[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Azienda ULSS 8 Berica\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":89},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,62],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":10,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":28,"overallStatus":49,"whyStopped":4,"lastUpdateSubmitDate":50,"lastUpdatePostDateStruct":51,"startDateStruct":54,"completionDateStruct":56,"leadSponsor":58,"locationsCount":61},"100630843",false,"NCT07492940","Hands-on vs Hands-off Techniques in Perineal Protection","The Midwife's Hands Between Waiting and Support: Hands-off vs hands-on Techniques in Manual Perineal Protection.","MPP","Criteri di inclusione:\n\n* Donne incinte nullipare o multipare\n* Gravidanza a termine\n* Feto nella presentazione cefalica\n* Consegna eutocic (spontanea)\n* Uso di ossitocina\n* Uso di analgesici\n\nCriteri di esclusione:\n\n* Parto prematuro: prematuro tardivo -Disagio fetale acuto durante la fase di espulsione-\n* Consegna della gretta\n* Distocia della spalla\n* Parto chirurgico (uso del vuoto ostetrico, manovra di Kristeller, taglio cesareo) --Episiotomia","FEMALE","18 Years",{"count":19,"type":20},737,"ESTIMATED","OBSERVATIONAL","Perineal tears are frequent during vaginal delivery. This study evaluates the impact of hands-on versus hands-off techniques on perineal and neonatal outcomes to determine the most effective protective strategy.",[24,25,26,27],"Perineal Trauma","Hands-on Technique","Hands-of Technique","Manual Perineal Protection",[29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48],"Perineal trauma","Perineal injury","Perineal lacerations","Perineal tears","Obstetric anal sphincter injuries","OASIS","Genital tract trauma","Labial lacerations","Labial tears","Vaginal tears","Pelvic floor muscle injury","Levator ani muscle avulsion","First-degree perineal tear","Second-degree perineal tear","Third-degree perineal tear","Fourth-degree perineal tear","hands on","hands off","hands-on technique","hands-off technique","RECRUITING","2026-03-20",{"date":52,"type":53},"2026-03-25","ACTUAL",{"date":55,"type":20},"2026-03-05",{"date":57,"type":20},"2027-03",{"name":59,"class":60},"Azienda ULSS 8 Berica","OTHER",1,{"id":63,"slug":4,"hasResults":10,"nctId":64,"briefTitle":65,"officialTitle":65,"acronym":66,"eligibilityCriteria":67,"healthyVolunteers":10,"sex":68,"minAge":17,"maxAge":4,"enrollmentInfo":69,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":71,"conditions":72,"keywords":75,"overallStatus":49,"whyStopped":4,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},"100626520","NCT07436702","Optimal Time for Reperfusion in Acute Pulmonary Embolism","OPTIRAPE","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Patients with a diagnosis of intermediate-high or high pulmonary embolism confirmed by computed tomography pulmonary angiography (CTPA), pulmonary angiography, or echocardiography (evidence of a floating thrombus in the right atrium or right ventricle, or proximal visualization of thrombus in the pulmonary artery).\n* Classified as high-risk or intermediate-high-risk according to the 2019 European Society of Cardiology guidelines.\n* Provision of informed consent for the processing of personal data.\n\nExclusion Criteria:\n\n* Age \\\u003C 18 years\n* Patients in whom a diagnosis of acute high-risk or intermediate-high-risk pulmonary embolism has been excluded.\n* Inability to provide informed consent.","ALL",{"count":70,"type":20},500,"Pulmonary embolism (PE) is the third leading cause of cardiovascular mortality worldwide. Current guidelines recommend early reperfusion for high-risk and intermediate-high-risk PE, yet systemic thrombolysis and percutaneous therapies are frequently underutilized, and no specific timing for reperfusion is defined, unlike in acute myocardial infarction or ischemic stroke. As most PE-related in-hospital deaths occur within the first hours and thrombus composition changes over time, defining an optimal reperfusion time window may improve survival and prevent hemodynamic deterioration. We therefore propose a national, multicenter, prospective observational study to evaluate the prognostic impact of reperfusion timing, using systemic thrombolysis or catheter-directed therapies, on in-hospital mortality and haemorrhagic or cardiovascular complications.",[73,74],"Pulmonary Embolism (Diagnosis)","Pulmonary Embolism Acute",[76,77,78,79],"Fibrinolysis","Anticoagulation","Catheter-directed treatments","Time of Reperfusion","2026-03-01",{"date":82,"type":53},"2026-03-03",{"date":84,"type":53},"2025-11-25",{"date":86,"type":20},"2026-10-30",{"name":59,"class":60},7,""]