[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Instituto Politécnico de Bragança\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":45},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":12,"acronym":13,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":4},"100623951",false,"NCT07403305","The Effect of Water Physical Exercise Program in Thermal Water and Hydropinotherapy on Cardiovascular Health","WPEPH","Inclusion Criteria:\n\n* Men or women\n* Age: \\>45 years\n* Written informed consent prior to participation\n* Physical condition suitable for participating in physical exercise activities\n* Controlled health conditions\n\nExclusion Criteria:\n\n* History of chronic or severe diseases that may affect study outcomes or limit study participation, such as:\n* Decompensated cardiovascular disease, renal insufficiency, or severe liver disease\n* Conditions preventing the ability in physical activity (e.g., severe respiratory issues, reduced mobility, severe arthritis)\n* Severe psychiatric or cognitive disorders that could affect comprehension or adherence to the study\n* Use of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) or corticosteroids\n* Pregnancy or lactation\n* Less than 80% attendance at the 16-week aquatic exercise program",true,"ALL","45 Years",{"count":19,"type":20},80,"ESTIMATED","INTERVENTIONAL",[23],"NA","The goal of this randomized four-arm clinical trial is to determine the effect of 16-week water physical exercise program in thermal water and hydroponotherapy on lipide profile in middle-aged and elderly people, with controlled health conditions.\n\nParticipants will be randomizate into four arms:\n\n* Arm I: Control\n* Arm II: Water Physical Exercise Program (WPEP) in thermal water\n* Arm III: Hydropinotherapy with thermal water combined with bay leaf (L. nobilis)\n* Arm IV: WPEP in thermal water and hydropinotherapy with thermal water combined with bay leaf (L. nobilis)\n\nPrimary outcome:\n\n1. Lipid profile (cholesterol total, low-density lipoprotein cholesterol (c-LDL), high-density lipoprotein cholesterol (c-HDL), triglycerides)\n\n   Secondary parameters:\n2. Inflammatory biomarkers: interleukin-6 (IL-6), C-reactive protein (CRP)\n3. Glucose metabolisc: fasting plasma glucose, insulin, Hemoglobin A1c (HbA1c)\n4. Aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase, bilirubin, creatinine.\n5. Anthropometric and clinical variables: weight, waist to hip ratio, body composition and bone mineral density\n6. Systolic and diastolic blood pressure\n7. Physical function\n8. Lifestyle parameters: sleep quality, quality of life and eating habits",[26],"Cardiovascular (CV) Risk",[28,29,30,31,32],"Thermal Water","Water Exercise","Hydropinotherapy","Lipid Profile","Cardiovascular Health","NOT_YET_RECRUITING","2026-02-04",{"date":36,"type":37},"2026-02-11","ACTUAL",{"date":39,"type":20},"2026-01-19",{"date":41,"type":20},"2026-10-31",{"name":43,"class":44},"Instituto Politécnico de Bragança","OTHER",""]