[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"GenieBiome Limited\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":67},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,42],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":10,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":26,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":5},"100585658",false,"NCT06905223","A Pilot Study of Synbiotics in Adults With Depressive Symptoms","A Pilot Study on the Efficacy of a Synbiotic Formula (MQU10) in Improving Mood and Well-being in Adults With Mild to Moderate Depressive Symptoms","Inclusion Criteria:\n\n* Individuals aged 18 or above\n* Patient Health Questionnaire-9 (PHQ-9) score between 5 to 14\n* Literate and can complete the self-report questionnaires\n* Able to understand the consent and sign the informed consent form\n\nExclusion Criteria:\n\n* Current diagnosis of substance abuse or dependence;\n* A current or past history of bipolar disorder, manic or hypomanic episodes, schizophrenia, personality disorder, posttraumatic stress disorder (PTSD), intellectual disability, neurodegenerative disorders (e. g, Parkinson's disease) or organic mental disorder\n* Requiring immediate psychiatric care (e. g, imminently suicidal subjects) or have attempted suicide in the past 3 months\n* Use of antipsychotics, antidepressants or sedatives, unless on a stable dose in the last 4 weeks\n* History of severe organ failure, renal failure on dialysis, HIV infection\n* Active malignancy within 5 years\n* History of major surgery on the gastrointestinal tract, except cholecystectomy and appendectomy in the past 5 years\n* Night shift work\n* History of antibiotic use within 4 weeks\n* History of allergy to probiotics or lactose leading to a severe allergic reaction\n* Known pregnancy or lactating","ALL","18 Years",{"count":18,"type":19},30,"ESTIMATED","INTERVENTIONAL",[22],"NA","This study aims to explore the efficacy and safety of a synbiotic formula (MQU10) in improving mood and well-being in adults with mild to moderate depressive symptoms.",[25],"Depressive Symptoms Mild to Moderate in Severity",[27,28,29],"Depressive symptoms","Synbiotics","Adult Mood","RECRUITING","2025-06-04",{"date":33,"type":34},"2025-06-08","ACTUAL",{"date":36,"type":34},"2025-04-03",{"date":38,"type":19},"2027-09-26",{"name":40,"class":41},"GenieBiome Limited","INDUSTRY",{"id":43,"slug":4,"hasResults":10,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":4,"eligibilityCriteria":47,"healthyVolunteers":10,"sex":48,"minAge":16,"maxAge":49,"enrollmentInfo":50,"targetDuration":4,"studyType":20,"phases":52,"briefSummary":53,"conditions":54,"keywords":57,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":64,"leadSponsor":66,"locationsCount":5},"100559150","NCT06560385","Alleviation of Alopecia in Breast Cancer Patient Using Synbiotics Formula","A Pilot, Double-blind, Randomised, Placebo-controlled Trial on the Efficacy of a Synbiotic Formula (BLHK03) in Alleviating Chemotherapy-induced Alopecia (CIA) in Breast Cancer Patients","Inclusion Criteria:\n\n* Females aged between 18 and 60 years who are newly diagnosed with stage I, II or III breast cancer\n* Planned chemotherapy including an anthracycline or taxane to be completed within 6 months\n* Mentally capable to participate in the study and provide informed consent\n\nExclusion Criteria:\n\n* Pre-existing female-pattern baldness resembling picture I-3 or higher on the Savin scale at baseline\n* History of hair transplantation, psoriasis or severe scalp infection\n* Undergoing or plan to receive scalp cooling\n* Plan for immunotherapy\n* Known pregnancy or lactating\n* Severe cardiac, hepatic, renal, pulmonary and haematic lesions or other life-threatening conditions\n* Use of antibiotics, probiotics or prebiotics one month prior to enrolment\n* No other alternative or complementary treatment for the cancer condition that may affect the gut microbiome analysis\n* History of allergy to probiotics or lactose\n* History of chemotherapy for other conditions","FEMALE","60 Years",{"count":51,"type":19},40,[22],"This study aims to explore the efficacy and safety of a synbiotic formula (BLHK03) in alleviating chemotherapy-induced alopecia (CIA) in breast cancer patients and the compositional and functional changes in the gut microbiome of breast cancer patients undergoing chemotherapy and treatment with BLHK03.",[55,56],"Breast Cancer","Hair Loss",[55,56,58,59],"Chemotherapy","Synbiotic","2024-09-11",{"date":62,"type":34},"2024-09-19",{"date":60,"type":34},{"date":65,"type":19},"2026-08-18",{"name":40,"class":41},""]