[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"David Krpata\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":64},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,40],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":10,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":39},"100514148",false,"NCT05974722","Mesh Vs Pledgets for Repair of Paraesophageal Hernia","A Randomized, Blinded, Parallel-group Trial Evaluating Mesh Versus Pledgeted Sutures in Paraesophageal Hernia Recurrence","Inclusion Criteria:\n\n* 18 years of age or older\n* Willing and able to provide informed consent\n* Willing and able to participate in long-term follow up including study visits and surveys\n* Type II, III, or IV hiatal hernia \\> 5 cm, confirmed via upper GI studies, CT, or MRI 5 cm or greater hernia confirmed intraoperatively\n\nExclusion Criteria:\n\n* Pregnancy\n* BMI \\>45\n* Allergy to any components of mesh\n* Patients undergoing PEHR with a concurrent bariatric procedure or other procedure to reduce stomach volume (sleeve gastrectomy, roux-en-y gastric bypass, duodenal switch, single-anastomosis gastric bypass, and partial or total gastrectomy)\n* Patients who have undergone previous hiatal hernia repair","ALL","18 Years",{"count":18,"type":19},164,"ESTIMATED","INTERVENTIONAL",[22],"NA","The goal of this clinical trial is to compare whether the use of Ovitex mesh provides superior reduction in 2-year recurrence compared to pledgeted suture closure (no mesh) for patients undergoing paraesophageal hernia repair at the Cleveland Clinic. The main questions it aims to answer are:\n\n* Determine whether there is a difference in 2-year rates of radiographic recurrence with Ovitex versus pledgeted sutures in paraesophageal hernia repair.\n* Assess patient quality of life (QOL) after paraesophageal hernia repair with pledgets and mesh. A two-tailed research hypothesis will be used to determine whether there are differences between the two arms",[25,26],"Paraesophageal Hernia","GERD","RECRUITING","2025-10-02",{"date":30,"type":31},"2025-10-07","ACTUAL",{"date":33,"type":31},"2023-09-11",{"date":35,"type":19},"2028-12",{"name":37,"class":38},"David Krpata","OTHER",1,{"id":41,"slug":4,"hasResults":10,"nctId":42,"briefTitle":43,"officialTitle":44,"acronym":4,"eligibilityCriteria":45,"healthyVolunteers":46,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":47,"targetDuration":4,"studyType":20,"phases":49,"briefSummary":50,"conditions":51,"keywords":54,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":57,"startDateStruct":59,"completionDateStruct":61,"leadSponsor":63,"locationsCount":39},"100476492","NCT05484635","Mesh Removal Versus No Mesh Removal for Chronic Groin Pain After Inguinal Hernia Repair","Mesh Removal Versus No Mesh Removal for Chronic Groin Pain After Minimally Invasive Inguinal Hernia Repair: A Randomized Controlled Trial","Inclusion Criteria:\n\n* \\> 18 years of age\n* CPIP lasting \\> 6 months after laparoscopic or robotic inguinal hernia repair with pre-peritoneal mesh\n* Must exhibit 1 or more of the following characteristics of nociceptive pain:\n\nHistory:\n\n* Pain while sitting in a chair for prolonged periods of time with relief when extending the hip or lying supine to straighten the leg\n* Severe pain when crossing the affected leg over the contralateral leg\n* \"Foreign body sensation\" or \"tightness\" in the groin\n\nExam:\n\n-Diffuse tenderness with deep palpation along the inguinal ligament (over the mesh)\n\nSomatosensory mapping:\n\n* Does not have a maximum trigger point for pain\n* Lacks characteristics of neuropathic pain (sharp, burning, shooting, paresthesias, allodynia, hyperalgesia, etc.)\n\n  * Moderate to severe pain \\[4-10\\] when moving from supine to standing on NRS\n\nExclusion Criteria:\n\n* No characteristics of nociceptive groin pain\n* Zero or mild pain \\[0-3\\] when moving from supine to standing on NRS\n* Recurrent inguinal hernia detected on clinical exam\n* Large, femoral, direct or indirect inguinal hernia (F2-3, M2-3, L2-3) on diagnostic laparoscopy as defined by European Hernia Society (EHS) classification\n* Prior open (anterior) approach to inguinal hernia repair (i.e. Lichtenstein)\n* Prior mesh plugs or Prolene Hernia Systems\n* History of prostatectomy or vascular procedures in the pelvis or groin",true,{"count":48,"type":19},70,[22],"This study is evaluating the management of chronic post-operative inguinal hernia pain and the impact of hernia mesh removal after previous minimally invasive inguinal hernia repairs.\n\nThe study aims are to evaluate the change in chronic (\\>6 months), nociceptive, postoperative inguinal pain after mesh removal compared to no mesh removal in patients who have previously undergone minimally invasive inguinal hernia repair with pre-peritoneal mesh.",[52,53],"Chronic Groin Pain","Hernia, Inguinal",[55,53,56],"Chronic groin pain","Chronic pain groin",{"date":58,"type":31},"2025-10-06",{"date":60,"type":31},"2022-07-25",{"date":62,"type":19},"2028-07-01",{"name":37,"class":38},""]