[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Institute for Human Development and Potential (IHDP), Singapore\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":192},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,50,79,111,141,167],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":34,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100630118",false,"NCT07483515","Bonding Before Birth: A mHealth Intervention for First-time Expectant Couples","Bonding Before Birth: A Cluster-randomized, Controlled, mHealth Trial for Developing Mindfulness and Emotional Regulation in Expectant Couples","B³","Inclusion Criteria:\n\nMothers:\n\n1. 21-50 years of age\n2. Less than 20 weeks of pregnancy, confirmed by ultrasonography upon enrolment\n3. Singleton pregnancy\n4. Nulliparous\n5. Plan to deliver in Singapore\n6. Proficient and able to respond to questionnaires in English\n7. Intends for herself and her child to stay in Singapore for the next 2 years\n8. Access to a smartphone\n9. Willing to download the study app\n10. Score of 7 or more in the Edinburgh Postnatal Depression Scale\n\nFathers:\n\n1. 21-75 years of age\n2. Proficient and able to respond to questionnaires in English\n3. Intends for himself and his child to stay in Singapore for the next 2 years\n4. Access to a smartphone\n5. Willing to download the study app\n\nExclusion Criteria:\n\nMothers:\n\n1. Any pre-existing or history of psychotic depression, schizophrenia, and bipolar disorders\n2. Currently on oral\u002FIV steroids and\u002For thyroid medication\n3. History of thyroid disease\n4. Pregnant using assisted reproductive technologies\n5. Multiple pregnancies\n6. Currently enrolled in interventional randomised controlled trials\n7. Responded \"Yes, quite often\" to EPDS item 10 (\"The thought of harming myself has occurred to me\")\n\nFathers:\n\n1\\. Currently enrolled in interventional randomised controlled trials",true,"ALL","21 Years","75 Years",{"count":21,"type":22},572,"ESTIMATED","INTERVENTIONAL",[25],"NA","Emotional regulation is a key component of reducing parenting stress, a sense of self-efficacy, and thus successful parenting, child outcomes, and productivity amongst working parents. However, few interventions begin building these necessary components in pregnancy prior to the extremely stressful period immediately post-partum, where little trait and behavioural modification occurs. More importantly, most interventions overlook the importance of having both partners, despite fathers\u002Fpartners playing a significant role in influencing maternal stress and mood symptoms.\n\nThis goal of this study is to examine whether short weekly exercises delivered through a mobile app can help first-time parents feel better emotionally during pregnancy. These exercises are designed to help people manage their emotions and stress. Researchers want to know if doing these exercises, along with getting weekly feedback and encouragement, can reduce signs of depression and improve emotional control.\n\nExpecting mothers and fathers who are having their first child may be able to join the study if they meet certain conditions. Participants should be planning to stay in Singapore for the next two years and be comfortable using a smartphone and answering questions in English. Participants may benefit from learning new ways to manage stress and emotions, which could help improve their mental health.\n\nParticipants will wear a Fitbit watch to track activity. They will complete a short weekly survey about their well-being during pregnancy and a monthly survey about their work productivity until six months after the baby is born. They will also answer online surveys about their health, relationships, and background at the start, three times during pregnancy, and three times after birth. In addition, they will visit the research lab twice to take part in tasks that measure thinking and behaviour.",[28,29,30,31,32,33],"Anxiety","Pregnancy","Parenting Self-efficacy","Stress (Psychology)","Depression","Emotion Regulation",[35,36,33,32,29,28],"Reinforcement Learning","Micro-randomization","RECRUITING","2026-06-28",{"date":40,"type":41},"2026-06-30","ACTUAL",{"date":43,"type":22},"2026-07-06",{"date":45,"type":22},"2028-12-31",{"name":47,"class":48},"Institute for Human Development and Potential (IHDP), Singapore","OTHER",1,{"id":51,"slug":4,"hasResults":10,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":10,"sex":17,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":4,"studyType":23,"phases":61,"briefSummary":62,"conditions":63,"keywords":65,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":4},"100644451","NCT07663123","Health Assessment of Low Glycaemic Index - High Protein Rice to Enhance Glycemic Control Through Nutrition","Health Assessment of Low Glycaemic Index - High Protein Rice to Enhance Glycemic Control Through Nutrition (HARVEST) Study","HARVEST","Inclusion Criteria:\n\n1. Males or females, aged 40 to 65 years old\n2. Chinese, Malay or Indian\n3. Body Mass Index between 23.0 - 32.0 kg\u002Fm2\n4. Prediabetes profile as per fasting plasma glucose (≤ 6.9 mmol\u002FL) and HbA1c level (5.7% - 6.4%)\n5. Habitually consuming about 3 to 5 servings of polished white rice per day\n6. No known food allergies and intolerance to food provided as part of study procedures\n7. Proficient in English language\n8. Willing to comply to study procedures and provide written consent\n\nExclusion Criteria:\n\n1. Diagnosed with Type 1 or 2 diabetes mellitus\u002F OGTT failure during screening visit\n2. History or current diagnosis of cardiovascular, endocrine, gastrointestinal, haematological, hepatitis (hepatitis B and C), cancers (except basal cell carcinoma), chronic kidney disease or other medical conditions which may affect study outcomes, as assessed by study team\n3. Having chronic medication (eg: metformin, oral corticosteroids etc), and\u002For supplements that may influence glycaemic management and other study outcomes, as assessed by study team\n4. History of bariatric surgery\n5. Significant weight change (± 5 % body weight) during the last 3 months\n6. Women who are pregnant, breastfeeding or planning pregnancy\n7. Drug abuse within the last 5 years\n8. Excessive alcohol consumption \\> 2 servings per day\n9. Smoking in the last 1 year\n10. Following any special diet(s) which may interfere with study outcomes (eg: Ketogenic diet, intermittent fasting, calorie-deficit)\n11. Major change in physical activity and\u002For dietary habits in the last 3 months\n12. Use of oral antibiotics in the last 3 months\n13. Participation in other intervention studies, which may affect study outcomes as assessed by study team\n14. Staff of IHDP and SIFBI in A\\*STAR","40 Years","65 Years",{"count":60,"type":22},225,[25],"Type 2 Diabetes (T2D) represents a critical public health challenge in Singapore, with prevalence projected to reach one million residents by 2050. This epidemic is largely driven by a distinct \"Asian phenotype\" characterized by reduced insulin secretion capacity even at lower BMIs and a diet heavily centered on high-glycemic index (GI) white rice. While brown rice offers superior nutritional benefits, its global and local adoption remains low due to entrenched cultural preferences, shorter shelf life, and sensory barriers.\n\nWhile the link between high-GI carbohydrates and metabolic dysfunction is well-documented, there is limited clinical evidence on the effects of \"functional\" white rice varieties specifically those engineered to combine low GI properties with significantly enhanced protein content on long-term glycemic control, metabolic and gut microbiome health in Asian populations. The importance of this research lies in its evaluation of a culturally seamless substitution strategy. By replacing conventional white rice with Low-GI (LGI) and High-Protein Low-GI (LGI-HP) varieties, the HARVEST study addresses the metabolic burden of prediabetes without requiring major behavioral shifts. The findings will provide vital mechanistic insights into glucose regulation, insulin sensitivity, and microbial dysbiosis, to provide the evidence based for nutritional strategies for T2D prevention and management.",[64],"Prediabetes \u002F Type 2 Diabetes",[66,67,68,69],"Prediabetes","Type 2 Diabetes prevention","Nutrition","Metabolic dysfunction","NOT_YET_RECRUITING","2026-06-17",{"date":73,"type":41},"2026-06-23",{"date":75,"type":22},"2026-08-10",{"date":77,"type":22},"2029-04-30",{"name":47,"class":48},{"id":80,"slug":4,"hasResults":10,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":84,"eligibilityCriteria":85,"healthyVolunteers":16,"sex":17,"minAge":86,"maxAge":4,"enrollmentInfo":87,"targetDuration":4,"studyType":23,"phases":89,"briefSummary":90,"conditions":91,"keywords":94,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":49},"100635750","NCT07556744","SOMA Validation RCT: Testing Structural Equivalence and Mechanistic Orthogonality of an Open-Source Mindfulness Stimulus Library","The Standardized Open-source Mindfulness Architecture (SOMA): A Modular, Equity-Engineered Stimulus Library for Mechanistic Mindfulness Research","SOMA-VAL","Inclusion Criteria:\n\nAged 18 years or older (or the legal age of majority in the participant's country of residence, whichever is higher)\n\nFluent in English (English as first language or self-reported fluent language)\n\nAble to listen to a 12-minute audio recording with headphones, earphones, or device speaker\n\nAccess to a device capable of completing an online survey\n\nExclusion Criteria:\n\nCurrent diagnosis of a mental health condition\n\nCurrently receiving or waiting for treatment for mental health symptoms (e.g., psychological therapy or psychiatric medication)\n\nRegular yoga or meditation practice in the last six months","18 Years",{"count":88,"type":22},360,[25],"Background: Mindfulness research faces two structural problems. First, weak active control conditions make it impossible to isolate specific mechanisms from expectancy and non-specific effects. Second, most protocols systematically exclude low-socioeconomic status (SES) populations through design assumptions that presuppose high literacy, quiet private spaces, and familiarity with contemplative practice.\n\nObjective: This study validates the Standardized Open-source Mindfulness Architecture (SOMA), the first modular, open-source stimulus library purpose-built to address both challenges simultaneously. SOMA comprises 88 distinct audio assets organized around 16 sensory practice modules, each paired with a structurally equivalent active control script engineered to induce analytically orthogonal cognitive processing.\n\nDesign: Pre-registered randomized controlled trial using a 2×2 mixed design (Condition \\[Mindfulness vs. Active Control\\] × Measure \\[State Mindfulness Scale vs. Analytical Engagement Scale\\]), with quota sampling to ensure equal representation of participants with and without a university-level degree (n = 180 per SES stratum).\n\nSetting: Online, via Prolific Academic recruitment platform and Qualtrics survey software.\n\nParticipants: N = 360 English-proficient adults aged 18 years and older (or the applicable minimum age of majority in the participant's country of residence) without a current mental health diagnosis or treatment, and without a current meditation practice.\n\nIntervention: Each participant listens to a single 12-minute audio-guided exercise. Participants are randomly assigned to either the Mindfulness condition or the Active Control condition, and within that condition to one of 16 practice scripts. Mindfulness scripts guide bottom-up experiential awareness; Active Control scripts guide top-down analytical processing of the same everyday activities.\n\nPrimary Outcomes: (1) Credibility and expectancy equivalence between conditions (H1: Two One-Sided Tests on Credibility and Expectancy Questionnaire composite, equivalence bounds d = ±0.40); (2) mechanistic double dissociation - higher state mindfulness in the Mindfulness condition and higher analytical engagement in the Active Control condition (H2: 2×2 mixed ANOVA, interaction term as primary criterion).\n\nExploratory Outcome: SES-related differential experiential accessibility (H3: independent-samples t-test plus equivalence test on Semantic Differential composite by SES group).",[92,93],"Mindfulness","Healthy Volunteers",[92,95,96,97,98,99,100,101,102],"Active Control","Stimulus Library","Mechanistic Research","Open Science","Socioeconomic Status","Credibility","Expectancy","Randomized Controlled Trial","2026-04-28",{"date":105,"type":41},"2026-05-04",{"date":107,"type":22},"2026-05-05",{"date":109,"type":22},"2026-05-31",{"name":47,"class":48},{"id":112,"slug":4,"hasResults":10,"nctId":113,"briefTitle":114,"officialTitle":114,"acronym":4,"eligibilityCriteria":115,"healthyVolunteers":16,"sex":116,"minAge":57,"maxAge":117,"enrollmentInfo":118,"targetDuration":4,"studyType":23,"phases":120,"briefSummary":121,"conditions":122,"keywords":127,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":133,"lastUpdatePostDateStruct":134,"startDateStruct":136,"completionDateStruct":138,"leadSponsor":140,"locationsCount":49},"100626239","NCT07433049","Impact of Supplementation in Improving Metabolic Health Outcomes (ISMOS) Study","Inclusion Criteria:\n\n* Women aged 40-60 years old\n* Chinese, Malay or Indian\n* BMI between 23.0-35.0 kg\u002Fm2\n* Proficient in English language\n* Willing to comply with study protocol \\& provide informed consent\n\nExclusion Criteria:\n\n* Pregnant or planning a pregnancy\n* Diagnosis with Diabetes, Polycystic Ovary Syndrome (PCOS), autoimmune diseases, chronic organ failure, severe heart disease, eating disorders and\u002For other medical conditions which in the PI's judgment which may affect study outcomes\n* Fasting glucose value ≥ 7.0 mmol\u002FL\n* Active cancer or treatment of cancer in the last 3 years\n* Participating in other nutritional intervention studies\n* Taking oral corticosteroids, anti-psychotic and\u002For weight loss drugs\n* Having planned hospitalization in the next 12 months\n* Planning to have major diet changes in the next 12 months\n* Taking a medically prescribed supplement(s) that contains 3 or more of the ingredients of the study product\n* Taking a non-prescribed supplement(s) that contains 3 or more of the ingredients of the study product in the last 1 month","FEMALE","60 Years",{"count":119,"type":22},400,[25],"This study investigates the role of multivitamin and multimineral (MVM) supplementation in improving metabolic, musculoskeletal, and mental health among midlife Asian women aged 40-60 years, a critical period marked by hormonal and physiological transitions from pre- to post-menopause. Evidence from the GUSTO cohort in Singapore has shown that higher plasma levels of vitamins B6, B9, B12, and D are associated with better metabolic profiles, insulin sensitivity, and mental wellbeing, while deficiencies are linked to increased metabolic and psychological risks. Given that vitamin insufficiency and central obesity are highly prevalent among Asian women even at lower BMI, this randomized, double-blind, placebo-controlled trial will evaluate whether 12 months of daily MVM supplementation can reduce MetaboAge and improve metabolic, mental, and muscle health outcomes compared with placebo. Findings will inform preventive strategies for extending health span and mitigating chronic disease risks among midlife women in Asia.",[123,124,125,126],"Glucose Control","Mental Health","Musculoskeletal Health","Body Composition",[128,129,130,131,132],"Multivitamin and mineral supplementation","Women","Metabolic health","Mental health","Muscle health","2026-02-19",{"date":135,"type":41},"2026-02-25",{"date":137,"type":41},"2026-01-20",{"date":139,"type":22},"2028-01",{"name":47,"class":48},{"id":142,"slug":4,"hasResults":10,"nctId":143,"briefTitle":144,"officialTitle":145,"acronym":146,"eligibilityCriteria":147,"healthyVolunteers":16,"sex":17,"minAge":148,"maxAge":149,"enrollmentInfo":150,"targetDuration":4,"studyType":152,"phases":4,"briefSummary":153,"conditions":154,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":158,"lastUpdatePostDateStruct":159,"startDateStruct":161,"completionDateStruct":163,"leadSponsor":165,"locationsCount":166},"100563939","NCT06622681","Integrative Adolescence Research Programme (IARP)","Integrative Adolescence Research Programme (IARP) - iAdoRe Study","IARP","Inclusion Criteria:\n\n1. Aged 13 to 15 years of age\n2. Currently studying in MOE registered school\n3. Part of the DREAMS study\n\nExclusion Criteria:\n\n1. Not in MOE registered school\n2. Not part of the DREAMS study","13 Years","15 Years",{"count":151,"type":22},1200,"OBSERVATIONAL","This study aims to understand child health during adolescence. We will examine the role of lifestyle (e.g. physical activity), growth trajectories and other environmental factors that can influence the development of phenotypes in adolescence which confer risk for later physical and mental disorders. With this study, we will develop a deeper understanding of adolescent health and well-being and their main determinants in the local Singaporean context, identify levers for early interventions to mitigate challenges to adolescent health and well-being and enhance protective factors for adolescents to do well in life, contribute to society and maximize their potential.",[155,156,157],"Executive Dysfunction","Physical Stress","Mental Health Wellness 1","2025-12-22",{"date":160,"type":41},"2025-12-30",{"date":162,"type":41},"2024-05-21",{"date":164,"type":22},"2026-12",{"name":47,"class":48},2,{"id":168,"slug":4,"hasResults":10,"nctId":169,"briefTitle":170,"officialTitle":171,"acronym":172,"eligibilityCriteria":173,"healthyVolunteers":16,"sex":116,"minAge":57,"maxAge":174,"enrollmentInfo":175,"targetDuration":4,"studyType":152,"phases":4,"briefSummary":176,"conditions":177,"keywords":179,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":184,"lastUpdatePostDateStruct":185,"startDateStruct":187,"completionDateStruct":189,"leadSponsor":191,"locationsCount":4},"100600680","NCT07100639","Singapore Population Research on Integrated exposoMe & Early Menopause","From Exposome to Health Outcomes: A Population-Based Approach to Understanding and Mitigating Early Menopause in Singapore's Diverse Communities","SG-PRIME","Inclusion Criteria:\n\nFemale participants aged 40-50 years No menstruation for the last 2 months or irregular menstrual cycles in the last 6 months Chinese, Malay, or Indian ethnicity Proficient in English language Planning to reside in Singapore for next 2 years Willing to provide informed consent and comply with study procedures\n\nExclusion Criteria:\n\nIn menopause (12 consecutive months without menstruation) Currently pregnant or planning to conceive History of bilateral oophorectomy and\u002For hysterectomy Currently receiving hormone therapy, including estradiol replacement therapy or oral contraceptives Diagnosed with premature ovarian insufficiency before 40 years of age Diagnosis of autoimmune conditions and\u002For chromosomal abnormalities known to affect ovarian function Diagnosis of severe cognitive impairment and\u002For mental disorders Received cancer treatment in the past 12 months","50 Years",{"count":119,"type":22},"Brief Summary\n\nThe goal of this observational study is to learn how environmental factors, lifestyle choices, and social conditions affect the timing of menopause in Asian women aged 40-50 years living in Singapore. The main aims of the project are the following:\n\n* Do environmental pollutants and lifestyle exposures contribute to earlier menopause in Asian women?\n* What biological changes occur when women are exposed to harmful environmental factors during menopause transition?\n\nParticipants will be followed for 18 months and will complete questionnaires about their health history, lifestyle, diet, and environmental exposures. Participants will provide blood, urine, stool, hair, and nail samples for laboratory analysis and undergo basic health assessments including weight, blood pressure, and bone density measurements. Participants will wear activity monitors and air pollution sensors for 7 days and attend follow-up visits at 6 months, 12 months, and 18 months to track changes in their health. This data will be obtained during the baseline visit.",[178],"Early Menopause",[180,181,182,183],"early menopause","environment","pollution","exposome","2025-07-27",{"date":186,"type":41},"2025-08-03",{"date":188,"type":22},"2025-08-06",{"date":190,"type":22},"2028-04-01",{"name":47,"class":48},""]