[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Freda Patterson\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":46},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":12,"acronym":13,"eligibilityCriteria":14,"healthyVolunteers":10,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":30,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":5},"100596769",false,"NCT07049783","Examining the Circadian Timing Effects of the Hypotensive Response to Exercise","XTIME","Inclusion Criteria:\n\n* 18-39 Years old\n* Resting blood pressure greater than or equal to 120\u002F80 mmHg or less than 140\u002F90 mmHg\n\nExclusion Criteria:\n\n* Diagnosis or history of chronic or autoimmune disease (i.e., cardiovascular, metabolic, renal, endocrine, cancer)\n* Diagnosis or history of sleep disorder (i.e., obstructive sleep apnea, insomnia, restless leg syndrome)\n* Alcohol or drug dependence\n* Elevated risk for sleep disorders\n* Elevated risk for clinical depression\n* Normotensive (blood pressure less than 120\u002F80 mmHg) or stage 2+ hypertension (blood pressure greater than or equal to 140\u002F90 mmHg)\n* Body mass index less than 18.5 or greater than 35 kg\u002Fm2\n* Self-reported use of sleep medications\u002Fsupplements (e.g., melatonin)\n* Self-reported use of medications influencing vascular physiology (e.g., antihypertensive medications, weight loss medications)\n* Highly physically active (greater than or equal to 300 minutes moderate-to-vigorous physical activity per week)\n* Currently pregnant or breastfeeding\n* Current tobacco use (greater than or equal to 1 cigarette in the past month)\n* Nighttime or rotating shift work within the last 3 months\n* Contraindications to aerobic exercise","ALL","18 Years","39 Years",{"count":19,"type":20},30,"ESTIMATED","INTERVENTIONAL",[23],"NA","The goal of this study is to learn how exercise timing affects blood pressure in adults with elevated or high blood pressure. Exercise can influence the body's natural 24-hour rhythms, including blood pressure patterns. A single exercise session can lower blood pressure for up to 24 hours, but it is not fully understood how the time-of-day for exercise affects this response. The main question this study aims to answer is:\n\n• When the same participant exercises at different times of day (morning, afternoon, or evening), how does this affect the participant's blood pressure over the next 24 hours?\n\nParticipants will:\n\n* Undergo an in-lab assessment of individual biological rhythm that will indicate the clock-time for an individual's biological night\n* Complete 3 supervised treadmill exercise sessions\n\n  * 1 in the biological morning (biological night + 10 hours)\n  * 1 in the biological afternoon (biological night + 15 hours)\n  * 1 in the biological evening (biological night + 20 hours)\n* Complete a 24-hour blood pressure assessment before and after each exercise session",[26,27,28,29],"Young Adults","Hypertension","Post-Exercise Hypotension","Circadian Rhythm",[31,27,32,33],"Young adults","Post-exercise hypotension","Circadian rhythm","RECRUITING","2025-08-12",{"date":37,"type":38},"2025-08-17","ACTUAL",{"date":40,"type":38},"2025-07-22",{"date":42,"type":20},"2026-09",{"name":44,"class":45},"Freda Patterson","OTHER",""]