[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Daniel A Tonetti, MD\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":45},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":10,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":5},"100620740",false,"NCT07361549","Localized Injection of Lidocaine Via the Middle Meningeal Artery for Intractable Headache Treatment","Localized Injection of Lidocaine Via the Middle Meningeal Artery for Intractable Headache Treatment: A Randomized, Double-Blinded, Parallel Phase 2 Clinical Trial","LIGHT 2","Inclusion Criteria:\n\n* Age 18 years or above\n* Referred for diagnostic angiography\n* Diagnosis of intractable migraine\n* Written informed consent able to be obtained from subject\n\nExclusion Criteria:\n\n* Baseline HIT-6 score less than 60 (severe)\n* Pregnant, breastfeeding, or unwilling to practice contraception during participation in the study\n* Presence of a condition or abnormality that in the opinion of the Investigator would compromise the safety of the patient or the quality of the data\n* Concomitant intracranial pathology (eg, intracranial malignancy)\n* Known hypersensitivity and\u002For contraindication to lidocaine or local anesthetics of the amide type\n* Taking chronic medications that, when co-administered with lidocaine and other local anesthetics, are at increased risk of developing methemoglobinemia (nitrates\u002Fnitrites, local anesthetics, antineoplastic agents, antibiotics, antimalarials, anticonvulsants, acetaminophen, metoclopramide, quinine, sulfasalazine)\n* Known contraindications for angiography (eg, ESRD not requiring hemodialysis). Patients with contrast allergy with be premeditated with diphenhydramine and steroids.\n* Contraindication to anesthetic agents used for conscious sedation\u002Fmonitored anesthesia care (MAC)\n* Concurrent participation in another research protocol for investigation of an experimental therapy\n* Per DSA imaging, presence of a cerebrovascular pathology known to cause headache (eg, arteriovenous malformation, dural arteriovenous fistula)\n* Per DSA imaging, presence of anastomosis or anatomical variation (eg, branches of middle meningeal artery) that could lead to increased procedural risk\n* Per DSA imaging, lack of endovascular access to either middle meningeal artery, or origin of the middle meningeal artery other than from the external carotid artery\n* Known or suspected inability to adhere to study protocol or protocol requirements, as per discretion of the Investigator or treating provider","ALL","18 Years",{"count":19,"type":20},80,"ESTIMATED","INTERVENTIONAL",[23],"PHASE2","The goal of this clinical trial is to test whether injecting lidocaine into two blood vessels of the brain can help treat chronic headaches (migraines)",[26,27],"Refractory Migraine","Headache",[29,30,31,32],"headache","migraine","lidocaine","middle meningeal artery","NOT_YET_RECRUITING","2026-01-21",{"date":36,"type":37},"2026-01-23","ACTUAL",{"date":39,"type":20},"2026-03",{"date":41,"type":20},"2031-07",{"name":43,"class":44},"Daniel A Tonetti, MD","OTHER",""]