[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Hospital Municipal Pedro T. Orellana\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":43},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":10,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":27,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":5},"100573389",false,"NCT06745648","Carotid Sinus Massage in Trendelenburg Position for Headache Relief","Effectiveness of Carotid Sinus Massage in Modified Trendelenburg Position for Acute Headache Episodes: A Pilot Study","INCLUSION CRITERIA:\n\n* Participants must be at least 16 years of age.\n* Must have a diagnosis of one of the following, according to the International Classification of Headache Disorders (ICHD-3):\n\n  * Migraine\n  * Tension-type headache\n  * Mixed headache\n* The headache episode must have started within the past 24 hours.\n\nEXCLUSION CRITERIA:\n\n* Any contraindication to carotid sinus massage, including:\n\n  * Carotid bruits\n  * Recent myocardial infarction\n  * History of stroke\n  * Known or suspected carotid artery stenosis\n* Any contraindication to the Trendelenburg position, including:\n\n  * Increased intracranial pressure\n  * Respiratory distress\n  * Congestive heart failure\n  * History of syncope\n  * History of cardiac arrhythmias","ALL","16 Years",{"count":18,"type":19},18,"ESTIMATED","INTERVENTIONAL",[22],"NA","Headaches significantly impact patients' quality of life, with tension-type headaches and migraines being among the most prevalent types. There is growing evidence suggesting that blood pressure regulation and baroreceptor activity play a role in headache pathophysiology. Carotid sinus massage (CSM), particularly when combined with the modified Trendelenburg position, may modulate autonomic nervous system activity to relieve headache symptoms.\n\nAn initial open-label pilot study (n = 17) was completed, and the results were published in a preprint server for health sciences, the Medical Research Archive (medRxiv), demonstrating the feasibility, safety, and promising preliminary efficacy of CSM+T. Based on these findings, a follow-up randomized, sham-controlled, parallel-arm trial will further evaluate the efficacy of the treatment.",[25,26],"Migraine","Tension-Type Headache",[28,29,30],"Carotid Sinus Massage","Trendelenburg","Autonomic Nervous System","RECRUITING","2025-06-11",{"date":34,"type":35},"2025-06-15","ACTUAL",{"date":37,"type":35},"2024-12-21",{"date":39,"type":19},"2025-12-30",{"name":41,"class":42},"Hospital Municipal Pedro T. Orellana","OTHER",""]