[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Hospital del Mar Research Institute (IMIM)\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":42},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":10,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":25,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":37,"leadSponsor":39,"locationsCount":5},"100643705",false,"NCT07607080","Predicting High-Flow Nasal Cannula Failure in Acute Hypoxemic Respiratory Failure Using Metabolomics and Clinical Data","Metabolomics and Clinical Data to Predict High-Flow Nasal Cannula Failure and Optimize Respiratory Support in Acute Hypoxemic Respiratory Failure","META-RESPIRE","Inclusion Criteria:\n\n* Adult patients (≥18 years old).\n* Admission to the intensive care unit (ICU) with acute hypoxemic respiratory failure (AHRF).\n* Treatment with high-flow nasal cannula (HFNC) as the initial respiratory support strategy.\n* Inclusion within the first 24 hours after HFNC initiation.\n* Provision of informed consent by the patient or legally authorized representative.\n\nExclusion Criteria:\n\n* Age \\\u003C18 years.\n* Active do-not-resuscitate (DNR) orders or limitation of therapeutic effort.\n* Refusal or inability to provide informed consent.\n* Previous invasive mechanical ventilation before study inclusion.","ALL","18 Years",{"count":19,"type":20},300,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to determine whether metabolomic profiles combined with clinical data can predict high-flow nasal cannula (HFNC) failure and help optimize respiratory support in adult patients with acute hypoxemic respiratory failure (AHRF). The main questions it aims to answer are:\n\nCan metabolomic biomarkers identify patients at higher risk of HFNC failure? Does combining metabolomic and clinical data improve the prediction of respiratory support escalation and clinical outcomes?\n\nParticipants will:\n\nReceive standard HFNC treatment according to clinical practice. Undergo collection of clinical, physiological, and laboratory data. Provide blood samples for metabolomic analysis during respiratory support.",[24],"Acute Hypoxemic Respiratory Failure",[26,27,28,29,30],"Acute Hypoxemic Respiratory Failure (AHRF)","High-Flow Nasal Cannula (HFNC)","Metabolomics","Respiratory Failure Prediction","Noninvasive Respiratory Support","RECRUITING","2026-06-04",{"date":34,"type":35},"2026-06-08","ACTUAL",{"date":32,"type":35},{"date":38,"type":20},"2029-05",{"name":40,"class":41},"Hospital del Mar Research Institute (IMIM)","OTHER",""]