[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Maze Therapeutics\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":43},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":10,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100579925",false,"NCT06830629","A Phase 2 Study of MZE829 in Adults With APOL1 Kidney Disease","An Open-Label Phase 2 Study to Evaluate the Safety, Tolerability, and Effect on Albuminuria of MZE829 in Adults With Proteinuric Chronic Kidney Disease and the APOL1 High Risk Genotype","Key Inclusion Criteria:\n\n* APOL1 high risk genotype of G1\u002FG1, G2\u002FG2, or G1\u002FG2\n* Chronic kidney disease with persistent albuminuria\n\nKey Exclusion Criteria:\n\n* Organ or bone marrow transplantation\n* History of cancer within past 2 years, excepted for treated non-melanoma skin cancer, stage 0 cervical cancer, or stage 1 prostate cancer\n* Conditions that may alter drug absorption, e.g., history of bariatric surgery\n* Type I diabetes\n* Pregnant or currently nursing\n\nOther inclusion\u002Fexclusion criteria defined in protocol apply.","ALL","18 Years","68 Years",{"count":19,"type":20},56,"ESTIMATED","INTERVENTIONAL",[23],"PHASE2","This is purpose of this study is to evaluate the safety, tolerability, and effect on Albuminuria of MZE829 in Adults with APOL1 Kidney Disease",[26],"Proteinuric Kidney Disease",[28,29],"APOL1-mediated kidney disease (AMKD)","APOL1 kidney disease (AKD)","RECRUITING","2026-04-16",{"date":33,"type":34},"2026-04-17","ACTUAL",{"date":36,"type":34},"2025-02-05",{"date":38,"type":20},"2026-09",{"name":40,"class":41},"Maze Therapeutics","INDUSTRY",81,""]