[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Dr. Diane Lougheed\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":45},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":5},"100293896",false,"NCT03105843","Sensory-Mechanical Responses to Eucapneic Voluntary Hyperventilation and Mannitol","Sensory-Mechanical Responses to Eucapneic Voluntary Hyperventilation and Mannitol in Individuals With Cough Variant Asthma and Chronic Cough","Inclusion Criteria:\n\n* Individuals aged 18-65 years of age with CVA and individuals with methacholine-induced cough but normal airway sensitivity. The following definitions will be used:\n\n  1. CVA: chronic cough (≥8 weeks) is the sole or predominant symptom and positive methacholine challenge (PC20 ≤ 16 mg\u002FmL) and history of cough responding to specific asthma treatment (such as inhaled steroid or 1 week trial of bronchodilator);\n  2. Methacholine-induced cough but normal airway sensitivity: chronic cough (≥8 weeks) is the sole or predominant symptom and negative methacholine challenges (PC20 \\> 16 mg\u002FmL).\n* Individuals aged 18-65 years of age with no history of asthma or chronic cough.\n\nExclusion Criteria:\n\n* an exacerbation necessitating a change in medication, emergency department visit or hospitalizations within the previous 4 weeks\n* inability to perform acceptable spirometry\n* medical contraindications to methacholine challenge testing\n* smoking history in excess of 10 pack years Note: Previous treatment with inhaled or systemic corticosteroids is not an exclusion criterion; medication use will be recorded and examined in the analysis.",true,"ALL","18 Years","65 Years",{"count":20,"type":21},30,"ESTIMATED","INTERVENTIONAL",[24],"PHASE4","The objectives of this study are to determine the sensory-mechanical responses to Eucapneic Voluntary Hyperventilation (EVH) and Mannitol in individuals with cough variant asthma (CVA) and methacholine-induced cough with normal airway sensitivity (COUGH) and compare these responses to a control group of healthy individuals without asthma or chronic cough.\n\nWe hypothesize:\n\n1. EVH and Mannitol cause dyspnea, cough, small airway obstruction with resultant dynamic hyperinflation, gas trapping and autoPEEP in individuals with CVA and COUGH, but not healthy controls.\n2. The sensory-mechanical responses to both hyperosmolar challenges (EVH and Mannitol) are comparable within groups (CVA, COUGH and healthy controls).",[27,28,29],"Asthma","Cough","Cough Variant Asthma",[27,28,31,32],"Eucapneic Voluntary Hyperventilation","Hypertonic Saline","RECRUITING","2025-03-17",{"date":36,"type":37},"2025-03-20","ACTUAL",{"date":39,"type":37},"2022-03-01",{"date":41,"type":21},"2026-06-30",{"name":43,"class":44},"Dr. Diane Lougheed","OTHER",""]