[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Maximilian Pfau\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":39},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":12,"acronym":13,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":25,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":5},"100632579",false,"NCT07515521","Enhanced Vision and Imaging Tests for Enabling Treatment Trials in Early and Intermediate AMD","EVITE-AMD","Inclusion Criteria:\n\n* Written informed consent.\n* All biological sexes and gender identities.\n* Age \\>=18 years for healthy volunteers; age \\>=55 years for participants with AMD.\n* Ability to understand German or English sufficiently for study information and procedures.\n\nAdditional Inclusion Criteria by Cohort:\n\nHealthy Volunteers:\n\n\\- No drusen \\>63 um and no subretinal drusenoid deposits in either eye.\n\nEarly AMD:\n\n\\- Study eye with drusen \\>63 um but \\\u003C125 um and no pigmentary changes.\n\nIntermediate AMD:\n\n\\- Study eye with drusen \\>125 um and\u002For pigmentary changes.\n\nExclusion Criteria:\n\n* Claustrophobia relevant to dark-adaptation procedures.\n* Hypersensitivity to indocyanine green or sodium iodide, iodine allergy, or hyperthyroidism.\n* Known pregnancy.\n* Study eye history of ocular surgery other than cataract surgery, YAG capsulotomy, or laser retinopexy.\n* Ocular disease in the study eye that could affect visual function testing in the opinion of the investigators.\n* Medical conditions or planned operations that could interfere with follow-up.\n* Inability to comply with study procedures or insufficient language skills in the study language.\n* Inability to provide informed consent.",true,"ALL","18 Years",{"count":19,"type":20},150,"ESTIMATED","OBSERVATIONAL","This monocentric prospective longitudinal observational study will validate fundus-tracked dark adaptometry as an endpoint for future treatment trials in early and intermediate age-related macular degeneration (AMD). The study will characterize normative cone- and rod-mediated dark adaptation parameters in healthy volunteers, assess test-retest reliability, quantify sensitivity to change over time, evaluate diagnostic and prognostic validity against AMD stage and structural progression, and investigate imaging-, biomarker-, and genetics-based determinants of impaired dark adaptation.",[24],"Age - Related Macular Degeneration (AMD)",[26],"AMD","RECRUITING","2026-03-31",{"date":30,"type":31},"2026-04-07","ACTUAL",{"date":33,"type":31},"2026-02-15",{"date":35,"type":20},"2028-12-15",{"name":37,"class":38},"Maximilian Pfau","OTHER",""]