[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"B.P. Koirala Institute of Health Sciences\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":89},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,39,66],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":10,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":21,"conditions":22,"keywords":24,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":27,"lastUpdatePostDateStruct":28,"startDateStruct":31,"completionDateStruct":33,"leadSponsor":35,"locationsCount":38},"100501068",false,"NCT05804448","Effect of Altitude on Postdural Puncture Headache After Caesarean Delivery","Effect of Altitude on Postdural Puncture Headache After Caesarean Delivery: a Prospective, Multicentre Cohort Study","Inclusion Criteria:\n\n* Parturient, aged more than or equal to 18 years\n* American society of Anesthesiologist 2 and 3\n* Scheduled for elective and non-elective (category 2 \\& 3) caesarean delivery with spinal anesthesia\n* Native to their resident altitude i.e., those born, raised, and have continuously lived at the same altitude, at least for the past 1 year.\n\nExclusion Criteria:\n\n* Hypertensive disorder\n* Cerebrovascular disease\n* Mental disorder (schizophrenia and other psychotic disorders)\n* Known fetal anomalies\n* Contraindication to spinal anaesthesia.\n* Those requiring general anaesthesia for delivery due to failed spinal anesthesia\n* Major post-delivery complications (severe haemorrhage, sepsis, or ICU admission)\n* Those who migrate from their resident altitude (either low to high or vice versa) within 7 days post-delivery will also be excluded.","FEMALE","18 Years",{"count":18,"type":19},292,"ESTIMATED","OBSERVATIONAL","The aim of this study is to examine the effects of altitude (high altitude versus low altitude) on incidence and severity of postural puncture headache (PDPH) following spinal anaesthesia for caesarean delivery. The investigators hypothesized that the risk of PDPH would be higher in highlander parturients than in lowlander parturients.",[23],"Post-Dural Puncture Headache",[25],"Spinal Anesthesia, Cesarean Section","RECRUITING","2025-09-16",{"date":29,"type":30},"2025-09-19","ACTUAL",{"date":32,"type":30},"2023-04-18",{"date":34,"type":19},"2026-04-20",{"name":36,"class":37},"B.P. Koirala Institute of Health Sciences","OTHER",2,{"id":40,"slug":4,"hasResults":10,"nctId":41,"briefTitle":42,"officialTitle":42,"acronym":4,"eligibilityCriteria":43,"healthyVolunteers":44,"sex":45,"minAge":16,"maxAge":4,"enrollmentInfo":46,"targetDuration":4,"studyType":48,"phases":49,"briefSummary":51,"conditions":52,"keywords":54,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":57,"lastUpdatePostDateStruct":58,"startDateStruct":60,"completionDateStruct":62,"leadSponsor":64,"locationsCount":65},"100570937","NCT06713733","Comparison of Clinical Efficacy of Submucosal Dexamethasone and Oral Trypsin-chymotrypsin for Reduction of Postoperative Sequelae After Lower Third Molar Surgery","Inclusion Criteria:\n\n* Clinically healthy patients (ASA I) patient free of any systemic diseases that could interfere with wound healing or surgical operation.\n* Free of any recent anti-inflammatory drug intake or being under long term treatment with medicaments that will obscure the assessment of the inflammatory response as NSAIDs, steroids, or antihistamines\n* Free from allergy to the drugs used in the study\n* Patients requiring surgical removal of the mandibular impacted third molar\n\nExclusion Criteria:\n\n* Patients who are ASA II to ASA VI.\n* Patients already on corticosteroids through any route.\n* Patients with known allergy to any drugs.\n* Pregnant and lactating females\n* Patient not consenting to participate in the study",true,"ALL",{"count":47,"type":19},50,"INTERVENTIONAL",[50],"NA","Pain, edema and trismus are the most frequent postoperative sequelae to surgical removal of impacted teeth, all of are due to the local inflammatory response.\n\nUse of corticosteroids decrease tissue mediators of inflammation and reduce edema.\n\nUse of trypsin-chymotrypsin elaborates the enzymes esterase in blood plasma that inhibits inflammation by hydrolytic degradation of the inflammatory peptides.",[53],"Clinical Efficacy of Submucosal Dexamethasone and Oral Trypsin Chymotrypsin for Reduction of Postoperative Sequelae After Lower Third Molar Surgery",[55,56],"Dexamethasone","Trypsin-chymotrypsin","2024-11-27",{"date":59,"type":30},"2024-12-03",{"date":61,"type":30},"2024-09-25",{"date":63,"type":19},"2025-01-25",{"name":36,"class":37},1,{"id":67,"slug":4,"hasResults":10,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":4,"eligibilityCriteria":71,"healthyVolunteers":44,"sex":45,"minAge":16,"maxAge":72,"enrollmentInfo":73,"targetDuration":4,"studyType":48,"phases":75,"briefSummary":77,"conditions":78,"keywords":4,"overallStatus":80,"whyStopped":4,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":4},"100528393","NCT06160180","Comparative Assessment of Preoperative Versus Postoperative Submucosal Dexamethasone on Postoperative Complications Following Surgical Extraction of Mandibular Third Molar: Randomized Controlled Trial","Randomized Controlled Trial on Assessment of Preoperative Versus Postoperative Submucosal Dexamethasone On Postoperative Complications Following Surgical Extraction Of Mandibular Third Molar.","Inclusion Criteria:\n\n* Clinically healthy patients (American Society of Anesthesiology I) with impacted lower third molar.\n* Age ≥18 to ≤ 55 years\n* No history of previous pericoronitis\n\nExclusion Criteria:\n\n* • Patients who are ASA II to ASA VI.\n\n  * Patients already on corticosteriods through any route.\n  * Patients with known allergy to any drugs.\n  * Pregnant and lactating females\n  * Patient not consenting to participate in the study","55 Years",{"count":74,"type":19},60,[76],"PHASE4","The goal of this study is to compare the pain, edema and trismus of pre-operative versus post-operative submucosal dexamethasone in lower third molar surgical extraction done in healthy population.This is comparative study, will be conducted in patient indicated for surgical extraction of mandibular third molar at the department of oral and maxillofacial surgery, college of dental surgery, BPKIHS, Nepal. Verbal and written informed consent will be taken. Participants meeting inclusion criteria will be included in the study and will be divided into two groups, group A(pre-operative submucosal 2ml of 4mg\u002Fml dexamethasone will be administered prior to placing an incision in buccal vestibule) and groupB(post-operative submucosal 2ml of 4mg\u002Fml dexamethasone will be administered soon after closure of the incision site).Baseline measurement of interincisal distance for mouth opening, distance between the tragus to corner of mouth, gonion to corner of mouth and outer canthus to gonion as baseline for edema taken prior extraction. Extraction is carried out using standard protocol and postoperative antibiotics and analgesics are given. Rescue analgesic tramadol is prescribed and asked to be taken only pain score exceeds 7.Patient is kept on follow up for 2nd, 5th and 7th days and assessment of pain using numeric visual analogue scale, swelling using facial and trismus using interincial measurements and recorded. Any adverse effect of drugs will be recorded. The data collected will be entered in Microsoft excel sheet. It will then be transferred into SPSS(Statistical package for Social Sciences) for statistical analysis.",[79],"Pain, Postoperative","NOT_YET_RECRUITING","2024-08-07",{"date":83,"type":30},"2024-08-09",{"date":85,"type":19},"2024-08",{"date":87,"type":19},"2024-12",{"name":36,"class":37},""]