[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Damian Ratano\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":45},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":10,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":5},"100383511",false,"NCT04273607","Anticoagulation-free VV ECMO for Acute Respiratory Failure","Anticoagulation-free VV ECMO for Acute Respiratory Failure: A Pilot Safety and Feasibility Randomized Clinical Trial","A-FREE ECMO","Inclusion Criteria:\n\n* Adult patient with ARDS on VV-ECMO\n\nExclusion Criteria:\n\n* Contraindication to anticoagulation with UFH (known heparin-induced thrombocytopenia, active hemorrhage, any surgery precluding the use of anticoagulation),\n* Indication for therapeutic anticoagulation (pulmonary embolism or deep vein thrombosis, chronic anticoagulation therapy before ECMO insertion)\n* Low-flow (\\\u003C2 liters\u002Fmin) VV-ECMO (ECCO2R)","ALL","18 Years",{"count":19,"type":20},40,"ESTIMATED","INTERVENTIONAL",[23,24],"PHASE2","PHASE3","Currently international experts recommend therapeutic anticoagulation for veno-venous extracorporeal membrane oxygenation (VV-ECMO). Reports and case series suggest that the absence of therapeutic anticoagulation is safe for VV-ECMO. No randomized control trials have assessed this. The aim of this pilot study is to assess safety and feasibility of an \"anticoagulation-free strategy\" for veno-venous ECMO (VV-ECMO) in Acute respiratory distress syndrome (ARDS).",[27],"Extracorporeal Membrane Oxygenation Complication",[29,30,31,32],"Extracorporeal membrane oxygenation","Anticoagulation","Thrombosis","Hemorrhage","RECRUITING","2026-01-14",{"date":36,"type":37},"2026-01-16","ACTUAL",{"date":39,"type":37},"2022-09-01",{"date":41,"type":20},"2027-01-30",{"name":43,"class":44},"Damian Ratano","OTHER",""]