[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"CNS Onlus\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":41},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":12,"acronym":13,"eligibilityCriteria":14,"healthyVolunteers":10,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":5},"100337120",false,"NCT03669315","Modulating Inhibitory Control Networks in Gambling Disorder With Theta Burst Stimulation","TMS-GD","Inclusion Criteria:\n\n1. DSM-5 diagnosis of Gambling Disorder\n2. Age between 18 and 65 years\n\nExclusion Criteria:\n\n1. any additional current psychiatric comorbidity, except for nicotine addiction;\n2. a lifetime DSM-5 diagnosis of schizophrenia or other psychotic syndromes, substance dependence or substance abuse, including alcohol, bipolar I or II disorder, mental disorder due to a general medical condition;\n3. serious suicide risk;\n4. illness duration less than two years;\n5. hospitalization in the last 6 months;\n6. the inability to receive TMS because of metallic implants, or history of seizures (personal or family history of seizure in first degree relatives);\n7. any major medical disease;\n8. pregnancy or nursing of an infant;\n9. the inability or refusal to provide written informed consent.","ALL","18 Years","65 Years",{"count":19,"type":20},40,"ESTIMATED","INTERVENTIONAL",[23],"PHASE3","In this project the investigators propose a randomized double-blind placebo-controlled design in which 40 patients with GD will receive active or sham cTBS to the pre-SMA for 2 weeks. The investigators will combine TMS, multimodal structural and functional MRI and behavioral measures in order to identify circuit-level mechanisms of action and therapeutic targets (connectivity changes that explain clinical improvement) and assess the efficacy of TMS in modulating inhibitory control and symptom severity in this population.",[26],"Gambling Disorder",[26,28],"Transcranial Magnetic Stimulation","RECRUITING","2018-09-11",{"date":32,"type":33},"2018-09-13","ACTUAL",{"date":35,"type":33},"2018-05-20",{"date":37,"type":20},"2019-12-01",{"name":39,"class":40},"CNS Onlus","OTHER",""]