[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Marwan El Mobadder\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":47},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":10,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":26,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":5},"100629407",false,"NCT07474272","Non-Surgical Treatment of Periodontitis With Adjunctive Sodium Hypochlorite\u002FAmino Acids and Cross-Linked Hyaluronic Acid","Non-Surgical Treatment of Periodontitis With Adjunctive Sodium Hypochlorite \u002FAmino Acids and Cross-Linked Hyaluronic Acid: Randomized Controlled Trial","Inclusion Criteria:\n\n* Localized periodontal pocket with a probing depth ≥ 6 mm and a clinical - attachment loss of \\> 3 mm (periodontitis stage III or IV; classification of the European Federation of Periodontology and American Academy of Periodontology);\n* Patients who signed the written informed consent and is willing to cooperate;\n* Bleeding on probing in more than 30% of the sites.\n\nExclusion Criteria:\n\n* Medical history likely to affect periodontal status and\u002For to compromise treatment outcomes;\n* Patients who received antibiotic and\u002For anti-inflammatory treatments the last 6 months\n* Patients who received immunosuppressors treatments the last 6 months;\n* Patients who received any periodontal therapy for the last 6 months;\n* Pregnant or lactating women;\n* Smokers smoking more than 10 cigarettes per day.","ALL","16 Years",{"count":18,"type":19},78,"ESTIMATED","INTERVENTIONAL",[22],"NA","The goal of this clinical trial is to learn if using sodium hypochlorite\u002Famino acid gel, with or without cross-linked hyaluronic acid, as an addition to standard non-surgical periodontal therapy works to treat periodontitis in adults. It will also learn about the safety of these treatments. The main questions it aims to answer are:\n\nDoes the adjunctive treatment reduce bleeding on probing, plaque index, and periodontal pocket depth?\n\nWhat medical or dental problems do participants have when receiving these treatments?\n\nResearchers will compare:\n\nStandard non-surgical periodontal therapy alone\n\nStandard therapy plus sodium hypochlorite\u002Famino acid gel\n\nStandard therapy plus sodium hypochlorite\u002Famino acid gel and cross-linked hyaluronic acid (\"Clean and Seal\" protocol)\n\nParticipants will:\n\nReceive their assigned treatment during one clinical session per the study protocol\n\nHave clinical measurements taken before treatment and at three months after treatment\n\nBe monitored for any dental or medical adverse events related to the procedures",[25],"Periodontitis",[27,28,29,30,31,32,33,34],"periodontal pocket","periodontitis","periodontal disease","deep periodontal pocket","localized periodontitis","generalized periodontitis","non-surgical treatment of periodontitis","non-surgical periodontal treatment","NOT_YET_RECRUITING","2026-03-14",{"date":38,"type":39},"2026-03-17","ACTUAL",{"date":41,"type":19},"2026-03-11",{"date":43,"type":19},"2026-08",{"name":45,"class":46},"Marwan El Mobadder","OTHER",""]