[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"John O'Brien, MD\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":43},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":5},"100458204",false,"NCT05246579","Prospective Evaluation of Pathways for Preterm Birth","Prospective Evaluation of Pathways for Preterm Birth: The PEPP Study","PEPP","Inclusion Criteria:\n\n* Maternal age from 18 to 45 years of age.\n* Singleton gestation.\n\nExclusion Criteria:\n\n* Treatment with vaginal progesterone or intramuscular progestogen within the previous 4 weeks.\n* History of congestive heart failure, chronic renal failure, or uncontrolled diabetes mellitus, or diabetes mellitus with evidence of end organ dysfunction secondary to vascular disease.\n* Current pregnancy with a major fetal anomaly or known chromosomal abnormality.\n* The subject has a marked uterine anatomic malformation that may alter pregnancy duration such as a septated uterus, unicornuate uterus, or uterine didelphys.\n* The subject is considered not capable or unwilling to undergo study procedures and requirements.\n* The subject is symptomatic with vaginal bleeding at enrollment visit.",true,"FEMALE","18 Years","45 Years",{"count":21,"type":22},240,"ESTIMATED","OBSERVATIONAL","This is a single center, prospective cohort study of pregnant patients at high risk for spontaneous preterm birth: patient's with history of spontaneous preterm birth, patient's with a short cervix and patient's symptomatic for preterm birth will be included. A control cohort of nulliparous patients without a short cervix will be recruited to provide baseline data. Plan to enroll 240 patients identified through our ultrasound unit with goal of 60 patients in each group.",[26,27],"Preterm Birth","Cervix; Pregnancy",[29,26,30],"Cervical Length","Inflammation","RECRUITING","2025-06-27",{"date":34,"type":35},"2025-07-02","ACTUAL",{"date":37,"type":35},"2022-02-04",{"date":39,"type":22},"2026-06-01",{"name":41,"class":42},"John O'Brien, MD","OTHER",""]