[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Ling Zhiqiang\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":40},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":10,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":5},"100633291",false,"NCT07524777","Ganoderma Spores Modulate the Gut-Brain Axis","Targeting the Gut-Brain Axis With Ganoderma Lucidum Spores Ameliorates Depression in Thyroid Cancer Patients: a Randomized, Double-blind, Placebo-controlled Trial","Inclusion Criteria:\n\n* Outpatients at Zhejiang Cancer Hospital with histologically confirmed papillary thyroid carcinoma (post-surgery) and depressive symptoms (HAMD-24 score ≥ 8, confirmed by a clinical psychologist).\n* Han Chinese ethnicity.\n* No history of depression or other psychiatric disorders.\n* Age 18-80 years.\n* Female.\n\nExclusion Criteria:\n\n* Suffering from other gastrointestinal system diseases.\n* History of gastrointestinal surgery prior to intervention.\n* Including those with other concurrent malignancies requiring chemotherapy, radiotherapy, biological therapy, or traditional Chinese medicine treatment.\n* Received antibiotic treatment or microecological modulators within 3 months prior to intervention.\n* Acute intestinal obstruction.\n* Patients who are currently taking antidepressant medication, or those whom the investigators judge require immediate initiation of antidepressant medication treatment.\n* Organic brain diseases, brain trauma.\n* History of psychiatric disorders, use of psychoactive substances (e.g., drugs).\n* Severe liver or kidney dysfunction.\n* Pregnancy or lactation.","FEMALE","18 Years","80 Years",{"count":19,"type":20},300,"ESTIMATED","INTERVENTIONAL",[23],"NA","This study aims to investigate whether Sporoderm-removed Ganoderma lucidum spore powder (RGLS) ameliorates depression in thyroid cancer patients through gut-brain axis modulation, and to elucidate the underlying microbial and metabolic mechanisms. This 3-month randomized, double-blind, placebo-controlled trial will enroll 300 postoperative papillary thyroid carcinoma patients with depressive symptoms (HAMD-24 ≥ 8). Participants will be randomly assigned(2 : 1) to receive RGLS (4 g\u002Fday) or matched placebo.",[26,27],"Depression","Thyroid Cancer","RECRUITING","2026-05-07",{"date":31,"type":32},"2026-05-12","ACTUAL",{"date":34,"type":32},"2026-04-11",{"date":36,"type":20},"2026-08-31",{"name":38,"class":39},"Ling Zhiqiang","OTHER",""]