[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Matteo Clavarezza\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":43},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":10,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":26,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":5},"100580721",false,"NCT06840977","COLON ERDERLY LOW DOSE","RETROSPECTIVE OBSERVATIONAL STUDY OF CHEMOTHERAPY IN ELDERLY PATIENTS IN THE FIRST-LINE TREATMENT OF METASTATIC COLORECTAL CANCER","CELOW","Inclusion Criteria:\n\n1. Patients with metastatic colorectal adenocarcinoma not treated with any therapy in the metastatic phase. Previous (neo)-adjuvant treatment with fluoroderivatives with or without Oxaliplatin is permitted.\n2. Age ≥ 70 years\n3. G8 score ≥ 12\n4. Patients with colorectal adenocarcinoma MSS\n5. Patients with BRAF WT colorectal adenocarcinoma\n6. Ability to understand and sign the informed consent form.\n\nExclusion Criteria:\n\n1. Patients with MSI tumours\n2. Patients with BRAF V600E mutated tumours\n3. Patients not eligible for doublet chemotherapy by clinical decision","ALL","70 Years","99 Years",{"count":20,"type":21},51,"ESTIMATED","OBSERVATIONAL","In this retrospective observational study, the case series of patients undergoing first-line treatment for metastatic colorectal adenocarcinoma with doublet fixed-dose and reduced-dose chemotherapy in combination with full-dose monoclonal antibody in patients aged 70 years or older is collected.",[25],"Colon Adenocarcinoma",[27,28,29,30],"metastatic colorectal adenocarcinom","low doses","chemotherapy","monoclonal antibodies","NOT_YET_RECRUITING","2026-01-30",{"date":34,"type":35},"2026-02-02","ACTUAL",{"date":37,"type":21},"2026-02-01",{"date":39,"type":21},"2026-07-31",{"name":41,"class":42},"Matteo Clavarezza","OTHER",""]