[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Claudia Schuurhuizen\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":43},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":10,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":5},"100640978",false,"NCT07616297","Higher Radiation Dose to the Tumor May Help Avoid Surgery in Rectal Cancer Patients","REctal Organ Preservation With a BOost Approach Using CBCT-based Online Adaptive radioTherapy","REBOOT","Inclusion Criteria:\n\n* Age ≥18 years\n* Eastern cooperative oncology group (ECOG) performance status ≤2\n* Histologically confirmed rectal adenocarcinoma\n* Non-locally advanced rectal cancer, defined as (magnetic resonance imaging (MRI)-based) T1-3, N0\u002FN1 (≤3 positive mesorectal lymph nodes), MX\u002FM0\n* Indication for curative treatment with organ preservation\n* Discussed in the multidisciplinary tumor board (MTB)\n* Written informed consent\n\nExclusion Criteria:\n\n* Previous radiotherapy in the pelvic area\n* Other malignancies, except for adequately treated basal cell carcinoma (BCC), at time of inclusion or within 3 years prior to inclusion\n* Contra-indications for (chemo)radiotherapy or surgery\n* Presence of lateral lymph nodes, cN2 status, extramural vascular invasion (EMVI) or mesorectal fascia involvement as seen on MRI\n* Mucinous defined tumor on MRI\n* Prior local excision of the primary tumor\n* DPD (dihydropyrimidine dehydrogenase) deficiency\n* Unable to understand the requirements of the study and to give written informed consent, as determined by the treating physician","ALL","18 Years",{"count":19,"type":20},25,"ESTIMATED","INTERVENTIONAL",[23],"NA","The goal of this prospective study is to evaluate if a higher radiation dose to the tumor can increase the organ preservation rate in non-locally advanced rectal cancer.",[26,27],"Rectal Cancer","Radiation Oncology",[27,29,30],"Rectal cancer","Organ Preservation","RECRUITING","2026-05-29",{"date":34,"type":35},"2026-06-01","ACTUAL",{"date":37,"type":35},"2026-01-27",{"date":39,"type":20},"2030-08-01",{"name":41,"class":42},"Claudia Schuurhuizen","OTHER",""]