUITING","2026-03-11",{"date":40,"type":41},"2026-03-13","ACTUAL",{"date":43,"type":20},"2026-04-01",{"date":45,"type":20},"2030-03-31",{"name":47,"class":48},"Azienda Sanitaria dell'Alto Adige","OTHER",{"id":50,"slug":4,"hasResults":10,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":10,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":58,"phases":4,"briefSummary":59,"conditions":60,"keywords":64,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":75},"100437471","NCT04976712","Core Temperature in Patients With OHCA","Core Temperature in Patients With Out of Hospital Cardiac Arrest in South Tyrol - a Prospective Observational Study","CT-OCHA","Inclusion Criteria:\n\n* Out of hospital cardiac arrest\n* Patients transferred to hospital\n* \\> 18 years\n\nExclusion Criteria:\n\n* Obvious signs of death\n* Obvious lethal injury\u002Finjuries incompatible with life\n* Confirmation of death on scene\n* \\\u003C 18 years",{"count":57,"type":20},256,"OBSERVATIONAL","A prospective observational study aiming to monitor core temperature via an esophageal probe in out of hospital cardiac arrest during transport and until arrival in hospital. Insertion of an esophageal temperature probe will be done on scene during ongoing resuscitation manoeuvres based on European Resuscitation Council Guidelines 2015 (or newer). Environmental temperature influence and hypothermia prevention interventions will be monitored.",[61,62,63],"Out-Of-Hospital Cardiac Arrest","Accidental Hypothermia","Temperature Change, Body",[61,62,65],"Core Temperature","RECRUITING","2022-12-16",{"date":69,"type":41},"2022-12-20",{"date":71,"type":41},"2021-07-01",{"date":73,"type":20},"2026-09-30",{"name":47,"class":48},1,""]