[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Candiolo Cancer Institute - IRCCS\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":74},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,50],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":10,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":25,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100597743",false,"NCT07062458","A Comparative Study of Nipple Sensation Preservation After Nipple-Sparing Mastectomy With Conventional, Endoscopic, Robotic Techniques","NIPSENSE - A Comparative Study of Nipple and Skin Sensation Preservation After Nipple-Sparing Mastectomy With Conventional, Endoscopic, and Robotic Techniques","NIPSENSE","Inclusion Criteria:\n\n* Female patients aged ≥18 years.\n* Diagnosed with early-stage breast cancer or deemed at high risk for breast cancer (eg. BRCA1-2 mutations).\n* Candidates for Nipple-Sparing Mastectomy (NSM).\n* Able to provide informed consent.\n* No contraindications for surgery based on physical examination and preoperative assessment.\n* Signed the consent forms and willing to participate in all scheduled follow-up assessments.\n\nExclusion Criteria:\n\n* Previous breast surgery.\n* History of radiation therapy to the chest\u002Fbreast area.\n* Active or non-controlled diabetes mellitus.\n* Neuropathies causing potentially altered skin sensation.\n* Nipple involvement by cancer, clinical or reported intra-operatively via frozen section analysis (the procedure will be converted to SSM).","FEMALE","18 Years",{"count":19,"type":20},90,"ESTIMATED","OBSERVATIONAL","The goal of this comparative study is to learn how different surgical methods affect nipple and skin sensation after nipple-sparing mastectomy (NSM). The study will compare three types of NSM: conventional, endoscopic, and robotic.\n\nThe main question it aims to answer is:\n\nHow much nipple sensation do participants keep after each type of surgery?\n\nResearchers will also look at surgery-related complications, patient-reported outcomes like body image and quality of life, and tissue analysis to see if there is a link between nerve structures and sensation.\n\nParticipants will:\n\nHave NSM using one of the three surgical approaches\n\nReceive breast reconstruction with an implant during the same surgery\n\nComplete nipple sensation tests before and at 1, 3, and 6 months after surgery\n\nAnswer surveys about their quality of life and body image\n\nProvide surgical tissue for analysis (as part of the planned procedure)",[24],"Sensation Disorder",[26,27,28,29,30,31,32,33,34,35,36],"Nipple sensation","Sensory outcomes","Quality of life","Endoscopic breast surgery","Robotic breast surgery","Breast cancer surgery","Nipple-sparing mastectomy","Breast reconstruction","R-NSM","E-NSM","conventional mastectomy","RECRUITING","2025-07-10",{"date":40,"type":41},"2025-07-14","ACTUAL",{"date":43,"type":41},"2025-06-01",{"date":45,"type":20},"2027-12-01",{"name":47,"class":48},"Candiolo Cancer Institute - IRCCS","OTHER",1,{"id":51,"slug":4,"hasResults":10,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":10,"sex":16,"minAge":17,"maxAge":57,"enrollmentInfo":58,"targetDuration":60,"studyType":21,"phases":4,"briefSummary":61,"conditions":62,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":49},"100551336","NCT06458764","Sexual Dysfunction Check-up in Premenopausal Breast Cancer Survivors Taking Endocrine Therapy: A Cross-Sectional Study","SEXCHECK - Sexual Dysfunction Check-up in Premenopausal Breast Cancer Survivors Taking Endocrine Therapy: A Cross-Sectional Study","SEXCHECK","Inclusion Criteria:\n\n* women aged ≥18 and ≤ 55\n* who underwent surgery for early stage breast cancer\n* taking endocrine therapy for at least 3 months\n* providing an informed consent and completing the study questionnaires.\n\nExclusion Criteria:\n\n* withdrawal of the informed consent, at any time","55 Years",{"count":59,"type":20},150,"1 Month","Primary objectives:\n\n* To estimate Sexual Dysfunction (SD) incidence in premenopausal breast cancer patients treated by surgery and taking endocrine therapy.\n* To detect the presence of SD-related distress in the population, as a determining factor in the maintenance of a good quality of life.\n\nSecondary objectives:\n\n* To describe SD characteristics determining the most frequently reported symptoms and correlations with type of surgery or therapeutic regimens.\n* Collect baseline data for subsequent randomized trials involving practical interventions with the aim to reduce SD prevalence in this population.",[63,64,65],"Breast Cancer Female","Sexual Dysfunction","Premenopausal Breast Cancer","2025-06-18",{"date":68,"type":41},"2025-06-24",{"date":70,"type":41},"2023-05-01",{"date":72,"type":20},"2025-12-01",{"name":47,"class":48},""]